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Choline metabolism in cancer: implications for diagnosis and therapy
Abstract
Magnetic resonance studies from the last 10 years have conclusively demonstrated that choline metabolism is altered in a wide variety of cancers. In cancer, the choline metabolite profile is characterized by an elevation of phosphocholine and total choline-containing compounds. This elevation is increasingly being used as an endogenous biomarker of cancer. Importantly, the enzymes and pathways resulting in these distinct alterations in phosphocholine and total choline may provide novel molecular targets for specific, targeted anticancer therapies. In this article, we have summarized some of the magnetic resonance spectroscopy and positron emission tomography techniques that are currently available, or will be in the near future, for choline metabolism-based diagnosis, staging and therapy assessment in cancer patients. This review also outlines currently known molecular alterations that cause the aberrant choline metabolite profile in cancers and concludes with a summary of recent research findings that may, in the future, lead to novel anticancer therapies targeting choline metabolism.
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Cited by
Wang, Z., Tang, W. H. W., Buffa, J. A., Fu, X., Britt, E. B., Koeth, R. A., Levison, B. S., Fan, Y., Wu, Y., & Hazen, S. L. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu002 · Cited by 559
Serum metabolomics for early diagnosis of esophageal squamous cell carcinoma by UHPLC-QTOF/MS
Wang, J., Zhang, T., Shen, X., Liu, J., Zhao, D., Sun, Y., Wang, L., Liu, Y., Gong, X., Liu, Y., et al. (2016) · Metabolomics · doi:10.1007/s11306-016-1050-5 · Cited by 373
Backshall, A., Alferez, D., Teichert, F., Wilson, I. D., Wilkinson, R. W., Goodlad, R. A., & Keun, H. C. (2009) · Journal of Proteome Research · doi:10.1021/pr800793w · Cited by 42
Kim, K., Yang, J., Kwack, S. J., Kim, H. S., Ryu, D. H., Kim, Y., Bae, J. Y., Lim, D. S., Choi, S. M., Kwon, M. J., et al. (2013) · Journal of Applied Toxicology · doi:10.1002/jat.2778 · Cited by 25
Metadata
- Authors
- Glunde, K., Jacobs, M. A., & Bhujwalla, Z. M.
- Venue
- Expert Review of Molecular Diagnostics
- Publisher
- Informa UK Limited
- Published
- 2006-11
- Volume
- 6
- Issue
- 6
- Pages
- 821-829
- ISSN
- 1473-7159 (ISSN-L)
- 1744-8352
- OpenAlex
- W2023589957
- Cited by
- 185
- References
- 0
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Glunde, K., Jacobs, M. A., & Bhujwalla, Z. M. (2006). Choline metabolism in cancer: implications for diagnosis and therapy. Expert Review of Molecular Diagnostics. https://doi.org/10.1586/14737159.6.6.821
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