The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Understanding the pathogenesis of abdominal aortic aneurysms
Open accessAbstract
An aortic aneurysm is a dilatation in which the aortic diameter is ≥3.0 cm. If left untreated, the aortic wall continues to weaken and becomes unable to withstand the forces of the luminal blood pressure resulting in progressive dilatation and rupture, a catastrophic event associated with a mortality of 50-80%. Smoking and positive family history are important risk factors for the development of abdominal aortic aneurysms (AAA). Several genetic risk factors have also been identified. On the histological level, visible hallmarks of AAA pathogenesis include inflammation, smooth muscle cell apoptosis, extracellular matrix degradation and oxidative stress. We expect that large genetic, genomic, epigenetic, proteomic and metabolomic studies will be undertaken by international consortia to identify additional risk factors and biomarkers, and to enhance our understanding of the pathobiology of AAA. Collaboration between different research groups will be important in overcoming the challenges to develop pharmacological treatments for AAA.
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Cites
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PLEIOTROPIC EFFECTS OF STATINS
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Cited by
Sakalihasan, N., Michel, J.-B., Katsargyris, A., Kuivaniemi, H., Defraigne, J.-O., Nchimi, A., Powell, J. T., Yoshimura, K., & Hultgren, R. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0030-7 · Cited by 641
Self-citationPetsophonsakul, P., Furmanik, M., Forsythe, R., Dweck, M., Schurink, G. W., Natour, E., Reutelingsperger, C., Jacobs, M., Mees, B., & Schurgers, L. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.312787 · Cited by 341
Wu, Z., Zhang, P., Yue, J., Wang, Q., Zhuang, P., Jehan, S., Fan, L., Xue, J., Zhou, W., & Wang, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02756-2 · Cited by 25
Inhibition of CXCR2 alleviates the development of abdominal aortic aneurysm in Apo E-/- mice
Sun, B., Li, F., Lai, S., Zhang, X., Wang, H., Li, Y., Wang, W., Chen, Y., Liu, B., & Zheng, Y. (2021) · Acta Cirúrgica Brasileira · doi:10.1590/acb360105 · Cited by 8
Metadata
- Authors
- Kuivaniemi, H., Ryer, E. J., Elmore, J. R., & Tromp, G.
- Venue
- Expert Review of Cardiovascular Therapy
- Publisher
- Informa UK Limited
- Published
- 2015-08-25
- Volume
- 13
- Issue
- 9
- Pages
- 975-987
- ISSN
- 1477-9072 (ISSN-L)
- 1744-8344
- OpenAlex
- W1879222445
- Cited by
- 390
- References
- 98
- FWCI
- 12.61
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
