The potential clinical impact of the tissue-based map of the human proteome
Open accessAbstract
Since the first draft of the human genome sequence was published, several attempts have been made to map the human proteome, the functional representation of the genome. One such initiative is the Human Protein Atlas project, which recently released a tissue-based map of the human proteome. The Human Protein Atlas is based on the combination of transcriptomics and antibody-based proteomics for mapping the human proteome down to the single cell level. The comprehensive publicly available database contains more than 13 million unique immunohistochemistry images and provides an excellent resource for exploration and investigation of future drug targets and disease biomarkers.
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More than 15% of the protein‐coding genome encodes for roughly 3,000 secreted proteins, but only a handful of them has been properly annotated.
“Recent studies show that more than 15% of the protein‐coding genome encodes for roughly 3,000 secreted proteins, but only a handful of them has been properly annotated 159, 160, suggesting that a very high number of “molecular messengers” remain to be discovered.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [160]
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References 18 · Cited by 67
- Authors
- Lindskog, C.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Lindskog, Cecilia
- ORCID
- Lindskog, Cecilia
- Venue
- Expert Review of Proteomics
- Publisher
- Informa UK Limited
- Published
- 2015-04-30
- Volume
- 12
- Issue
- 3
- Pages
- 213-215
- ISSN
- 1478-9450 (ISSN-L)
- 1744-8387
- OpenAlex
- W2090672107
- Cited by
- 67
- References
- 18
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 11 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Review of Proteomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Knut och Alice Wallenbergs Stiftelse
- Science for Life Laboratory
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Keywords
- human proteome, Human Protein Atlas, immunohistochemistry, antibody-based proteomics, transcriptomics, single-cell proteomics, therapeutic target, disease biomarkers, proteomics database
- MeSH terms
- Antibodies, Humans, Organ Specificity, Clinical Medicine, Human Genome Project, Proteome, Proteomics, Transcriptome
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