Occurrence, presentation and treatment of candidemia
Abstract
Candida is one of the most common causes of nosocomial bloodstream infections. Candidemia is not confined to hematological patients, intensive care units or abdominal surgery wards, but it is remarkably frequent in the internal medicine setting. High mortality associated with candidemia can be reduced by prompt, appropriate antifungal therapy. The epidemiology of species has been shifting toward non-albicans strains. Significant improvements in nonculture-based diagnostic methods, such as serological markers, have been made in recent years, and novel diagnostic techniques should be further studied to enable early pre-emptive therapy. Treatment guidelines indicate that echinocandins are at present the best choice for patients who are severely ill or possibly infected with fluconazole-resistant strains.
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Advances in medical management such as antineoplasic chemotherapy, organ transplantation, hemodialysis, parenteral nutrition, and central venous catheters contribute to fungal invasion and colonization.
“Advances in medical management as antineoplasic chemotherapy, organ transplantation, hemodialysis, parenteral nutrition, and central venous catheters also contribute to fungal invasion and colonization [11].”
From <i>Candida</i>Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [11]
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References 114 · Cited by 71
- Authors
- Mikulska, M., Del Bono, V., Ratto, S., & Viscoli, C.
- Affiliations
- University of Genoa (IT)
- Ospedale Policlinico San Martino (IT)
- ORCID
- Mikulska, Małgorzata
- Venue
- Expert Review of Clinical Immunology
- Publisher
- Informa UK Limited
- Published
- 2012-11
- Volume
- 8
- Issue
- 8
- Pages
- 755-765
- ISSN
- 1744-666X (ISSN-L)
- 1744-8409
- OpenAlex
- W2146788568
- Cited by
- 71
- References
- 114
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2022: 5 · 2021: 3 · 2019: 2 · 2018: 9 · 2017: 9 · 2016: 14 · 2015: 6 · 2014: 8 · 2013: 5
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Review of Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Keywords
- candidemia, Candida, non-albicans Candida, nosocomial bloodstream infection, internal medicine patients, antifungal therapy, echinocandins, fluconazole resistance, serological diagnosis, mortality
- MeSH terms
- Antifungal Agents, Candida, Humans, Serologic Tests, Fluconazole, Incidence, Prevalence, Drug Resistance, Fungal, Echinocandins, Candidemia
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