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Cited by 311Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Loss of motor function in preclinical Alzheimer's disease

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Buchman, Aron S, Bennett, David A·2011·Expert Review of Neurotherapeutics
DOI 10.1586/ern.11.57PMC PMC3121966
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Abstract

Accumulating evidence suggests that Alzheimer's disease (AD) has a long preclinical phase, during which time its characteristic pathology accumulates and patient function declines, but symptoms are insufficient to warrant a clinical diagnosis of dementia. There have been increasing reports of noncognitive symptoms, including loss of motor function, reported to be associated with incident AD. To understand the link between motor function and preclinical AD, this article examines: our understanding of motor function and its clinical assessment in cohort studies; the relationship of motor function and loss of cognition in older persons; risk factors for cognitive and motor decline; and the relation of post-mortem indices of AD and motor function prior to death. Together, these data suggest that age-related cognitive and motor decline may share a common causation. Furthermore, individuals with a clinical diagnosis of AD may represent the 'tip of the iceberg', since AD pathology may also account for a substantial proportion of cognitive and motor dysfunction currently considered 'normal aging' in older persons without dementia. Thus, AD may have a much larger impact on the health and wellbeing of our aging population.

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  • Neuropsychiatric symptoms, alongside behavioral disorders, deficits in locomotor activity, and changes in reflex and sensory function, precede cognitive deficits in AD.

    “Moreover, neuropsychiatric symptoms, alongside behavioral disorders, deficits in locomotor activity, and changes in reflex and sensory function, precede cognitive deficits in AD (Albers et al., 2015; Buchman and Bennett, 2011; Cortes et al., 2018).”

    From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Buchman and Bennett, 2011

    The Motor performances section (page unavailable) says motor decline in cognitively intact people can precede cognitive impairment by several years. The Odor identification section links impaired smell identification with later MCI and cognitive decline. Our copy does not establish that neuropsychiatric symptoms, behavioral disorders, or reflex changes precede cognitive deficits; its reference to “noncognitive behaviors” does not specify those conditions. (LLM, conf=0.86)

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  1. [1]Bennett DA Part II. Clinical diagnosis and course of Alzheimer’s disease Dis. Mon 2000 46 10 666 687 11078009
  2. [2]Mckhann G Drachman D Folstein M Katzman R Price D Stadlan EM Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease Neurology 1984 34 7 939 944 6610841
  3. [3]Bennett DA Schneider JA Aggarwal NT Decision rules guiding the clinical diagnosis of Alzheimer’s disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study Neuroepidemiology 2006 27 3 169 176 17035694
  4. [4]Arnold SE Part III. Neuropathology of Alzheimer’s disease Dis. Mon 2000 46 10 687 705 11078010
  5. [5]Mirra SS Heyman A McKeel D The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Neurology 1991 41 4 479 479 2011243
  6. [7]Consensus recommendations for the postmortem diagnosis of Alzheimer’s disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease Neurobiol. Aging 1997 18 4 Suppl. S1 S2 9330978
  7. [9]Rentz DM Locascio JJ Becker JA Cognition, reserve, and amyloid deposition in normal aging Ann. Neurol 2010 67 3 353 364 20373347 PMC3074985
  8. [10]Sperling RA Laviolette PS O’Keefe K Amyloid deposition is associated with impaired default network function in older persons without dementia Neuron 2009 63 2 178 188 19640477 PMC2738994
  9. [11]Tomlinson BE Blessed G Roth M Observations on the brains of non-demented old people J. Neurol. Sci 1968 7 2 331 356 5707082
  10. [14]Morris JC Storandt M Mckeel DW Jr Cerebral amyloid deposition and diffuse plaques in ‘normal’ aging: evidence for presymptomatic and very mild Alzheimer’s disease Neurology 1996 46 3 707 719 8618671
  11. [17]Buchman AS Wilson RS Boyle PA Bienias JL Bennett DA Grip strength and the risk of incident Alzheimer’s disease Neuroepidemiology 2007 29 1–2 66 73 17925596
  12. [18]Wilson RS Arnold SE Schneider JA Boyle PA Buchman AS Bennett DA Olfactory impairment in presymptomatic Alzheimer’s disease Ann. NY Acad. Sci 2009 1170 730 735 19686220 PMC2857767
  13. [19]Wilson RS Barnes LL Mendes de Leon CF Depressive symptoms, cognitive decline, and risk of AD in older persons Neurology 2002 59 3 364 370 12177369
  14. [20]Buchman AS Wilson RS Bienias JL Shah RC Evans DA Bennett DA Change in body mass index and risk of incident Alzheimer disease Neurology 2005 65 6 892 897 16186530
  15. [21]Hikosaka O Nakamura K Sakai K Nakahara H Central mechanisms of motor skill learning Curr. Opin. Neurobiol 2002 12 2 217 222 12015240
  16. [22]Burke RE Some unresolved issues in motor unit research Adv. Exp. Med. Biol 2002 508 171 178 12171107
  17. [24]Jeannerod M Arbib MA Rizzolatti G Sakata H Grasping objects: the cortical mechanisms of visuomotor transformation Trends Neurosci 1995 18 314 320 7571012
  18. [25]Fogassi L Luppino G Motor functions of the parietal lobe Curr. Opin. Neurobiology 2005 15 6 626 631 16271458
  19. [27]Rizzolatti G Luppino G The cortical motor system Neuron 2001 31 6 889 901 11580891
  20. [28]Halsband U Lange RK Motor learning in man: a review of functional and clinical studies J. Physiol. Paris 2006 99 4–6 414 424 16730432
  21. [29]Lehericy S Bardinet E Tremblay L Motor control in basal ganglia circuits using fMRI and brain atlas approaches Cereb. Cortex 2006 16 2 149 161 15858164
  22. [30]Poppele R Bosco G Sophisticated spinal contributions to motor control Trends Neurosci 2003 26 269 276 12744844
  23. [31]Bizzi E D’Avella A Saltiel P Tresch M Modular organization of spinal motor systems Neuroscientist 2002 8 5 437 442 12374428
  24. [33]Lanuza GM Gosgnach S Pierani A Jessell TM Goulding M Genetic identification of spinal interneurons that coordinate left–right locomotor activity necessary for walking movements Neuron 2004 42 3 375 373 15134635
  25. [34]Gordon IT Whelan PJ Deciphering the organization and modulation of spinal locomotor central pattern generators J. Exp. Biol 2006 209 11 2007 2014 16709903
  26. [37]Zaehle T Jordan K Wüstenberg T Baudewig J Dechent P Mast FW The neural basis of the egocentric and allocentric spatial frame of reference Brain Res 2007 1137 92 103 17258693
  27. [38]Bakker M De Lange FP Helmich RC Scheeringa R Bloem BR Toni I Cerebral correlates of motor imagery of normal and precision gait Neuroimage 2008 41 3 998 1010 18455930
  28. [39]Rosano C Aizenstein HJ Studenski S Newman AB A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults J. Gerontol. A Biol. Sci. Med. Sci 2007 62 9 1048 1055 17895446
  29. [40]Rosano C Brach J Longstreth WT Jr Newman AB Quantitative measures of gait characteristics indicate prevalence of underlying subclinical structural brain abnormalities in high-functioning older adults Neuroepidemiology 2006 26 1 52 60 16254454
  30. [41]Rosano C Brach J Studenski S Longstreth WT Jr Newman AB Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults Neuroepidemiology 2007 29 3–4 193 200 18043004 PMC2824582
  31. [42]Buchman AS Wilson RS Bienias JL Bennett DA Change in frailty and risk of death in older persons Exp. Aging Res 2009 35 1 61 82 19173102 PMC2729435
  32. [43]Delmonico MJ Harris TB Lee J-S Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women J. Am. Geriatr. Soc 2007 55 5 769 774 17493199
  33. [44]Louis ED Schupf N Marder K Tang MX Functional correlates of mild parkinsonian signs in the community-dwelling elderly: poor balance and inability to ambulate independently Mov. Disord 2006 21 3 411 416 16211605
  34. [46]Louis ED Tang MX Schupf N Mayeux R Functional correlates and prevalence of mild parkinsonian signs in a community population of older people Arch. Neurol 2005 62 2 297 302 15710859
  35. [47]Fried LP Ferrucci L Darer J Williamson JD Anderson G Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care J. Gerontol. A Biol. Sci. Med. Sci 2004 59 3 255 263 15031310
  36. [48]Louis ED Bennett DA Mild parkinsonian signs: an overview of an emerging concept Mov. Disord 2007 22 12 1681 1688 17534951
  37. [49]Baumgartner RN Koehler KM Gallagher D Epidemiology of sarcopenia among the elderly in New Mexico Am. J. Epidemiol 1998 147 8 755 763 9554417
  38. [51]Louis ED Schupf N Manly J Marder K Tang MX Mayeux R Association between mild parkinsonian signs and mild cognitive impairment in a community Neurology 2005 64 7 1157 1161 15824340
  39. [52]Buchman AS Wilson RS Boyle PA Bienias JL Bennett DA Change in motor function and risk of mortality in older persons J. Am. Geriatr. Soc 2007 55 1 11 19 17233680
  40. [53]Buchman AS Leurgans SE Boyle PA Schneider JA Arnold SE Bennett DA Combinations of motor measures more strongly predict adverse health outcomes in old age: the Rush Memory and Aging Project, a community-based cohort study BMC Med 2011 (In press) PMC3100235 21507235
  41. [54]Chainay H Louarn C Humphreys GW Ideational action impairments in Alzheimer’s disease Brain Cogn 2006 62 3 198 205 16777309
  42. [55]Derouesné C Lagha-Pierucci S Thibault S Baudouin-Madec V Lacomblez L Apraxic disturbances in patients with mild to moderate Alzheimer’s disease Neuropsychologia 2000 38 13 1760 1769 11099734
  43. [56]Della Sala S Spinnler H Venneri A Walking difficulties in patients with Alzheimer’s disease might originate from gait apraxia J. Neurol. Neurosurg. Psychiatry 2004 75 2 196 201 14742586 PMC1738895
  44. [57]Hebert LE Bienias JL Mccann JJ Scherr PA Wilson RS Evans DA Upper and lower extremity motor performance and functional impairment in Alzheimer’s disease Am. J. Alzheimers Dis. Other Demen 2010 25 5 425 431 20484749 PMC3033748
  45. [58]Agosta F Rocca MA Pagani E Sensorimotor network rewiring in mild cognitive impairment and Alzheimer’s disease Hum. Brain Mapp 2010 31 4 515 525 19777557 PMC6871105
  46. [59]Babiloni C Frisoni GB Vecchio F Stability of clinical condition in mild cognitive impairment is related to cortical sources of α rhythms: an electroencephalographic study Hum. Brain Mapp 2010 (Epub ahead of print) PMC6869969 21181798
  47. [60]Jahng G-H Xu S Weiner M Meyerhoff D Park S Schuff N DTI studies in patients with Alzheimer’s disease, mild cognitive impairment, or normal cognition with evaluation of the intrinsic background gradients Neuroradiology 2011 1-14-14 PMC3184226 21340578
  48. [61]Stump CS Henriksen EJ Wei Y Sowers JR The metabolic syndrome: role of skeletal muscle metabolism Ann. Med 2006 38 6 389 402 17008303
  49. [62]Atti AR Palmer K Volpato S Winblad B De Ronchi D Fratiglioni L Late-life body mass index and dementia incidence: nine-year follow-up data from the Kungsholmen Project J. Am. Geriatr. Soc 2008 56 1 111 116 18028342
  50. [63]Dahl A Hassing LB Fransson E Being overweight in midlife is associated with lower cognitive ability and steeper cognitive decline in late life J. Gerontol. A Biol. Sci. Med. Sci 2010 65A 1 57 62 19349594 PMC2796876
  51. [64]Ogunniyi A Gao S Unverzagt FW Weight loss and incident dementia in elderly Yoruba Nigerians: a 10-year follow-up study Int. Psychogeriatr 2010 23 3 387 394 20735893 PMC3044788
  52. [65]Whitmer RA Gustafson DR Barrett-Connor E Haan MN Gunderson EP Yaffe K Central obesity and increased risk of dementia more than three decades later Neurology 2008 71 14 1057 1064 18367704
  53. [66]Stewart R Masaki K Xue Q-L A 32-year prospective study of change in body weight and incident dementia: the Honolulu–Asia Aging study Arch. Neurol 2005 62 1 55 60 15642850
  54. [67]Gustafson D Rothenberg E Blennow K Steen B Skoog I An 18-year follow-up of overweight and risk of Alzheimer disease Arch. Intern. Med 2003 163 13 1524 1528 12860573
  55. [68]Verdijk LB Snijders T Beelen M Characteristics of muscle fiber type are predictive of skeletal muscle mass and strength in elderly men J. Am. Geriatr. Soc 2010 58 11 2069 2075 21054286
  56. [70]Hairi NN Cumming RG Naganathan V Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the concord Health and Ageing in Men Project J. Am. Geriatr. Soc 2010 58 11 2055 2062 21054284
  57. [71]Gustafson D Adiposity indices and dementia Lancet Neurol 2006 5 8 713 720 16857578. • Suggests that that the link between BMI and risk of dementia is more complex and may vary over the lifespan.
  58. [72]Boyle PA Buchman AS Wilson RS Leurgans SE Bennett DA Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons Arch. Neurol 2009 66 11 1339 1344 19901164 PMC2838435. • Loss of strength is common in old age and this study demonstrated that appendicular and axial muscle strength in older persons is associated with the risk of developing mild cognitive impairment (MCI), Alzheimer’s disease (AD) and cognitive decline.
  59. [73]Vandervoort AA Aging of the human neuromuscular system Muscle Nerve 2002 25 1 17 25 11754180
  60. [74]Camicioli R Howieson D Oken B Sexton G Kaye J Motor slowing precedes cognitive impairment in the oldest old Neurology 1998 50 5 1496 1498 9596020
  61. [75]Buracchio T Dodge HH Howieson D Wasserman D Kaye J The trajectory of gait speed preceding mild cognitive impairment Arch. Neurol 2010 67 8 980 989 20697049 PMC2921227. •• Motor decline, as indexed by gait speed, accelerates up to 12 years before MCI. Thus, the rate of change in motor decline may identify individuals at risk for developing dementia during its preclinical stage.
  62. [76]Boyle PA Wilson RS Buchman AS Lower extremity motor function and disability in mild cognitive impairment Exp. Aging Res 2007 33 3 355 371 17497375
  63. [77]Aggarwal NT Wilson RS Beck TL Bienias JL Bennett DA Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease Arch. Neurol 2006 63 12 1763 1769 17172617
  64. [78]Watson NL Rosano C Boudreau RM Executive function, memory, and gait Speed decline in well-functioning older adults J. Gerontol. A Biol. Sci. Med. Sci 2010 65A 10 1093 1100 20581339 PMC2949334
  65. [81]Waite LM Grayson DA Piguet O Creasey H Bennett HP Broe GA Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study J. Neurol. Sci 2005 229 230 89 93 15760625
  66. [82]Ble A Volpato S Zuliani G Executive function correlates with walking speed in older persons: the InCHIANTI study J. Am. Geriatr. Soc 2005 53 3 410 415 15743282
  67. [83]Soumare A Tavernier B Alperovitch A Tzourio C Elbaz A A cross-sectional and longitudinal study of the relationship between walking speed and cognitive function in community-dwelling elderly people J. Gerontol. A Biol. Sci. Med. Sci 2009 1058 1065 19561146
  68. [84]Wilson RS Schneider JA Bienias JL Evans DA Bennett DA Parkinsonianlike signs and risk of incident Alzheimer disease in older persons Arch. Neurol 2003 60 4 539 544 12707067
  69. [85]Richards M Stern Y Mayeux R Subtle extrapyramidal signs can predict the development of dementia in elderly individuals Neurology 1993 43 11 2184 2188 8232926
  70. [86]Portet F Scarmeas N Cosentino S Helzner EP Stern Y Extrapyramidal signs before and after diagnosis of incident Alzheimer disease in a prospective population study Arch. Neurol 2009 66 9 1120 1126 19752301 PMC2896248
  71. [88]Bandeen-Roche K Xue Q-L Ferrucci L Phenotype of frailty: characterization in the women’s health and aging studies J. Gerontol. A Biol. Sci. Med. Sci 2006 61 3 262 266 16567375
  72. [89]Buchman AS Boyle PA Wilson RS Tang Y Bennett DA Frailty is associated with incident Alzheimer’s disease and cognitive decline in the elderly Psychosom. Med 2007 69 5 483 489 17556640
  73. [90]Boyle PA Buchman AS Wilson RS Leurgans SE Bennett DA Physical frailty is associated with incident mild cognitive impairment in community-based older persons J. Am. Geriatr. Soc 2010 58 2 248 255 20070417 PMC3150526
  74. [91]Ungvari Z Kaley G De Cabo R Sonntag WE Csiszar A Mechanisms of vascular aging: new perspectives J. Gerontol. A Biol. Sci. Med. Sci 2010 65A 10 1028 1041 20576649 PMC2950814
  75. [92]Dilger RN Johnson RW Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system J. Leukoc. Biol 2008 84 4 932 939 18495785 PMC2538600
  76. [93]Kapogiannis D Mattson MP Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer’s disease Lancet Neurol 2011 10 2 187 198 21147038 PMC3026092
  77. [94]Sultana R Perluigi M Butterfield D Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Aβ in pathogenesis Acta Neuropathologica 2009 118 1 131 150 19288120 PMC2818870
  78. [95]Bennett DA Schneider JA Wilson RS Bienias JL Arnold SE Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function Arch. Neurol 2004 61 3 378 384 15023815
  79. [96]Bennett DA Schneider JA Wilson RS Bienias JL Berry-Kravis E Arnold SE Amyloid mediates the association of apolipoprotein E ε4 allele to cognitive function in older people J. Neurol. Neurosurg. Psychiatry 2005 76 9 1194 1199 16107349 PMC1739810
  80. [97]Mahley RW Weisgraber KH Huang Y Inaugural article: apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer’s disease Proc. Natl Acad. Sci 2006 103 15 5644 5651 16567625 PMC1414631
  81. [98]Houlden H Greenwood R Apolipoprotein E4 and traumatic brain injury J. Neurol. Neurosurg. Psychiatry 2006 77 10 1106 1107 16793859 PMC2077546
  82. [99]Wilson RS Schneider JA Barnes LL The apolipoprotein E ε4 allele and decline in different cognitive systems during a 6-year period Arch. Neurol 2002 59 7 1154 1160 12117364
  83. [100]Sudlow C Martinez Gonzalez NA Kim J Clark C Does Apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage?: systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls Stroke 2006 37 2 364 370 16385096 PMC2577180
  84. [101]Burt TD Agan BK Marconi VC Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression Proc. Natl Acad. Sci 2008 105 25 8718 8723 18562290 PMC2438419
  85. [102]Buchman AS Boyle PA Wilson RS Beck T Kelly JF Bennett DA Apolipoprotein E ε4 allele is associated with more rapid motor decline in older persons Alzheimer Dis. Assoc. Disord 2009 23 63 69 19266700 PMC2662708
  86. [103]Jun G Naj AC Beecham GW Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes Arch. Neurol 2010 67 12 1473 1484 20697030 PMC3048805
  87. [104]Seshadri S Fitzpatrick AL Ikram MA Genome-wide analysis of genetic loci associated with Alzheimer disease JAMA 2010 303 18 1832 1840 20460622 PMC2989531
  88. [105]Claeys KG Maisonobe T Böhm J Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation Neurology 2010 74 6 519 521 20142620
  89. [106]Wilson RS Arnold SE Tang Y Bennett DA Odor identification and decline in different cognitive domains in old age Neuroepidemiology 2006 26 2 61 67 16352908
  90. [107]Wilson RS Schneider JA Arnold SE Tang Y Boyle PA Bennett DA Olfactory identification and incidence of mild cognitive impairment in older age Arch. Gen. Psychiatry 2007 64 7 802 808 17606814
  91. [108]Wilson RS Yu L Schneider JA Arnold SE Buchman AS Bennett DA Lewy bodies and olfactory dysfunction in old age Chem. Senses 2011 (Epub ahead of print) PMC3073534 21257733
  92. [109]Wilson RS Arnold SE Buchman AS Tang Y Bennett DA Odor identification and progression of parkinsonian signs in older persons Exp. Aging Res 2008 34 3 173 187 18568978 PMC3142656
  93. [110]Schubert CR Carmichael LL Murphy C Klein BE Klein R Cruickshanks KJ Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults J. Am. Geriatr. Soc 2008 56 8 1517 1521 18662205 PMC2587240
  94. [111]Olofsson JK Ronnlund M Nordin S Nyberg L Nilsson LG Larsson M Odor identification deficit as a predictor of five-year global cognitive change: interactive effects with age and ApoE-ε4 Behav. Genet 2009 39 5 496 503 19633944
  95. [113]Rocca WA Petersen RC Knopman DS Trends in the incidence and prevalence of Alzheimer’s disease, dementia, and cognitive impairment in the United States Alzheimers Demen 2011 7 1 80 93 PMC3026476 21255746
  96. [114]Hoffman LB Schmeidler J Lesser GT Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons Neurology 2009 72 20 1720 1726 19228583 PMC2683736
  97. [115]Beeri MS Ravona-Springer R Silverman JM Haroutunian V The effects of cardiovascular risk factors on cognitive compromise Dialogues Clin. Neurosci 2009 11 2 201 212 19585955 PMC3093131
  98. [116]Arvanitakis Z Bennett DA Wilson RS Barnes LL Diabetes and cognitive systems in older black and white persons Alzheimer Dis. Assoc. Disord 2009 24 1 37 42 19568148 PMC2837103
  99. [117]Arvanitakis Z Wilson RS Bienias JL Evans DA Bennett DA Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function Arch. Neurol 2004 61 5 661 666 15148141
  100. [118]Arvanitakis Z Wilson RS Li Y Aggarwal NT Bennett DA Diabetes and function in different cognitive systems in older individuals without dementia Diabetes Care 2006 29 3 560 565 16505506
  101. [120]Sorond FA Galica A Serrador JM Cerebrovascular hemodynamics, gait, and falls in an elderly population Neurology 2010 74 20 1627 1633 20479362 PMC2875129
  102. [121]Arvanitakis Z Wilson RS Bienias JL Bennett DA Diabetes and parkinsonian signs in older persons Alzheimer Dis. Assoc. Disord 2007 21 2 144 149 17545740
  103. [122]Arvanitakis Z Wilson RS Schneider JA Bienias JL Evans DA Bennett DA Diabetes mellitus and progression of rigidity and gait disturbance in older persons Neurology 2004 63 6 996 1001 15452289
  104. [123]Buchman AS Boyle PA Wilson RS Leurgans S Shah RC Bennett DA Respiratory muscle strength predicts decline in mobility in older persons Neuroepidemiology 2008 31 3 174 180 18784416 PMC2741394
  105. [124]Buchman AS Boyle PA Leurgans SE Evans DA Bennett DA Pulmonary function, muscle strength and mobility disability in community-dwelling elders Proc. Am. Thorac. Soc 2009 6 581 587 19934353 PMC3132218
  106. [125]Warburton DE Nicol CW Bredin SS Health benefits of physical activity: the evidence CMAJ 2006 174 6 801 809 16534088 PMC1402378
  107. [126]Larson EB Physical activity for older adults at risk for Alzheimer disease JAMA 2008 300 9 1077 1079 18768421
  108. [127]Barak Y Aizenberg D Is dementia preventable? Focus on Alzheimer’s disease Expert Rev. Neurother 2010 10 11 1689 1698 20977327
  109. [128]Scarmeas N Luchsinger JA Schupf N Physical activity, diet, and risk of Alzheimer disease JAMA 2009 302 6 627 637 19671904 PMC2765045
  110. [129]Lautenschlager NT Cox KL Flicker L Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial JAMA 2008 300 9 1027 1037 18768414
  111. [130]Liu-Ambrose T Nagamatsu LS Graf P Beattie BL Ashe MC Handy TC Resistance training and executive functions: a 12-month randomized controlled trial Arch. Intern. Med 2010 170 2 170 178 20101012 PMC3448565
  112. [132]Etgen T Sander D Huntgeburth U Poppert H Forstl H Bickel H Physical activity and incident cognitive impairment in elderly persons: the INVADE Study Arch. Int. Med 2010 170 2 186 193 20101014
  113. [133]Evans DA Bienias JL Alcohol consumption and cognition N. Engl. J. Med 2005 352 3 289 290 15659731
  114. [134]Buchman AS Boyle PA Wilson RS Bienias JL Bennett DA Physical activity and motor decline in older persons Muscle Nerve 2007 35 354 362 17143881
  115. [135]Buchman AS Boyle PA Wilson RS Fleischman DA Leurgans S Bennett DA Association between late-life social activity and motor decline in older adults Arch. Int. Med 2009 169 12 1139 1146 19546415 PMC2775502. • Psychosocial factors are known to be related to the rate of cognitive decline. This study found that higher levels of social engagement in older individuals were associated with a slower rate of motor decline. Thus, motor and cognitive decline may share similar risk factors.
  116. [136]Fratiglioni L Paillard-Borg S Winblad B An active and socially integrated lifestyle in late life might protect against dementia Lancet Neurol 2004 3 6 343 353 15157849
  117. [137]Wilson RS Arnold SE Schneider JA Li Y Bennett DA Chronic distress, age-related neuropathology, and late-life dementia Psychosom. Med 2007 69 1 47 53 17244848
  118. [138]Wilson RS Evans DA Bienias JL Mendes de Leon CF Schneider JA Bennett DA Proneness to psychological distress and risk of Alzheimer’s disease Neurology 2003 61 11 1479 1485 14663028
  119. [139]Wilson RS Krueger KR Arnold SE Loneliness and risk of Alzheimer disease Arch. Gen. Psychiatry 2007 64 2 234 240 17283291
  120. [140]Wilson RS Schneider JA Boyle PA Arnold SE Tang Y Bennett DA Chronic distress and incidence of mild cognitive impairment Neurology 2007 68 24 2085 2092 17562829
  121. [141]Buchman A Boyle P Wilson R Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study BMC Geriatrics 2010 10 1 77 20969786 PMC2975650
  122. [142]Rhodes RE Smith NEI Personality correlates of physical activity: a review and meta-analysis Br. J. Sports Med 2006 40 12 958 965 17124108 PMC2577457
  123. [143]Tolea MI Costa PT Terracciano A Sex-specific correlates of walking speed in a wide age-ranged population J. Gerontol. B Psycholog. Sci. Soc. Sci 2010 65B 2 174 184 PMC2821942 20051464
  124. [144]Buchman AS Boyle PA Leurgans SE Barnes LL Bennett DA Cognitive function is associated with the development of mobility impairments in community-dwelling elders Am. J. Geriatr. Psych 2011 (Epub ahead of print) PMC3101472 21606900
  125. [145]Schneider JA Arvanitakis Z Leurgans SE Bennett DA The neuropathology of probable Alzheimer disease and mild cognitive impairment Ann. Neurol 2009 66 2 200 208 19743450 PMC2812870
  126. [147]Greenberg SA How citation distortions create unfounded authority: analysis of a citation network BMJ 2009 339 b2680 19622839 PMC2714656
  127. [148]Salajegheh M Pinkus JL Nazareno R Amato AA Parker KC Greenberg SA Nature of ‘Tau’ immunoreactivity in normal myonuclei and inclusion body myositis Muscle Nerve 2009 40 4 520 528 19626672
  128. [150]Buchman AS Schneider JA Wilson RS Bienias JL Bennett DA Body mass index in older persons is associated with Alzheimer disease pathology Neurology 2006 67 1949 1954 17159099
  129. [151]Buchman AS Schneider JA Leurgans S Bennett DA Physical frailty in older persons is associated with Alzheimer disease pathology Neurology 2008 71 7 499 504 18695161 PMC2676981
  130. [152]Schneider JA Li JL Li Y Wilson RS Kordower JH Bennett DA Substantia nigra tangles are related to gait impairment in older persons Ann. Neurol 2006 59 1 166 173 16374822
  131. [153]Gearing M Levey AI Mirra SS Diffuse plaques in the striatum in Alzheimer disease (AD): relationship to the striatal mosaic and selected neuropeptide markers J. Neuropathol. Exp. Neurol 1997 56 12 1363 1370 9413285
  132. [154]Wolf DS Gearing M Snowdon DA Mori H Markesbery WR Mirra SS Progression of regional neuropathology in Alzheimer disease and normal elderly: findings from the Nun study Alzheimer Dis. Assoc. Disord 1999 13 4 226 231 10609672
  133. [155]Horoupian DS Wasserstein PH Alzheimer’s disease pathology in motor cortex in dementia with Lewy bodies clinically mimicking corticobasal degeneration Acta Neuropathol. (Berl.) 1999 98 3 317 322 10483792
  134. [156]Burns JM Galvin JE Roe CM Morris JC McKeel DW The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs Neurology 2005 64 8 1397 1403 15851730
  135. [157]Suva D Favre I Kraftsik R Esteban M Lobrinus A Miklossy J Primary motor cortex involvement in Alzheimer disease J. Neuropathol. Exp. Neurol 1999 58 11 1125 1134 10560655
  136. [159]Boyle PA Wilson RS Schneider JA Bienias JL Bennett DA Processing resources reduce the effect of Alzheimer pathology on other cognitive systems Neurology 2008 70 17 1534 1542 18354077 PMC10382255
  137. [160]Rose G The Strategy of Preventive Medicine 1992 Oxford, UK Oxford University Press
  138. [161]Nithianantharajah J Hannan AJ The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disorders Prog. Neurobiol 2009 89 4 369 382 19819293

Authors
Buchman, A. S., & Bennett, D. A.
Affiliations
Rush University Medical Center (US)
Corresponding author
Buchman, Aron S
ORCID
Venue
Expert Review of Neurotherapeutics
Publisher
Informa UK Limited
Published
2011-05
Volume
11
Issue
5
Pages
665-676
ISSN
  • 1473-7175 (ISSN-L)
  • 1744-8360
DOI
10.1586/ern.11.57
PMC
PMC3121966
OpenAlex
W2150122398
Cited by
311
References
169
Citations by year
2026: 24 · 2025: 28 · 2024: 43 · 2023: 26 · 2022: 39 · 2021: 30 · 2020: 27 · 2019: 20 · 2018: 29 · 2017: 16 · 2016: 11 · 2015: 6 · 2014: 7 · 2013: 2 · 2012: 3
FWCI
0.50
Type
journal article
Language
en
Open access
Locations
  • Expert Review of Neurotherapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG017917, P30-AG 10161, P01 AG09466, R01-AG-24480, R01‐AG17917, R01 AG15819, R01AG30142, R01AG030142, K23 AG 23040, R01AG015819, P30AG010161, K23AG023040, R01AG024480, P01AG009466)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
preclinical Alzheimer's disease, motor function decline, non-cognitive symptoms, cognitive decline, age-related decline, normal aging, older adults, risk factors
MeSH terms
Aging, Alzheimer Disease, Cognition, Dementia, Humans, Motor Activity, Neuropsychological Tests, Time Factors, Cohort Studies

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