CoChat
Sign Up
Cited by 44Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesBipolar Disorder and Treatment

Brain functional domains inform therapeutic interventions in attention-deficit/hyperactivity disorder and pediatric bipolar disorder

Open access
Passarotti, Alessandra M, Pavuluri, Mani N·2011·Expert Review of Neurotherapeutics
DOI 10.1586/ern.11.71PMC PMC3129632
Open this paper in CoChat — free account

Abstract

A deeper understanding of how the relationships between impulsivity, reward systems and executive function deficits may be similar or different in attention-deficit/hyperactivity disorder (ADHD) and pediatric bipolar disorder (PBD) is fundamental for better defining phenotypy in these two developmental illnesses, and moving towards improved treatment and intervention. We focus our article on recent neurocognitive and neuroimaging data examining the behavioral and neural aspects of poor behavior regulation, response inhibition and reward systems in ADHD and PBD. In light of recent research evidence, we propose that the common behavioral manifestations of impulsivity in ADHD and PBD may indeed originate from different neural mechanisms mediated by altered reward systems. In order to define and differentiate these mechanisms, unlike previous approaches, our theoretical model examines the interface of the dorsal frontostriatal circuit, involved in behavior regulation, and the ventral frontostriatal circuit, which is involved in reward-related and affect processes. Preliminary evidence suggests that the neural systems involved in impulsivity, reward systems and executive function engage differently in the two illnesses. In PBD, 'emotional impulsivity' is predominantly 'bottom-up' and emotionally/motivationally driven, and stems from ventral frontostriatal circuitry dysfunction. By contrast, in ADHD 'cognitive impulsivity' is predominantly 'top-down' and more 'cognitively driven', and stems from dorsal frontostriatal dysfunction. We discuss this evidence in view of clinically relevant questions and implications for illness-based intervention. We conclude that the reward-related mechanisms underlying the interactions between executive function, behavior regulation and impulsivity in PBD and ADHD may be differentially compromised, and in accordance differently shape the clinical symptoms of impulsivity and goal-directed behavior.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1586/ern.11.71

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • IFC underactivation during cognitive and motivation control tasks was disorder-specific to ADHD relative to borderline personality and bipolar disorder.

    “IFC underactivation during cognitive and motivation control tasks was also found to be disorder-specific to ADHD relative to borderline personality (Sebastian et al., 2014) and bipolar disorder (Passarotti and Pavuluri, 2011).”

    From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Passarotti and Pavuluri, 2011

    The section on inhibitory functions reports that adolescents with ADHD failed to engage the VLPFC relative to adolescents with pediatric bipolar disorder during a response-inhibition task, supporting the cognitive-control comparison. The reward-sensitivity section does not establish IFC underactivation during motivational-control tasks relative to bipolar disorder. This citation is attached to the bipolar comparison, not the separate borderline-personality comparison. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Affective childhood disorders appear to suffer from similar underactivations in ventromedial and/or dorsomedial prefrontal and limbic regions during cognitive control.

    “These more “affective childhood disorders” appear to suffer from similar underactivations in ventromedial and/or dorsomedial prefrontal and limbic regions during cognitive control (Passarotti and Pavuluri, 2011; Sebastian et al., 2014; Alegria et al., 2016; Norman et al., 2016;”

    From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Passarotti and Pavuluri, 2011

    In “Inhibitory functions: common external phenotype & differential neural operations,” the paper reports prefrontal dysfunction during response inhibition in pediatric bipolar disorder and ADHD, but describes different affected regions across the two disorders rather than similar underactivation. In “Cognitive versus emotional impulsivity,” it associates pediatric bipolar disorder with reduced prefrontal regulatory function but hypothesizes amygdala and ventral-striatal overactivity, not limbic underactivation. The copy provides no page numbers for these passages. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The citation lists haven’t been fetched yet

References 192 · Cited by 44

Research works printed but not linked: 140

  1. [1]Insel TR Cuthbert BN Endophenotypes: bridging genomic complexity and disorder heterogeneity Biol. Psychiatry 2009 66 11 988 989 19900610
  2. [2]Galanter CA Leibenluft E Frontiers between attention deficit hyperactivity disorder and bipolar disorder Child Adolesc. Psychiatr. Clin. N. Am 2008 17 325 346 18295149 •• Influential paper that examines and compares the two developmental disorders based on their symptoms, and addresses the issue of irritability and severe mood dysregulation.
  3. [3]Singh MK Chang KD Mazaika P Neural correlates of response inhibition in pediatric bipolar disorder J. Child Adolesc. Psychopharmacol 2010 20 1 15 24 20166792 PMC2835388
  4. [4]Geller B Warner K Williams M Zimerman B Prepubertal and young adolescent bipolarity versus ADHD: assessment and validity using the WASH-U-KSADS, CBCL, and TRF J. Affect. Disord 1998 51 2 93 100 10743842
  5. [5]Biederman J Mick E Faraone SV Spencer T Wilens TE Wozniak J Pediatric mania: a developmental subtype of bipolar disorder? Biol. Psychiatry 2000 48 458 466 11018219
  6. [6]Dickstein DP Garvey M Pradella AG Neurologic examination abnormalities in children with bipolar disorder or attention deficit/hyperactivity disorder Biol. Psychiatry 2005 58 517 524 16239160
  7. [7]Biederman J Faraone SV Attention-deficit hyperactivity disorder Lancet 2005 366 237 248 16023516
  8. [9]Barkley RA Psychosocial treatments for attention-deficit/hyperactivity disorder in children J. Clin. Psychiatry 2002 63 Suppl. 12 36 43 12562060
  9. [10]Barkley RA Fischer M The unique contribution of emotional impulsiveness to impairment in major life activities in hyperactive children as adults J. Am. Acad. Child Adolesc. Psychiatry 2010 49 5 503 513 20431470
  10. [13]Scheres A Milham MP Knutson B Castellanos FX Ventral striatal hyper-responsiveness during reward anticipation in attention deficit/hyperactivity disorder Biol. Psychiatry 2007 61 5 720 724 16950228
  11. [14]Rubia K Taylor E Smith H Oksannen H Overmeyer S Newman S Neuropsychological analyses of impulsiveness in childhood hyperactivity Br. J. Psychiatry 2001 179 138 143 11483475
  12. [15]Bush G Frazier JA Rauch SL Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop Biol. Psychiatry 1999 45 1542 1552 10376114
  13. [17]Pavuluri MN Birmaher B Naylor M Pediatric bipolar disorder: ten year review J. Am. Acad. Child Adolesc. Psychiatry 2005 44 9 846 871 16113615
  14. [18]Leibenluft E Charney DS Towbin KE Bhangoo RK Pine DS Defining clinical phenotypes of juvenile mania Am. J. Psychiatry 2003 160 430 437 12611821
  15. [19]Geller B Zimerman B Williams M DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls J. Child Adolesc. Psychopharmacol 2002 12 1 11 25 12014591
  16. [20]Rich BA Schmajuk M Perez-Edgar KE Pine DS Fox NA Leibenluft E The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder Biol. Psychiatry 2005 58 532 539 15953589
  17. [21]Dickstein DP Nelson EE McClure EB Cognitive flexibility in phenotypes of pediatric bipolar disorder J. Am. Acad. Child Adolesc. Psychiatry 2007 46 3 341 355 17314720
  18. [22]Biederman J Faraone S Mick E Attention-deficit hyperactivity disorder and juvenile mania: an overlooked comorbidity? J. Am. Acad. Child Adolesc. Psychiatry 1996 35 8 997 1008 8755796
  19. [23]Pavuluri MN Schenkel LS Aryal S Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients Am. J. Psychiatry 2006 163 286 293 16449483
  20. [24]Pavuluri MN West A Hill K Jindal K Sweeney JA Neurocognitive function in pediatric bipolar disorder: three-year follow-up shows cognitive development lagging behind healthy youth J. Am. Acad. Child Adolesc. Psychiatry 2009 48 3 299 307 19182689 PMC2773500 •• First study on a 3-year follow-up on cognitive deficits in pediatric bipolar disorder (PBD). This study showed persistence of deficits over time, and even with optimal treatment outcome in PBD.
  21. [25]Lewinsohn PM Shankman SA Gau JM Klein DN The prevalence and co-morbidity of subthreshold psychiatric conditions Psychol. Med 2004 34 4 613 622 15099416
  22. [26]DelBello MP Hanseman D Adler CM Fleck DE Strakowski SM Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode Am. J. Psychiatry 2007 164 4 582 590 17403971
  23. [27]Birmaher B Longitudinal course of pediatric bipolar disorder Am. J. Psychiatry 2007 164 4 537 539 17403961
  24. [28]Miller EK Cohen JD An integrative theory of prefrontal cortex function Annu. Rev. Neurosci 2001 24 167 202 11283309
  25. [29]Giedd JN Blumenthal J Jeffries NO Brain development during childhood and adolescence: a longitudinal MRI study Nat. Neurosci 1999 2 10 861 863 10491603
  26. [31]Luna B Thulborn KR Munoz DP Maturation of widely distributed brain function subserves cognitive development NeuroImage 2001 13 786 793 11304075
  27. [32]Luna B Garver KE Urban TN Lazar N Sweeney JA Maturation of cognitive processes from late childhood to adulthood Child Dev 2004 75 1357 1372 15369519
  28. [33]Posner MI Rothbart MK Developing mechanisms of self-regulation Dev. Psychopathol 2000 12 427 441 11014746
  29. [36]Rich BA Holroyd T Carver FW A preliminary study of the neural mechanisms of frustration in pediatric bipolar disorder using magnetoencephalography Depress. Anxiety 2010 27 3 276 286 20037920 PMC2841221
  30. [37]Pizzagalli DA Goetz E Ostacher M Iosifescu DV Perlis RH Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task Biol. Psychiatry 2008 64 2 162 168 18242583 PMC2464620
  31. [38]Doyle AE Willcutt EG Seidman LJ Attention-deficit/hyperactivity disorder endophenotypes Biol. Psychiatry 2005 57 1324 1335 15950005
  32. [39]Rucklidge JJ Impact of ADHD on the neurocognitive functioning of adolescents with bipolar disorder Biol. Psychiatry 2006 60 921 928 16839520
  33. [43]Braaten EB Rosen LA Self-regulation of affect in attention-deficit hyperactivity disorder (ADHD) and non-ADHD boys: differences in empathic responding J. Consult. Clin. Psychol 2000 68 313 321 10780132
  34. [44]Friedman SR Rapport LJ Lumley M Aspects of social and emotional competence in adult attention-deficit/hyperactivity disorder Neuropsychology 2003 17 1 50 58 12597073
  35. [45]Brotman MA Rich BA Guyer AE Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder Am. J. Psychiatry 2010 167 1 61 69 19917597 PMC3075433 •• First functional MRI (fMRI) study comparing ADHD, PBD and severe mood dysregulation during emotion processing.
  36. [46]Logan GD Cowan WB Davis KA On the ability of inhibit simple and choice reaction time responses: a model and a method J. Exp. Psychol. Hum. Percept. Perform 1984 10 276 291 6232345
  37. [47]Hoeksma JB Osterlaan J Schipper E Emotion regulation and the dynamics of feelings: a conceptual and methodological framework Child Dev 2004 75 2 354 360 15056190
  38. [48]Rubia K Overmeyer S Taylor E Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI Am. J. Psychiatry 1999 156 891 896 10360128
  39. [49]Garavan H Ross TJ Murphy K Roche RA Stein EA Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction Neuroimage 2002 17 1820 1829 12498755
  40. [50]Casey BJ Giedd JN Thomas KM Structural and functional brain development and its relation to cognitive development Biol. Psychol 2000 54 1–3 241 257 11035225
  41. [51]Durston S Thomas KM Worden MS Yang Y Casey BJ The effect of preceding context on inhibition: an event-related fMRI study Neuroimage 2002 2 449 453 12030830
  42. [52]Oosterlaan J Logan GD Sergeant JA Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: a meta-analysis of studies with the stop task J. Child Psychol. Psychiatry 1998 39 3 411 425 9670096
  43. [53]Nigg JT Is ADHD a disinhibitory disorder? Psychol. Bull 2001 127 571 598 11548968
  44. [54]Adams ZW Derefinko KJ Milich R Fillmore MT Inhibitory functioning across ADHD subtypes: recent findings, clinical implications, and future directions Dev. Disabil. Res. Rev 2008 14 4 268 275 19072751 PMC4131681
  45. [55]Fillmore MT Milich R Lorch EP Inhibitory deficits in children with attention-deficit/hyperactivity disorder: intentional versus automatic mechanisms of attention Dev. Psychopathol 2009 21 2 539 554 19338697 PMC12699476
  46. [56]Shaw P Eckstrand K Sharp W Blumenthal J Lerch JP Greenstein D Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation Proc. Natl Acad. Sci. USA 2007 104 19649 19654 18024590 PMC2148343
  47. [57]Sonuga-Barke EJS Sergeant JA Nigg J Willcutt S Executive dysfunction and delay aversion in attention deficit hyperactivity disorder: nosologic and diagnostic implications Child Adolesc. Psychiatry Clin. N. Am 2008 17 367 384 18295151
  48. [59]Castellanos FX Sonuga-Barke EJ Milham MP Tannock R Characterizing cognition in ADHD: beyond executive dysfunction Trends Cogn. Sci 2006 10 117 123 16460990
  49. [61]Solanto MV Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research Behav. Brain Res 2002 130 65 71 11864719
  50. [62]Diamond A Prevor MB Callender G Druin DP Prefrontal cortex cognitive deficits in children treated early and continuously for PKU Monogr. Soc. Res. Child Dev 1997 62 4 i v 1 208 9421921
  51. [63]Sagvolden T Johansen EB Aase H Russell VA A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes Behav. Brain Sci 2005 28 397 419 16209748
  52. [64]Russell VA Sagvolden T Johansen EB Animal models of attention-deficit hyperactivity disorder Behav. Brain Funct 2005 1 9 16022733 PMC1180819
  53. [66]Leibenluft E Rich BA Vinton DT Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder Am. J. Psychiatry 2007 164 52 60 17202544 •• First fMRI study on response inhibition deficits in PBD, which found reduced activation in striatal and ventrolateral prefrontal cortex during failed inhibition trials in PBD relative to healthy controls.
  54. [67]Passarotti AM Sweeney JA Pavuluri MN Neural correlates of response inhibition deficits in pediatric bipolar disorder and attention deficit hyperactivity disorder Psychiatry Res 2010 181 1 36 43 19926457 PMC2795009 •• First fMRI study comparing response inhibition in ADHD and PBD. The results indicate more extensive prefrontal deficits in ADHD relative to PBD in spite of similar attention problems.
  55. [68]Pavuluri MN Passarotti AM Harral EM Sweeney JA Enhanced prefrontal function with pharmacotherapy on a response inhibition task in adolescent bipolar disorder J. Clin. Psychiatry 2010 71 1 9 PMC2994986 20816040
  56. [70]Aron AR Poldrack RA The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder Biol. Psychiatry 2005 57 1285 1292 15950000 •• Excellent review on cognitive neuroscience theories of response inhibition and their relevance for clinical research.
  57. [72]Tillman CM Thorell LB Brocki KC Bohlin G Motor response inhibition and execution in the stop signal task: development and relation to ADHD behaviors Child Neuropsychology 2008 14 1 42 59 17852128
  58. [73]Johnstone SJ Dimoska A Smith JL The development of stop-signal and Go/Nogo response inhibition in children aged 7–12 years: performance and event-related potential indices Int. J.Psychophysiol 2007 63 1 25 38 16919346
  59. [74]Plitzka SR Glahn DC Semrud-Clikeman M Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naïve or in long-term treatment Am. J. Psychiatry 2006 163 6 1052 1060 16741206
  60. [75]Durston S Tottenham NT Thomas KM Differential patterns of striatal activation in young children with and without ADHD Biol. Psychiatry 2003 53 10 871 878 12742674
  61. [76]Durston S Mulder M Casey BJ Ziermans T van Engeland H Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention deficit hyperactivity disorder Biol. Psychiatry 2006 60 1062 1070 16712804 •• fMRI study linking deficits in ventrolateral prefrontal cortex to genetic vulnerability for ADHD.
  62. [77]Tamm L Menon V Ringel J Reiss AL Event-related fMRI evidence of frontotemporal involvement in aberrant response inhibition and task switching in attention-deficit/hyperactivity disorder J. Am. Acad. Child Adolesc. Psychiatry 2004 43 1430 1440 15502603
  63. [81]Pavuluri MN O'Connor MM Harral EM Sweeney JA An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder Psychiatry Res 2008 162 3 244 255 18294820 PMC2323905
  64. [82]Blumberg HP Leung HC Skudlarski P A functional magnetic resonance imaging study of bipolar disorder: state-and trait-related dysfunction in ventral prefrontal cortices Arch. Gen.Psychiatry 2003 60 601 609 12796223
  65. [83]Konishi S Nakajima K Uchida I Kikyo H Kameyama M Miyashita Y Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI Brain 1999 122 981 991 10355680
  66. [84]Alexander GE DeLong MR Strick PL Parallel organization of functionally segregated circuits linking basal ganglia and cortex Annu. Rev. Neurosci 1986 9 357 338 3085570
  67. [85]D'Esposito M Postle BR Rypma B Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies Exp. Brain Res 2000 133 1 3 11 10933205
  68. [86]Pavuluri MN Yang S Kamineni K DTI Study of white matter fiber tracts: in pediatric bipolar disorder and attention deficit hyperactivity disorder Biol. Psychiatry 2009 65 7 586 593 19027102 PMC2677389
  69. [90]Frangou S Haldane M Roddy D Kumari V Evidence for deficit in tasks of ventral, but not dorsal, prefrontal executive function as an endophenotypic marker for bipolar disorder Biol. Psychiatry 2005 58 10 838 839 16043135
  70. [92]Haber SN Knutson B The reward circuit: linking primate anatomy and human imaging Neuropsychopharmacol. Rev 2009 1 23 PMC3055449 19812543
  71. [93]Robbins TW Everitt BJ Neurobehavioural mechanisms of reward and motivation Curr. Opin. Neurobiol 1996 6 228 236 8725965
  72. [94]Rolls ET The orbitofrontal cortex and reward Cerebral Cortex 2000 10 284 294 10731223
  73. [95]McClure SM Laibson DI Lowenstein G Cohen JD Separate neural systems value immediate and delayed monetary rewards Science 2004 306 503 507 15486304
  74. [96]Balleine BW Delgado MR Hikosaka O The role of the dorsal striatum in reward and decision-making J. Neurosci 2007 27 8161 8165 17670959 PMC6673072
  75. [97]Fareri D Martin L Delgado M Reward-related processing in the human brain: Developmental considerations Dev. Psychopathol 2008 20 1191 1211 18838038
  76. [98]Passarotti AM Sweeney JA Pavuluri MN Neural correlates of incidental and directed facial emotion processing in adolescents and adults Soc. Cogn. Affect. Neurosci 2009 4 387 398 20035016 PMC2799953
  77. [102]May JC Delgado MR Dahl RE Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents Biol. Psychiatry 2004 55 359 366 14960288
  78. [104]Eshel N Nelson EE Blair RJ Pine DS Ernst M Neural substrates of choice selection in adults and adolescents: Development of the ventrolateral prefrontal and anterior cingulate cortices Neuropsychologia 2007 45 1270 1279 17118409 PMC2700731
  79. [105]Luman M Oosterlaan J Sergeant JA The impact of reinforcement contingencies on AD/HD: a review and theoretical appraisal Clin. Psychol. Rev 2005 25 2 183 213 15642646
  80. [107]Sonuga-Barke EJS Taylor E Sembi E Smith J Hyperactivity and delay aversion. I. The effect of delay on choice J. Child Psychol. Psychiatry 1992 33 387 398 1564081
  81. [110]Dibbets P Evers L Hurks P Marchetta N Jolles J Differences in feedback- and inhibition- related neural activity in adult ADHD Brain Cogn 2009 70 73 83 19201515
  82. [111]Pavuluri MN O'Connor MM Harral EM Sweeney JA Affective neural circuitry during facial emotion processing in pediatric bipolar disorder Biol. Psychiatry 2007 62 158 167 17097071
  83. [112]Passarotti AM Sweeney JA Pavuluri MN Fronto-limbic dysfunction in mania pre-treatment and persistent amygdala over-activity post-treatment in pediatric bipolar disorder Psychopharmacology (Berl.) 2011 DOI: 10.1007/s00213-011-2243-2 Epub ahead of print PMC3174733 21390505 · DOI
  84. [113]Dickstein DP Finger EC Skup M Pine DS Blair JR Leibenluft E Altered neural function in pediatric bipolar disorder during reversal learning Bipolar Disord 2010 12 7 707 719 21040288 PMC3391027
  85. [114]Abler B Greenhouse I Ongur D Walter H Heckers S Abnormal reward system activation in mania Neuropsychopharmacology 2008 33 9 2217 2227 17987058 PMC2574988
  86. [115]Strakowski SM DelBello MP Fleck DE Arndt S The impact of substance abuse on the course of bipolar disorder Biol. Psychiatry 2000 48 6 477 485 11018221
  87. [117]Pavuluri MN Passarotti AM Neural bases of emotional processing in pediatric bipolar disorder Expert Rev. Neurother 2008 8 9 1381 1387 18759550
  88. [118]Pavuluri MN Passarotti AM Harral EM Sweeney JA An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder J. Am. Acad. Child Adolesc. Psychiatry 2009 48 308 319 19242292 PMC2772656
  89. [119]Tricomi EM Delgado MR Fiez JA Modulation of caudate activity by action contingency Neuron 2004 41 2 281 292 14741108
  90. [122]Bechara A Tranel D Damasio H Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions Brain 2000 123 11 2189 2202 11050020
  91. [123]Knutson B Fong GW Bennett SM Adams CM Homme D A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI Neuroimage 2003 18 263 272 12595181
  92. [124]Hampton AN Adolphs R Tyszka MJ O'Doherty JP Contributions of the amygdala to reward expectancy and choice signals in human prefrontal cortex Neuron 2007 55 4 545 555 17698008
  93. [125]Knutson B Fong GW Adams CS Hommer D Dissociation of reward anticipation versus outcome with event-related fMRI Neuroreport 2001 12 3683 3687 11726774
  94. [127]Carter R MacInnes J Huettel SA Adcock R Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses Front. Behav. Neurosci 2009 3 21 19753142 PMC2742668
  95. [128]Levita L Hare TA Voss HU Glover G Ballon DJ Casey BJ The bivalent side of the nucleus accumbens Neuroimage 2009 44 3 1178 1187 18976715 PMC2659952
  96. [129]Adolphs R Neural systems for recognizing emotion Curr. Opin. Neurobiol 2002 12 169 177 12015233
  97. [131]Salzman CD Paton JJ Belova MA Morrison SE Flexible neural representations of value in the primate brain Ann. NY Acad. Sci 2007 1121 336 354 17872400 PMC2376754
  98. [134]Passarotti AM Ellis J Wegbreit E Varghese B Stevens MC Pavuluri MN Working memory networks are influenced by facial emotions in pediatric bipolar disorder The Pediatric Bipolar Conference Boston, MA, USA 24–25 March (2011)
  99. [138]Leibenluft E Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths Am. J. Psychiatry 2011 168 2 129 142 21123313 PMC3396206
  100. [139]Rich BA Brotman MA Dickstein DP Mitchell DG Blair RJ Leibenluft E Deficits in attention to emotional stimuli distinguish youth with severe mood dysregulation from youth with bipolar disorder J. Abnorm. Child Psychol 2010 38 5 695 706 20180010 PMC2880646
  101. [140]Rau G Blair KS Berghorst L Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation J. Child Adolesc. Psychopharmacol 2008 18 2 185 196 18439115 PMC2683389
  102. [141]Daly BP Creed T Xanthopoulos M Brown RT Psychosocial treatments for children with attention deficit/hyperactivity disorder Neuropsychol. Rev 2007 17 1 73 89 17260167
  103. [143]Fehlings DL Roberts W Humphries T Dawe G Attention deficit hyperactivity disorder: does cognitive behavioral therapy improve home behavior? J. Dev. Behav. Pediatr 1991 12 4 223 228 1939676
  104. [145]Pavuluri MN Graczyk PA Henry DB Carbray JA Heidenreich J Miklowitz DJ Child- and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: development and preliminary results J. Am. Acad. Child Adolesc. Psychiatry 2004 43 5 528 537 15100559
  105. [146]West AE Henry DB Pavuluri MN Maintenance model of integrated psychosocial treatment in pediatric bipolar disorder: a pilot feasibility study J. Am. Acad. Child Adolesc. Psychiatry 2007 46 2 205 212 17242624
  106. [147]West AE Pavuluri MN Psychosocial treatments for childhood and adolescent bipolar disorder Child Adolesc. Psychiatr. Clin. N. Am 2009 18 2 471 482 19264274
  107. [149]Holmes J Gathercole SE Dunning GL Adaptive training leads t osustained enhancement of poor working memory in children Dev. Sci 2009 12 4 F9 15 19635074
  108. [151]Tannock R Attention deficit hyperactivity disorder: advances in cognitive, neurobiological, and genetic research J. Child Psychol. Psychiatry 1998 39 65 99 1998 9534087
  109. [152]Sheridan MA Hinshaw S D'Esposito M Stimulant medication and prefrontal functional connectivity during working memory in ADHD: a preliminary report J. Atten. Disord 2010 14 1 69 78 20576647 PMC2935299
  110. [153]Volkow ND Wang G Fowler JS Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain J. Neurosci 2001 21 2 RC121 11160455 PMC6763805
  111. [154]Wilens TE Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues Psychiatr. Clin. North Am 2004 27 2 283 301 15063998
  112. [155]Vaidya CJ Austin G Kirkorian G Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance imaging study Proc. Natl Acad. Sci. USA 1998 95 14494 14499 9826728 PMC24401
  113. [156]Shafritz KM Marchione KE Gore JC Shaywitz SE Shaywitz BA The effects of methylphenidate on neural systems of attention in attention deficit hyperactivity disorder Am. J. Psychiatry 2004 161 1990 1997 15514398
  114. [157]Rubia K Halari R Cubillo A Mohammad AM Brammer M Taylor E Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task Neuropharmacology 2009 57 7–8 640 652 19715709
  115. [158]Wigal SB Chae S Patel A Steinberg-Epstein R. Advances in the treatment of attention-deficit/hyperactivity disorder: a guide for pediatric neurologists Semin. Pediatr. Neurol 2010 17 4 230 236 21183129
  116. [160]Chen J Fang Y Kemp DE Calabrese JR Gao K Switching to hypomania and mania: differential neurochemical, neuropsychological, and pharmacologic triggers and their mechanisms Curr. Psychiatry Rep 2010 12 6 512 521 20878507
  117. [161]Pavuluri MN Passarotti AM Parnes SA Fitzgerald JM Sweeney JA A pharmacological fMRI study probing the interface of cognitive and emotional brain systems in pediatric bipolar disorder J. Child Adolesc. Psychopharmacol 2010 20 5 395 406 20973710 PMC2982709
  118. [162]Pavuluri MN Passarotti AM Fitzgerald JM Sweeney JA Risperidone and divalproex differentially engange the fronto–striato–temporal circuitry in pediatric mania: a pharmacological fMRI study J. Am. Acad. Child Adolesc. Psychiatry 2011 In press PMC3357915 22265362
  119. [163]Pavuluri MN Passarotti AM Mohammed T Carbray J Sweeney JA Enhanced working and verbal memory after lamotrigine treatment in pediatric bipolar disorder Bipolar Disord 2010 12 2 213 220 20402714 PMC2858356
  120. [164]Pavuluri MN Passarotti AM Lu LH Carbray JA Sweeney JA Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes Psychiatry Res In press PMC3105215 21592741
  121. [165]Kessler RC Berglund P Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national Comorbidity Survey replication Arch. Gen. Psychiatry 2005 62 6 593 602 15939837
  122. [166]Insel TR Foreword. Developmental cognitive neuroscience Dev. Cogn. Neurosci 2011 1 1 2 PMC6989726 22436414
  123. [167]Rich BA Schmajuk M Perez-Edgar KE Fox NA Pine DS Leibenluft E Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulation Am. J. Psychiatry 2007 164 309 317 17267795
  124. [168]Calhoun V Wu L Kiehl K Eichele T Pearlson G Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data Acta Neuropsychiatr 2010 22 3 127 138 21331320 PMC3038634
  125. [169]Stevens MC The developmental cognitive neuroscience of functional connectivity Brain Cogn 2009 70 1 12 19185406
  126. [170]Calhoun VD Maciejewski PK Pearlson GD Kiehl KA Temporal lobe and `default' hemodynamic brain modes discriminate between schizophrenia and bipolar disorder Hum. Brain Mapp 2008 29 11 1265 1275 17894392 PMC2665178
  127. [171]Zhu CZ Zang YF Cao QJ Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder Neuroimage 2008 40 110 120 18191584
  128. [172]Castellanos FX Margulies DS Kelly C Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder Biol. Psychiatry 2008 63 332 337 17888409 PMC2745053
  129. [173]Rich BA Fromm SJ Berghorst LH Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit J Child Psychol. Psychiatry 2008 49 1 88 96 18181882 PMC2721276
  130. [174]Stevens MC Kiehl KA Pearlson GD Calhoun VD Functional neural networks underlying response inhibition in adolescents and adults Behav. Brain Res 2007 181 1 12 22 17467816 PMC2266817
  131. [176]Stein MA Waldman ID Sarampote CS Dopamine transporter genotype and methylphenidate dose–response in children with ADHD Neuropsychopharmacology 2005 30 1374 1382 15827573
  132. [177]Stollstoff MA Foss-Feig J Cook EH Stein MA Gaillard WD Neural response to working memory load varies by dopamine transporter genotype in children Neuroimage 2010 53 970 977 20053379 PMC2888738
  133. [178]MacQueen GM Hajek T Alda M The phenotypes of bipolar disorder: relevance for genetic investigations Mol. Psychiatry 2005 10 9 811 826 15970930
  134. [179]Gau SS Shang CY Executive functions as endophenotypes in ADHD: evidence from the Cambridge Neuropsychological Test Battery (CANTAB) J. Child Psychol. Psychiatry 2010 51 7 838 849 20085608
  135. [180]Fan J Fossella J Sommer T Wu Y Posner MI Mapping the genetic variation of executive attention onto brain activity Proc. Natl Acad. Sci. USA 2003 100 7406 7411 12773616 PMC165888
  136. [182]Kulkarni SK Re-engineering pharmacology teaching and research: can we adopt translational approach? Indian J. Pharmacol 2010 42 5 259 260 21206613 PMC2959204
  137. [183]Zalla T Joyce C Szoke A Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia Psychiatry Res 2004 121 3 207 271 14675740
  138. [184]Ladouceur CD Almeida JR Birmaher B Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder? J. Am. Acad. Child Adolesc. Psychiatry 2008 47 5 532 539 18356765 PMC2711512
  139. [185]Donnelly M Haby MM Carter R Andrews G Vos T Cost-effectiveness of dexamphetamine and metylphenidate for the treatment of childhood attention deficit hyperactivity disorder Aust. NZ J. Psychatry 2004 38 592 601 15298581
  140. [186]Wozniak J Biederman J Mundy E Mennin D Faraone SV A pilot family study of childhood-onset mania J. Am. Acad. Child Adolesc. Psychiatry 2005 34 12 1577 1583 8543528

Authors
Passarotti, A. M., & Pavuluri, M. N.
Affiliations
University of Illinois Chicago (US)
Corresponding author
Passarotti, Alessandra M
ORCID
Pavuluri, Mani N
Venue
Expert Review of Neurotherapeutics
Publisher
Informa UK Limited
Published
2011-06
Volume
11
Issue
6
Pages
897-914
ISSN
  • 1473-7175 (ISSN-L)
  • 1744-8360
DOI
10.1586/ern.11.71
PMC
PMC3129632
OpenAlex
W2000524224
Cited by
44
References
192
Citations by year
2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 11 · 2013: 6 · 2012: 3
FWCI
0.92
Type
journal article
Language
en
Open access
Locations
  • Expert Review of Neurotherapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (RC1MH088462, R01MH081019, R01MH085639)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
attention deficit hyperactivity disorder, pediatric bipolar disorder, impulsivity, reward systems, executive function, response inhibition, behavioral regulation, emotional impulsivity, cognitive impulsivity, goal-directed behavior, neuroimaging, neurocognitive impairment, therapeutic interventions
MeSH terms
Attention Deficit Disorder with Hyperactivity, Bipolar Disorder, Brain, Child, Humans, Phenotype

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review