Natural products from some soil cyanobacterial extracts with potent antimicrobial, antioxidant and cytotoxic activities
Open accessAbstract
The ethyl acetate, n hexane and methanol extracts of six cyanobacterial species isolated from paddy fields in Egypt were assessed for their antimicrobial activity, using disc diffusion method. Oscillatoria acuminata, Oscillatoria amphigranulata and Spirulina platensis methanolic extracts showed the highest inhibition zones. Minimum inhibitory concentration of O. amphigranulata extract recorded lower values using agar streak dilution method. O. acuminata methanolic extract exhibited the highest antioxidant activity (6.58 and 34.60 % using DPPH (2, 2- diphenyl-1- picrylhydrazyl) and ABTS+ (2, 2-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) methods, respectively, followed by O. amphigranulata then S. platensis. Similarly, O. acuminata methanolic extract showed very strong cytotoxicity activity against HepG2 and HCT-116 cell lines and strong activity with MCF-7 cell lines. O. amphigranulata extract showed strong cytotoxicity for HepG2 and HCT-116 as well as moderate cytotoxicity for MCF-7 cell line. Whereas, S. platensis extract exhibited moderate cytotoxicity for all cell lines. Results of gas chromatography/mass spectroscopy analysis pointed out that the potential activity of these cyanobacterial extracts might be attributed to a synergistic effect between their pronounced contents of fatty acids, alkaloids, phytol, hydrocarbons, phenolics and phthalates, especially fatty acids. We recommend cyanobacteria as a rich source of natural products with potent pharmacological and medical applications.
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The methanolic extract of Arthrospira platensis has been shown to have the highest antioxidant and antimicrobial activity.
“The methanolic extract has been shown to have the highest antioxidant and antimicrobial activity [67,68].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [67]
The Antimicrobial activity section says the strongest antifungal and antibacterial effects among the tested extracts were from O. amphigranulata, not S. platensis. The GC-MS analysis section identifies O. acuminata as having the highest antioxidant activity and says S. platensis had lower activity. The copy provides no page numbers for these passages. (LLM, conf=0.90)
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References 47 · Cited by 53
Research works printed but not linked: 3
- ABD EL-KARIM MS. 2016. Chemical composition and antimicrobial activities of cyanobacterial mats from hyper saline lakes, orthern weastern desert. Egypt J Appl Sci 16(1): 1-10.
- MALATHI T, RAMESH BABU M, MOUNIKA T, SNEHALATHA D & DIGAMBER RAO B. 2014. Screening of cyanobacterial strains for antibacterial activity. Phykos 44(2): 446-451.
- VARSHNEY A & SINGH V. 2013. Effect of algal compounds on cancer cell line. J Experimental Biol Agr Sci 1(5): 338-352.
- Authors
- GHEDA, S. F., & ISMAIL, G. A.
- Affiliations
- Tanta University (EG)
- Venue
- Anais da Academia Brasileira de Ciências
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2020
- Volume
- 92
- Issue
- 2
- Pages
- e20190934-e20190934
- ISSN
- 0001-3765 (ISSN-L)
- 1678-2690
- OpenAlex
- W3048265916
- Cited by
- 53
- References
- 47
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 11 · 2023: 11 · 2022: 6 · 2021: 8
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Anais da Academia Brasileira de Ciências (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Biocrusts and Microbial Ecology
- Keywords
- soil cyanobacteria, natural products, antimicrobial activity, antioxidant activity, cytotoxicity, Spirulina platensis, fatty acids, phenolic compounds, phthalates, HepG2 cells, HCT116 cells, MCF-7 cells, minimum inhibitory concentration
- MeSH terms
- Cyanobacteria, Anti-Infective Agents, Antioxidants, Biological Products, Plant Extracts, Soil
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