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Erythrocytes morphology and hemorheology in severe bacterial infection

Silva, Ayrles FB, Sousa, Jeanlex S, Cunha, Pablyana LR, Lima-Filho, José V, Alencar, Nylane MN, Freitas, Cleverson DT, Oliveira, Claudio LN, Ramos, Marcio V·2019·Memórias do Instituto Oswaldo Cruz
DOI 10.1590/0074-02760190326PMC PMC6917465
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Fig. 1: effects of bacterial infection on whole blood viscosity and red blood cells (RBCs) morphology. (A) Rheogram (top) and viscosity curve profile (bottom) of blood from healthy and infected animals. Flow curves in the rheogram illustrate shear stress (τ; Pa) vs shear rate (γ; s-1) and viscosity curves illustrate dynamic viscosity (η; Pa*s) vs shear stress (γ; s-1). These data (symbols) are then fitted with the Bingham fluid behaviour (solid lines) to calculate blood rheological parameters (shown in Table I). Error bars are smaller than the symbols. (B-C) Atomic force microscopy images of whole blood from healthy mice. (D-E) Atomic force microscopy images of whole blood from animals infected with Salmonella Typhimurium (107 CFU / mL) whose blood was analysed 24 h post challenge.
Fig. 1: effects of bacterial infection on whole blood viscosity and red blood cells (RBCs) morphology. (A) Rheogram (top) and viscosity curve profile (bottom) of blood from healthy and infected animals. Flow curves in the rheogram illustrate shear stress (τ; Pa) vs shear rate (γ; s-1) and viscosity curves illustrate dynamic viscosity (η; Pa*s) vs shear stress (γ; s-1). These data (symbols) are then fitted with the Bingham fluid behaviour (solid lines) to calculate blood rheological parameters (shown in Table I). Error bars are smaller than the symbols. (B-C) Atomic force microscopy images of whole blood from healthy mice. (D-E) Atomic force microscopy images of whole blood from animals infected with Salmonella Typhimurium (107 CFU / mL) whose blood was analysed 24 h post challenge.CC BY · PubMed Central
Fig. 2: different features observed in the whole blood from infected animals using atomic force microscopy. (A) Whole blood topography micrograph from mice infected with Salmonella Typhimurium (107 CFU / mL). (B) Activated platelet with pseudopodia formation. (C) S. Typhimurium in the blood of the animal.
Fig. 2: different features observed in the whole blood from infected animals using atomic force microscopy. (A) Whole blood topography micrograph from mice infected with Salmonella Typhimurium (107 CFU / mL). (B) Activated platelet with pseudopodia formation. (C) S. Typhimurium in the blood of the animal.CC BY · PubMed Central
Fig. 3: hemorheology of healthy animals administrated with Calotropis procera proteins (CpLP). (A) Rheogram (top) and viscosity curve profile (bottom) of blood from mice that received CpLP (30 mg / kg) and whose blood was analysed after different time of exposure. (B) Rheogram (top) and viscosity curve profile (bottom) of blood from healthy animals that received CpLP plus iodoacetamide (30 mg / kg). Flow curves in the rheogram illustrate shear stress (τ; Pa) vs shear rate (γ; s-1) and viscosity curves illustrate dynamic viscosity (η; Pa*s) vs shear stress (γ; s-1). Solid lines show the respective fit of measured data (shown in symbols) with the Bingham fluid behaviour to calculate blood rheological parameters (shown in Table I). Error bars are smaller than the symbols.
Fig. 3: hemorheology of healthy animals administrated with Calotropis procera proteins (CpLP). (A) Rheogram (top) and viscosity curve profile (bottom) of blood from mice that received CpLP (30 mg / kg) and whose blood was analysed after different time of exposure. (B) Rheogram (top) and viscosity curve profile (bottom) of blood from healthy animals that received CpLP plus iodoacetamide (30 mg / kg). Flow curves in the rheogram illustrate shear stress (τ; Pa) vs shear rate (γ; s-1) and viscosity curves illustrate dynamic viscosity (η; Pa*s) vs shear stress (γ; s-1). Solid lines show the respective fit of measured data (shown in symbols) with the Bingham fluid behaviour to calculate blood rheological parameters (shown in Table I). Error bars are smaller than the symbols.CC BY · PubMed Central
Fig. 4: effects of Calotropis procera proteins (CpLP) treatment on whole blood viscosity and red blood cells (RBCs) morphology from infected animals. (A) Rheogram (top) and viscosity curve profile (bottom) of blood from infected animals treated with CpLP (30 mg / kg). Flow curves in the rheogram illustrate shear stress (τ; Pa) vs shear rate (γ; s-1) and viscosity curves illustrate dynamic viscosity (η; Pa*s) vs shear stress (γ; s-1). These data (symbols) are fitted with the Bingham fluid behaviour (solid lines) to calculate blood rheological parameters (shown in Table I). Error bars are smaller than the symbols. (B-C) Atomic force microscopy images of whole blood from healthy mice that received CpLP (30 mg / kg) and whose blood was analysed 24 h after exposure. (D-E) Atomic force microscopy views of whole blood from animals pre-treated with CpLP (30 mg / kg) and infected with Salmonella Typhimurium. These animals had the blood analysed 24 h after infection.
Fig. 4: effects of Calotropis procera proteins (CpLP) treatment on whole blood viscosity and red blood cells (RBCs) morphology from infected animals. (A) Rheogram (top) and viscosity curve profile (bottom) of blood from infected animals treated with CpLP (30 mg / kg). Flow curves in the rheogram illustrate shear stress (τ; Pa) vs shear rate (γ; s-1) and viscosity curves illustrate dynamic viscosity (η; Pa*s) vs shear stress (γ; s-1). These data (symbols) are fitted with the Bingham fluid behaviour (solid lines) to calculate blood rheological parameters (shown in Table I). Error bars are smaller than the symbols. (B-C) Atomic force microscopy images of whole blood from healthy mice that received CpLP (30 mg / kg) and whose blood was analysed 24 h after exposure. (D-E) Atomic force microscopy views of whole blood from animals pre-treated with CpLP (30 mg / kg) and infected with Salmonella Typhimurium. These animals had the blood analysed 24 h after infection.CC BY · PubMed Central

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Research works printed but not linked: 25

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Authors
Silva, A. F., Sousa, J. S., Cunha, P. L., Lima-Filho, J. V., Alencar, N. M., Freitas, C. D., Oliveira, C. L., & Ramos, M. V.
Venue
Memórias do Instituto Oswaldo Cruz
Publisher
FapUNIFESP (SciELO)
Published
2019
Volume
114
ISSN
  • 1678-8060
  • 0074-0276
DOI
10.1590/0074-02760190326
PMC
PMC6917465
Cited by
17
References
1
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CoChat. (2026). Citation check: Erythrocytes morphology and hemorheology in severe bacterial infection. https://app.cochat.ai/papers/10.1590/0074-02760190326
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Silva, A. F., Sousa, J. S., Cunha, P. L., Lima-Filho, J. V., Alencar, N. M., Freitas, C. D., Oliveira, C. L., & Ramos, M. V. (2019). Erythrocytes morphology and hemorheology in severe bacterial infection. Memórias do Instituto Oswaldo Cruz. https://doi.org/10.1590/0074-02760190326