Development of Intracanal Formulation Containing Silver Nanoparticles
Open accessAbstract
This study aimed to synthetize, characterize and evaluate the antimicrobial properties of silver nanoparticles to be used in the development of a root intracanal formulation. Silver nanoparticles (AgNPs) were obtained by reduction of silver nitrate with sodium borohydride and characterized by UV-Visible spectrophotometry, scanning electron microscopy (SEM) and dynamic light scattering (DLS). The antimicrobial activity of nanoparticle formulation was evaluated by determinations of the minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against different bacterial species by the microdilution method, according to recommendations of the Clinical and Laboratory Standards Institute (CLSI). Three potential vehicles, hydroxyethylcellulose, Carbomer and polyethylene glycol were tested as carriers for formulations containing AgNPs. The efficiency of the synthesis method chosen to produce AgNPs was demonstrated by four characterization techniques. The nanoparticles showed antibacterial activity against all species tested. Incorporation of AgNPs into all experimental vehicles produced stable formulations but the one in hydroxyethylcellulose presented better physical proprieties. The results indicate that silver nanoparticles are potential antiseptic agents to be used in root canals and incorporation in adequate vehicles may favor a broader application.
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Solid lipid nanoparticles of silver facilitated improved antimicrobial action.
“Likewise, improved antimicrobial action was facilitated by solid lipid nanoparticles of silver [84].”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [84]
A polymeric nanocapsule filled with chlorhexidine and possessing enhanced antibacterial action was created using the interfacial deposition technique.
“By using the interfacial deposition technique, a polymeric nano capsule filled with chlorhexidine and possessing enhanced antibacterial action was created.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [84]
Silver and chlorhexidine gluconate added to nano-formulations have stronger antibacterial properties.
“Particularly, substances, such as silver and chlorhexidine gluconate have been added to nano-formulations that have stronger antibacterial properties.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [84]
Different nanomaterials and chemicals, such as silver, bare titanium dioxide, and chlorhexidine gluconate, have been employed as antiseptics in nano formulations.
“The field of antiseptics has utilized different nanomaterials, and several chemicals, such as silver, bare Titanium Dioxide (TiO2), and chlorhexidine gluconate, have been employed as antiseptics in nano formulations.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [84]
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References 25 · Cited by 33
- Authors
- Bruniera, J. F. B., Silva-Sousa, Y. T. C., Lara, M. G., Pitondo-Silva, A., Marcaccini, A. M., & Miranda, C. E. S.
- Affiliations
- Universidade de Ribeirão Preto (BR)
- University of Ribeirão Preto, Brazil
- Universidade de São Paulo (BR)
- USP - University of São Paulo, Brazil
- Venue
- Brazilian Dental Journal
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2014
- Volume
- 25
- Issue
- 4
- Pages
- 302-306
- ISSN
- 0103-6440 (ISSN-L)
- OpenAlex
- W1971250033
- Cited by
- 33
- References
- 25
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Dental Journal (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidade de São Paulo
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- silver nanoparticles, root canal disinfection, antimicrobial activity, sodium borohydride reduction, hydroxyethyl cellulose, Carbopol, polyethylene glycol, vehicle selection, minimum inhibitory concentration, minimum bactericidal concentration, endodontics
- MeSH terms
- Microbial Sensitivity Tests, Silver, Metal Nanoparticles
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