Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats
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Abstract Aim Obesity during pregnancy is one of the most established risk factors for negative long-term programming. The aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during pregnancy and lactation on the weight gain, visceral adipose tissue and cholesterolemia in neonatal rats. Methods Wistar rats were divided into two groups according to the mother's diet during pregnancy and lactation: Control group (CG, n = 12) were the offspring of rats fed a standard diet (4% lipid) and the Test group (TG, n = 12) were pups rats fed on a high fat diet (23% lipid). The weight of the animals was measured on alternate days until the 22nd day of life, when collected visceral adipose tissue and blood were collected for biochemical analysis. For statistical analysis the Student t test, Sidak´s teste and two way ANOVA was used, with p <0.05. Results the test group showed differences in weight gain, visceral adipose tissue and higher cholesterol. Conclusion a maternal exposure to a high-fat diet during pregnancy and lactation can promote changes in weight gain, hypercholesterolemia and an increase in adipose tissue in neonatal rats.
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Offspring from obese/high-fat diet-fed mothers show increased adiposity and adipocyte hypertrophy postnatally.
“Offspring from obese/high-fat diet-fed mothers show increased adiposity [88–90] and adipocyte hypertrophy postnatally [89, 91].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [90]
Cites
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Abraham, T. M., Pedley, A., Massaro, J. M., Hoffmann, U., & Fox, C. S. (2015) · Circulation · doi:10.1161/circulationaha.114.015000 · Cited by 353 · see citing works
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Developmental programming of offspring adipose tissue biology and obesity risk
Rodgers, A., & Sferruzzi-Perri, A. N. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00790-w · Cited by 57 · see citing works
- Authors
- Lima, M. S., Perez, G. S., Morais, G. L., Santos, L. S., Cordeiro, G. S., Couto, R. D., Deiró, T. C. B. J., Leandro, C. G., & Barreto-Medeiros, J. M.
- Affiliations
- Universidade Federal da Bahia (BR)
- Universidade Federal de Pernambuco (BR)
- Universidade Federal da Bahia, Brazil
- ORCID
- Venue
- Brazilian Journal of Biology
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2018-01-08
- Volume
- 78
- Issue
- 4
- Pages
- 615-618
- ISSN
- 1519-6984 (ISSN-L)
- 1678-4375
- OpenAlex
- W2783334007
- Cited by
- 15
- References
- 3
- Citations by year
- 2024: 4 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Brazilian Journal of Biology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- The Scientific Electronic Library Online (Fundação de Amparo à Pesquisa do Estado de São Paulo) (submittedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Division of Graduate Education
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- maternal high-fat diet, maternal obesity, pregnancy, lactation, neonatal rats, visceral adipose tissue, hypercholesterolemia, total cholesterol, neonatal weight gain, developmental programming, fetal programming
- MeSH terms
- Adipose Tissue, Animals, Animals, Newborn, Cholesterol, Disease Models, Animal, Female, Lactation, Lipids, Obesity, Pregnancy, Pregnancy, Animal, Prenatal Exposure Delayed Effects, Rats, Wistar, Rats, Diet, High-Fat
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