Estrogen signaling in the proliferative endometrium: implications in endometriosis
Open accessAbstract
Even though the physiological role of estrogen in the female reproductive cycle and endometrial proliferative phase is well established, the signaling pathways by which estrogen exerts its action in the endometrial tissue are still little known. In this regard, advancements in cell culture techniques and maintenance of endometrial cells in cultures enabled the discovery of new signaling mechanisms activated by estrogen in the normal endometrium and in endometriosis. This review aims to present the recent findings in the genomic and non-genomic estrogen signaling pathways in the proliferative human endometrium specifically associated with the pathogenesis and development of endometriosis.
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In the endometrium of women with endometriosis, several hundred minor biochemical changes have been described.
“In the endometrium of women with endometriosis several hundred minor biochemical changes have been described (124-128).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [128]
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References 49 · Cited by 21
Research works printed but not linked: 3
- Bondza PK, Maheux R, Akoum A. Insights into endometriosis-associated endometrial dysfunctions: a review. Front Biosci (Elite Ed) 2009;1:415-28.
- McDonnell DP, Norris JD. Connections and regulation of the human estrogen receptor. Science 2002;296(5573):1642-4.
- Yotova IY, Quan P, Leditznig N, Beer U, Wenzl R, Tschugguel W. Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis. Hum Reprod 2011;26(4):885-97.
- Authors
- Silva, R. D. C. P. D. C. E., Moura, K. K. V. D. O., Ribeiro Júnior, C. L., & Guillo, L. A.
- Affiliations
- Pontifícia Universidade Católica de Goiás (BR)
- PUC/Goiás, Brazil
- Universidade de São Paulo, Brazil
- Venue
- Revista da Associação Médica Brasileira
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2016-02
- Volume
- 62
- Issue
- 1
- Pages
- 72-77
- ISSN
- 0004-5241 (ISSN-L)
- 0104-4230
- OpenAlex
- W2315496447
- Cited by
- 21
- References
- 49
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Revista da Associação Médica Brasileira (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- estrogen signaling, endometriosis, proliferative endometrium, genomic estrogen signaling, non-genomic estrogen signaling, endometrial cells, endometriosis pathogenesis, female reproductive cycle
- MeSH terms
- Endometriosis, Endometrium, Estrogens, Female, Humans, Receptors, Estrogen, Signal Transduction, Intracellular Signaling Peptides and Proteins
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