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Cited by 23Gestational Diabetes Research and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsBirth, Development, and Health

Maternal 75-g OGTT glucose levels as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus

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Brankica, Krstevska, Valentina, Velkoska Nakova, Slagjana, Simeonova Krstevska, Sasha, Jovanovska Mishevska·2016·Archives of Endocrinology and Metabolism
DOI 10.1590/2359-3997000000126PMC PMC10118908
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Abstract

OBJECTIVE: Our goal was to investigate which glucose measurement from the 75-g oral glucose tolerance test (OGTT) has more capability of predicting large for-gestational-age (LGA) newborns of mothers with gestational diabetes mellitus (GDM). SUBJECTS AND METHODS: The study group consisted of 118 consecutively pregnant women with singleton pregnancy, patients of Outpatients Department of the Endocrinology, Diabetes, and Metabolic Disorders Clinic. All were prospectively screened for GDM between 24th and 28th week of pregnancy and followed to delivery. Outcome measures included: patients' ages, pre-pregnancy BMI, BMI before delivery, FPG, 1 and 2 hour OGTT glucose values, haemoglobin A1c at third trimester, gestational week of delivery, mode of delivery and baby birth weight. RESULTS: From 118 pregnancies, 78 (66.1%) women were with GDM, and 40 (33.9%) without GDM. There were statistically significant differences (30.7 versus 5.0%, p < 0.01) between LGA newborns from GDM and control group, respectively. Gestation week of delivery and fasting glucose levels were independent predictors for LGA (Beta = 0.58 and Beta = 0.37 respectively, p < 0.01). Areas under the receiver operator characteristic curve (AUC) were compared for the prediction of LGA (0.782 (0.685-0.861) for fasting, 0.719 (0.607-0.815) for 1-hour and 0.51 (0.392-0.626) for 2-hour OGTT plasma glucose levels). CONCLUSION: Fasting and 1-hour plasma glucose levels from OGTT may predict LGA babies in GDM pregnancies.

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  • In Macedonia/Northern Macedonia, the only article presenting GDM prevalence assessed incidence at 66.1%.

    “The only article, that presented the GDM prevalence in Macedonia/Northern Macedonia assessed the incidence at 66.1% [193].”

    From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [193]

    The Results report that 78 of 118 women (66.1%) screened in Skopje had GDM. But the Subjects and Methods describe a single-hospital sample, and the Discussion says it was enriched for women with GDM risk factors; the figure is not established as national prevalence or incidence. The paper also does not establish that it was the only article reporting GDM prevalence in Macedonia/Northern Macedonia. (LLM, conf=0.89)

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Research works printed but not linked: 24

  1. [1].American College of Obstetricians and Gynecologists Committee on Practice Bulletins – Obstetrics. ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 30, September 2001 (replaces Technical Bulletin Number 200, December 1994). Gestational diabetes. Obstet Gynecol. 2001;98(3):525-38. 11547793
  2. [2].Evagelidou EN, Kiortsis DN, Bairaktari ET, Giapros VI, Cholevas VK, Tzallas CS, et al. Lipid profile, glucose homeostasis, blood pressure, and obesity-anthropometric markers in macrosomic offspring of nondiabetic mothers. Diabetes Care. 2006;29(6):1197-201. 16731995
  3. [3].Snyder J, Gray-Donald K, Koski KG. Predictors of infant birth weight in gestational diabetes. Am J Clin Nutr. 1994;59(6):1409-14. 8198068
  4. [4].Kabali C, Werler MM. Pre-pregnant body mass index, weight gain and the risk of delivering large babies among non-diabetic mothers. Int J Gynaecol Obstet. 2007;97(2):100-4. PMC1964793 17376448
  5. [6].HAPO Study Cooperative Research Group, Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991-2002. 18463375
  6. [7].International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676-82. PMC2827530 20190296
  7. [8].Metzger BE, Coustan DR. Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing Committee. Diabetes Care. 1998;21 Suppl 2:B161-7. 9704245
  8. [9].Black MH, Sacks DA, Xiang AH, Lawrence JM. Clinical outcomes of pregnancies complicated by mild gestational diabetes mellitus differ by combinations of abnormal oral glucose tolerance test values. Diabetes Care. 2010;33(12):2524-30. PMC2992182 20843973
  9. [10].Ferrara A, Weiss NS, Hedderson MM, Quesenberry CP Jr, Selby JV, Ergas IJ, et al. Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirubinaemia. Diabetologia. 2007;50(2):298-306. 17103140
  10. [11].Caulfield LE, Harris SB, Whalen EA, Sugamori ME. Maternal nutritional status, diabetes and risk of macrosomia among Native Canadian women. Early Hum Dev. 1998;50(3):293-303. 9548033
  11. [12].Kösüs N, Kösüs A, Duran M, Turhan NO. Effect of number of abnormal oral glucose tolerance test (OGTT) values on birth weight in women with gestational diabetes. Indian J Med Res. 2013;137(1):95-101. PMC3657905 23481057
  12. [14].Yang YD, Zhai GR, Yang HX. [Factors relevant to newborn birth weight in pregnancy complicated with abnormal glucose metabolism]. Zhonghua Fu Chan Ke Za Zhi. 2010;45(9):646-51. 21092542
  13. [15].Krstevska B, Velkoska Nakova V, Adamova G, Simeonova S, Dimitrovski Ch, Livrinova V, et al. Association between foetal growth and different maternal metabolic characteristics in women with gestational diabetes mellitus. Prilozi. 2009;30(2):103-14. 20087253
  14. [16].Krstevska B, Mishevska S, Janevska E, Simeonova S, Livrinova V, Pemovska G, et al. Gestational Diabetes Mellitus – the impact of maternal body mass index and glycaemic control on baby’s birth weight. Prilozi. 2009;30(2):115-24. 20087254
  15. [17].Charlotte MB, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity and gestational diabetes mellitus. Pediatrics. 2005;115(3):e290-6. 15741354
  16. [18].Johnstone FD, Mao JH, Steel JM, Prescott RJ, Hume R. Factors affecting fetal weight distribution in women with type I diabetes. BJOG. 2000;107(8):1001-6. 10955432
  17. [19].Penney GC, Mair G, Pearson DW. The relationship between birth weight and maternal glycated haemoglobin (HbA1c) concentration in pregnancies complicated by Type 1 diabetes. Diabet Med. 2003;20(2):162-6. 12581270
  18. [20].Lowe LP, Metzger BE, Dyer AR, Lowe J, McCance DR, Lappin TR, et al.; HAPO Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations of maternal A1C and glucose with pregnancy outcomes. Diabetes Care. 2012;35(3):574-80. PMC3322718 22301123
  19. [21].Ouzilleau C, Roy MA, Leblanc L, Carpentier A, Maheux P. An observational study comparing 2-hour 75-g oral glucose tolerance with fasting plasma glucose in pregnant women: both poorly predictive of birth weight. CMAJ. 2003;168(4):403-9. PMC143544 12591779
  20. [22].Mello G, Parretti E, Cioni R, Lucchetti R, Carignani L, Martini E, et al. The 75-gram glucose load in pregnancy: relation between glucose levels and anthropometric characteristics of infants born to women with normal glucose metabolism. Diabetes Care. 2003;26(4):1206-10. 12663598
  21. [23].Perucchini D, Fischer U, Spinas GA, Huch R, Huch A, Lehmann R. Using fasting plasma glucose concentrations to screen for gestational diabetes mellitus: prospective population based study. BMJ. 1999;319(7213):812-5. PMC314206 10496823
  22. [24].Schaefer-Graf UM, Heuer R, Kilavuz O, Pandura A, Henrich W, Vetter K. Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes. J Perinat Med. 2002;30(4):313-21. 12235720
  23. [25].Kautzky-Willer A, Bancher-Todesca D, Weitgasser R, Prikoszovich T, Steiner H, Shnawa N, al. The impact of risk factors and more stringent diagnostic criteria of gestational diabetes on outcomes in central European women. J Clin Endocrinol Metab. 2008;93(5):1689-95. 18285407
  24. [26].Retnakaran R, Qi Y, Sermer M, Connelly PW, Hanley AJ, Zinman B. The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: implications for the diagnostic criteria for gestational diabetes. J Clin Endocrinol Metab. 2009;94(3):840-5. PMC2877113 19066293

Cited by

Sorted by citations

Authors
Brankica, K., Valentina, V. N., Slagjana, S. K., & Sasha, J. M.
Affiliations
  • Medical Faculty, R. Macedonia
  • Goce Delcev University (MK)
Venue
Archives of Endocrinology and Metabolism
Publisher
Archives of Endocrinology and Metabolism
Published
2016-02
Volume
60
Issue
1
Pages
36-41
ISSN
2359-3997 (ISSN-L)
DOI
10.1590/2359-3997000000126
PMC
PMC10118908
OpenAlex
W29511877
Cited by
23
References
1
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2
FWCI
3.88
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Archives of Endocrinology and Metabolism (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
gestational diabetes mellitus, large for gestational age, oral glucose tolerance test, fasting blood glucose, birth weight prediction, mode of delivery, gestational age at delivery
MeSH terms
Adult, Birth Weight, Blood Glucose, Female, Fetal Macrosomia, Gestational Age, Glucose Tolerance Test, Humans, Infant, Newborn, Predictive Value of Tests, Pregnancy, Prospective Studies, Risk Factors, ROC Curve, Body Mass Index, Diabetes, Gestational, Body Size

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