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Cited by 490

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Coexistence of potentiation and fatigue in skeletal muscle

Open access
Rassier, D.E., MacIntosh, B.R.·2000·Brazilian Journal of Medical and Biological Research
DOI 10.1590/s0100-879x2000000500003
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Abstract

Twitch potentiation and fatigue in skeletal muscle are two conditions in which force production is affected by the stimulation history. Twitch potentiation is the increase in the twitch active force observed after a tetanic contraction or during and following low-frequency stimulation. There is evidence that the mechanism responsible for potentiation is phosphorylation of the regulatory light chains of myosin, a Ca2+-dependent process. Fatigue is the force decrease observed after a period of repeated muscle stimulation. Fatigue has also been associated with a Ca2+-related mechanism: decreased peak Ca2+ concentration in the myoplasm is observed during fatigue. This decrease is probably due to an inhibition of Ca2+ release from the sarcoplasmic reticulum. Although potentiation and fatigue have opposing effects on force production in skeletal muscle, these two presumed mechanisms can coexist. When peak myoplasmic Ca2+ concentration is depressed, but myosin light chains are relatively phosphorylated, the force response can be attenuated, not different, or enhanced, relative to previous values. In circumstances where there is interaction between potentiation and fatigue, care must be taken in interpreting the contractile responses.

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Metadata

Authors
Rassier, D. E., & MacIntosh, B. R.
Venue
Brazilian Journal of Medical and Biological Research
Publisher
FapUNIFESP (SciELO)
Published
2000-05
Volume
33
Issue
5
Pages
499-508
ISSN
0100-879X (ISSN-L)
DOI
10.1590/s0100-879x2000000500003
OpenAlex
W2145585224
Cited by
490
References
40
FWCI
1.13
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Coexistence of potentiation and fatigue in skeletal muscle. https://app.cochat.ai/papers/10.1590/s0100-879x2000000500003
The paper
Rassier, D. E., & MacIntosh, B. R. (2000). Coexistence of potentiation and fatigue in skeletal muscle. Brazilian Journal of Medical and Biological Research. https://doi.org/10.1590/s0100-879x2000000500003

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.