The husk fiber of Cocos nucifera L. (Palmae) is a source of anti-neoplastic activity
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In the present study, we investigated the in vitro anti-tumoral activities of fractions from aqueous extracts of the husk fiber of the typical A and common varieties of Cocos nucifera (Palmae). Cytotoxicity against leukemia cells was determined by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Cells (2 x 10(4)/well) were incubated with 0, 5, 50 or 500 microg/mL high- or low-molecular weight fractions for 48 h, treated with MTT and absorbance was measured with an ELISA reader. The results showed that both varieties have almost similar antitumoral activity against the leukemia cell line K562 (60.1 +/- 8.5 and 47.5 +/- 11.9% for the typical A and common varieties, respectively). Separation of the crude extracts with Amicon membranes yielded fractions with molecular weights ranging in size from 1-3 kDa (fraction A) to 3-10 kDa (fraction B) and to more than 10 kDa (fraction C). Cells were treated with 500 microg/mL of these fractions and cytotoxicity was evaluated by MTT. Fractions ranging in molecular weight from 1-10 kDa had higher cytotoxicity. Interestingly, C. nucifera extracts were also active against Lucena 1, a multidrug-resistant leukemia cell line. Their cytotoxicity against this cell line was about 50% (51.9 +/- 3.2 and 56.3 +/- 2.9 for varieties typical A and common, respectively). Since the common C. nucifera variety is extensively cultured in Brazil and the husk fiber is its industrial by-product, the results obtained in the present study suggest that it might be a very inexpensive source of new antineoplastic and anti-multidrug resistant drugs that warrants further investigation.
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In both varieties, the antitumoral activity was concentrated in fractions with molecular weights between 1 and 10 kDa.
“In both varieties, the antitumoral activity was concentrated in fractions with molecular weights between 1 and 10 kDa (63).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [63]
Both varieties of C. nucifera husk fiber aqueous extracts showed cytotoxicity against K562 cells and decreased by 50% the viability and anti-MDR activity of Lucena 1 cells.
“Both varieties showed cytotoxicity against K562 cells and decreased by 50% the viability and anti-MDR activity of Lucena 1 cells.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [63]
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References 18 · Cited by 36
- Authors
- Koschek, P. R., Alviano, D. S., Alviano, C. S., & Gattass, C. R.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Venue
- Brazilian Journal of Medical and Biological Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2007-07-31
- Volume
- 40
- Issue
- 10
- Pages
- 1339-1343
- ISSN
- 0100-879X (ISSN-L)
- 1414-431X
- OpenAlex
- W2036207606
- Cited by
- 36
- References
- 18
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 1 · 2013: 3
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- The Scientific Electronic Library Online (Fundação de Amparo à Pesquisa do Estado de São Paulo) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Financiadora de Estudos e Projetos
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Cocos nucifera, coconut husk fiber, anticancer activity, cytotoxicity, leukemia, K562 cells, multidrug resistance, molecular weight fractions, aqueous extract, industrial by-products
- MeSH terms
- Antineoplastic Agents, Phytogenic, Cocos, Drug Screening Assays, Antitumor, Humans, Plant Extracts, Drug Resistance, Neoplasm, K562 Cells
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