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Diphenyl diselenide a janus-faced molecule
Open accessAbstract
In this review, we summarized the potential role of synthetic organoseleno compounds as therapeutic or toxic agents, giving emphasis almost exclusively to diphenyl diselenide, the simplest of the diaryl diselenides, and some of its analogs. We presented the main molecular aspects related to the in vitro toxicity and pharmacology of diphenyl diselenide and also provided in vivo data indicating that the interaction of diphenyl diselenide with thiols can dictate either its toxicological or pharmacological property. The papers covered in this review indicate that a limited activation of the "toxic pathway", i.e., a controlled oxidation of specific high molecular weight thiol-containing molecules could contribute to the pharmacological effects of diphenyl diselenide. In conclusion, this review reinforces the necessity of developing new diorganoyl diselenides that could interact with specific molecular targets.
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Cited by
Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds
Nogueira, C. W., & Rocha, J. B. T. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0720-3 · Cited by 477
Self-citationOxidative stress in MeHg-induced neurotoxicity
Farina, M., Aschner, M., & Rocha, J. B. T. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.05.001 · Cited by 342
Self-citationXu, J., Chu, T., Yu, T., Li, N., Wang, C., Li, C., Zhang, Y., Meng, H., & Nie, G. (2022) · ACS Nano · doi:10.1021/acsnano.2c05558 · Cited by 265
Hassan, W., Barroso Silva, C., Mohammadzai, I. U., Teixeira da Rocha, J., & Landeira-Fernandez, J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120232135 · Cited by 100
Straliotto, M. R., Hort, M. A., Fiuza, B., Rocha, J. B. T., Farina, M., Chiabrando, G., & de Bem, A. F. (2013) · Biochimie · doi:10.1016/j.biochi.2013.04.008 · Cited by 36
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Metadata
- Authors
- Nogueira, C. W., & Rocha, J. B. T.
- Venue
- Journal of the Brazilian Chemical Society
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2010
- Volume
- 21
- Issue
- 11
- Pages
- 2055-2071
- ISSN
- 0103-5053 (ISSN-L)
- OpenAlex
- W2161916112
- Cited by
- 232
- References
- 0
- FWCI
- 31.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nogueira, C. W., & Rocha, J. B. T. (2010). Diphenyl diselenide a janus-faced molecule. Journal of the Brazilian Chemical Society. https://doi.org/10.1590/s0103-50532010001100006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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