Actinic keratosis: a clinical and epidemiological revision
Open accessAbstract
Actinic keratoses are benign intraepithelial skin neoplasms constituted by atypical proliferation of keratinocytes that may evolve to squamous cell carcinoma. They develop in photoexposed skin areas; they are induced mainly by ultraviolet radiation and are considered cutaneous markers of chronic exposure to sunlight. They develop mainly in adults and older, fair skinned individuals, and are the fourth most common cause of dermatologic consultation in Brazil. Damage to the apoptosis pathway in photoexposed epithelium favors cellular proliferation and the permanence of the lesions. In this revision, the authors assemble the main epidemiological data regarding this disease and suggest that strategies to identify risky phenotypes, early diagnosis, adequate treatment, clinical follow-up, stimulus to skin self examination, photoeducation and photoprotection should be promoted with the aim of avoiding the progression to malignancy and also the prevention and the diagnose of concomitant neoplasms also induced by ultraviolet radiation.
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A meta-analysis showed that smoking was associated with SCC, whose main risk factor is UV exposure.
“Moreover, a meta‐analysis58 showed that smoking was associated with SCC, whose main risk factor is UV exposure.59”
From The impact of airborne pollution on skin (2019) · cites this paper as [59]
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References 132 · Cited by 120
Research works printed but not linked: 10
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- Authors
- Schmitt, J. V., & Miot, H. A.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Venue
- Anais Brasileiros de Dermatologia
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2012-06
- Volume
- 87
- Issue
- 3
- Pages
- 425-434
- ISSN
- 0365-0596 (ISSN-L)
- OpenAlex
- W1995629059
- Cited by
- 120
- References
- 132
- Citations by year
- 2025: 5 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 6 · 2020: 7 · 2019: 14 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 3
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Anais Brasileiros de Dermatologia (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
- Keywords
- actinic keratosis, squamous cell carcinoma, ultraviolet radiation, keratinocyte proliferation, apoptosis, sun exposure, skin cancer prevention, photoprotection, skin self-examination, early diagnosis, clinical follow-up, risk factors, Brazil
- MeSH terms
- Humans, Risk Factors, Ultraviolet Rays, Keratosis, Actinic
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