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Studies on Cross-linking of succinic acid with chitosan/collagen
Open accessAbstract
The present study summarizes the cross-linking property of succinic acid with chitosan /collagen. In detail, the chemistry behind the cross-linking and the improvement in mechanical and thermal properties of the cross-linked material were discussed with suitable instruments and bioinformatics tools. The concentration of succinic acid with reference to the chosen polymers was optimized. A 3D scaffold prepared using an optimized concentration of succinic acid (0.2% (w/v)) with chitosan (1.0% (w/v)) and similarly with collagen (0.5% (w/v)), was subjected to surface morphology, FT-IR analysis, tensile strength assessment, thermal stability and biocompatibility. Results revealed, cross-linking with succinic acid impart appreciable mechanical strength to the scaffold material. In silico analysis suggested the prevalence of non-covalent interactions, which played a crucial role in improving the mechanical and thermal properties of the cross-linked scaffold. The resultant 3D scaffold may find application as wound dressing material, as an implant in clinical applications and as a tissue engineering material.
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“The second mass loss event of Col, with a T onset of 266.0 °C and a T max of 312.0 °C (60 %), corresponds to the decomposition of the macromolecular structure of Col (Figure 4A and B) [53].”
From Montmorillonite-reinforced methacrylated collagen/methacrylated silk fibroin hydrogel-based inks: rheological and physicochemical characterization for bone scaffold applications (2026) · cites this paper as [53]
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Cited by
Sorted by citations
Collagen and its modifications—crucial aspects with concern to its processing and analysis
Rýglová, Š., Braun, M., & Suchý, T. (2017) · Macromolecular Materials and Engineering · doi:10.1002/mame.201600460 · Cited by 106
Antunes, B. S. L., Pedrini, F., Komatsu, D., Asami, J., Dicko, C., & Duek, E. A. R. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.154129
Metadata
- Authors
- Mitra, T., Sailakshmi, G., Gnanamani, A., & Mandal, A. B.
- Affiliations
- Central Leather Research Institute (IN)
- Venue
- Materials Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2013-04-23
- Volume
- 16
- Issue
- 4
- Pages
- 755-765
- ISSN
- 1516-1439 (ISSN-L)
- 1980-5373
- OpenAlex
- W2042567183
- Cited by
- 104
- References
- 2
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 8 · 2017: 13 · 2016: 8 · 2015: 8 · 2014: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Materials Research (publishedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- succinic acid, chitosan, collagen, crosslinking, 3D scaffolds, mechanical properties, thermal stability, biocompatibility, non-covalent interactions, wound dressings, tissue engineering
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