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Cited by 181Bee Products Chemical AnalysisHealthcare and Venom ResearchPlant-Derived Bioactive Compounds

Propolis: A review of its anti-inflammatory and healing actions

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Ramos, A. F. N., Miranda, J. L.·2007·Journal of Venomous Animals and Toxins including Tropical Diseases
DOI 10.1590/s1678-91992007000400002
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Abstract

Tissue healing is an adaptive biological response by which the organism repairs damaged tissue. The initial stage of healing is represented by an acute inflammatory reaction, in which inflammatory cells migrate to damaged tissue and phagocyte debris. At a later stage, fibroblasts and endothelial cells proliferate and generate a scar. The occurrence of inflammatory processes and healing imperfections have been a concern for hundreds of years, especially for individuals with healing difficulties, such as diabetics and carriers of peripheral circulation deficiencies. A wide variety of natural products have been used as anti-inflammatory and healing agents, with propolis being a remarkable option. Propolis has been used in popular medicine for a very long time; however, it is not a drug intended for all diseases. Currently, the determination of quality standards of propolis-containing products is a major problem due to their varying pharmacological activities and chemical compositions. The aim of this review is to discuss the use of propolis with emphasis on its anti-inflammatory and healing properties.

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  • The antibacterial activity of propolis is attributed to the synergism of phenolic acids and flavonoids, which inhibit nucleic acid synthesis and depolarize the cytoplasmic membrane, leading to bacterial death.

    “The antibacterial activity of propolis has been attributed to the synergism of the phenolic acids and flavonoids in its chemical composition; these molecules inhibit the nucleic acid synthesis and depolarize the cytoplasmic membrane, which leads to bacterial death [18,40,43,44].”

    From Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis (2023) · cites this paper as [44]

    The passage labeled Abstract reports that propolis has in vitro antibacterial activity arising from synergy among its compounds, mainly the flavonoids pinocembrin and galangin. It does not identify phenolic acids as partners in that antibacterial synergy or say that the compounds inhibit bacterial nucleic acid synthesis or depolarize the cytoplasmic membrane. (LLM, conf=0.88)

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Research works printed but not linked: 48

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Cited by

Sorted by citations

Authors
Ramos, A. F. N., & Miranda, J. L.
Affiliations
Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR)
ORCID
Miranda, J. L.
Venue
Journal of Venomous Animals and Toxins including Tropical Diseases
Publisher
FapUNIFESP (SciELO)
Published
2007
Volume
13
Issue
4
Pages
697-710
ISSN
  • 1678-9180 (ISSN-L)
  • 1678-9199
DOI
10.1590/s1678-91992007000400002
OpenAlex
W2002095229
Cited by
181
References
0
Citations by year
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FWCI
3.45
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • The Journal of venomous animals and toxins including tropical diseases (publishedVersion, cc-by-nc)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
  • Health Sciences › Medicine › Pharmacology › Healthcare and Venom Research
  • Physical Sciences › Chemistry › Organic Chemistry › Plant-Derived Bioactive Compounds
Keywords
propolis, anti-inflammatory activity, tissue repair, wound healing, acute inflammation, diabetic wounds, natural products

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