Effectiveness of home pharmaceutical interventions in metabolic syndrome: a randomized controlled trial
Open accessAbstract
Metabolic syndrome (MetS) is a group of different risk factors that raises the chances of develop several health problems such, as cardiovascular disease and diabetes. There are few cases in literature of studies that specifically address the use of pharmaceutical care in MetS. The aim of study was to evaluate the effectiveness of home pharmaceutical interventions in patients with this syndrome. The randomized clinical trial was conducted in subjects with diagnosis of MetS treated in a basic unit of health from Cuité, Paraíba. The patients were randomized in a 1:1 ratio to two groups: intervention (IG) and control (CG). The IG received monthly individual pharmaceutical interventions, while the CG did not. The effectiveness of the intervention protocol was measured after six months, comparing the hemodynamic values, anthropometric, biochemistry, cardiovascular risk, medication adherence, drug related problems (DRP) and quality of life. The sample consisted of 63 individuals (33 IG and 30 CG) and older than 60 years. The majority of pharmaceutical interventions were educational and/or behavioral. In the intervention group, significant differences were observed in the parameters systolic and diastolic blood pressure, triglycerides, medication adherence and DRP. The pharmaceutical interventions at home were effective in improving medication adherence, decreasing DRPs and helping to control components of the metabolic syndrome.
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Among studies reporting health outcomes, variability in standardisation of health outcomes and scoring interpretation, including instances of scoring in the opposite direction, precluded a meta-analysis of health outcomes and adverse effects.
“Among studies reporting health outcomes, variability in standardisation of health outcomes and scoring interpretation, including instances of scoring in the opposite direction, precluded a meta-analysis of health outcomes49,53 and adverse effects.39,40,43,52”
From Interventions to improve adherence to lipid-lowering drugs: a systematic review and meta-analysis (2025) · cites this paper as [49]
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Pharmacist Interventions to Improve Cardiovascular Disease Risk Factors in Diabetes
Santschi, V., Chiolero, A., Paradis, G., Colosimo, A. L., & Burnand, B. (2012) · Diabetes Care · doi:10.2337/dc12-0369 · Cited by 145 · see citing works
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Interventions to improve adherence to lipid-lowering drugs: a systematic review and meta-analysis
Yow, D. K. W., Ang, W. J., Yap, H. J., Ito, S., Liu, J., Ko, J., Tan, D. S.-Y., Lorenzatti, A., & Ang, C.-S. (2025) · eClinicalMedicine · doi:10.1016/j.eclinm.2025.103270 · Cited by 5 · see citing works
- Authors
- Azevedo, M. D. G. B. D., Pedrosa, R. S., Aoqui, C. M., Martins, R. R., & Nagashima Junior, T.
- Affiliations
- Universidade Estadual da Paraíba (BR)
- Universidade Federal de Campina Grande (BR)
- Universidade Federal do Rio Grande do Norte (BR)
- Federal University of Campina Grande, Brazil
- Venue
- Brazilian Journal of Pharmaceutical Sciences
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2017
- Volume
- 53
- Issue
- 2
- ISSN
- 1984-8250 (ISSN-L)
- OpenAlex
- W2646412555
- Cited by
- 13
- References
- 2
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2014: 1
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Brazilian Journal of Pharmaceutical Sciences (publishedVersion, cc-by)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Keywords
- metabolic syndrome, pharmaceutical care, medication adherence, drug-related problems, blood pressure control, triglycerides, cardiovascular risk, quality of life, older adults, primary care
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