The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dose‐Related Effects of Methadone on QT Prolongation in a Series of Patients with Torsade de Pointes
Abstract
Study Objective. To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone‐treated patients who developed torsade de pointes. Design. Retrospective case series analysis. Setting. Outpatient pain management center and methadone maintenance treatment programs. Patients. Seventeen patients who developed torsade de pointes while receiving very high daily doses of methadone. Measurements and Main Results. The QTc intervals were calculated for each patient. The relationship between daily methadone dose and QTc interval was assessed and adjusted for clinical characteristics that may have independently prolonged cardiac repolarization. The mean QTc interval was 615 ± 77 msec. Multiple linear regression indicated that only the daily methadone dose was predictive of the QTc interval (r = +0.51, p=0.03). All other variables examined, such as age, sex, presence of hypokalemia or structural heart disease, and presence of QT‐prolonging drugs, were not predictive of the QTc interval (minimum p=0.28). Conclusion. In this series, the daily methadone dose correlated positively with the QTc interval. This finding supports the possibility that methadone contributed to the development of arrhythmia.
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Woosley, R. L. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03500120070028 · Cited by 646
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Effect of methadone maintenance treatment on heroin craving, a literature review
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QT Interval Screening in Methadone Maintenance Treatment: Report of a SAMHSA Expert Panel
Martin, J. A., Campbell, A., Killip, T., Kotz, M., Krantz, M. J., Kreek, M. J., McCarroll, B. A., Mehta, D., Payte, J. T., Stimmel, B., et al. (2011) · Journal of Addictive Diseases · doi:10.1080/10550887.2011.610710 · Cited by 87
“68 further analyzed the same data and determined that methadone use was the only variable predictive of QT interval increases and that the increases were dose-dependent.”
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Metadata
- Authors
- Krantz, M. J., Kutinsky, I. B., Robertson, A. D., & Mehler, P. S.
- Venue
- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
- Publisher
- Wiley
- Published
- 2003-06
- Volume
- 23
- Issue
- 6
- Pages
- 802-805
- ISSN
- 0277-0008 (ISSN-L)
- 1875-9114
- OpenAlex
- W2064639600
- Cited by
- 232
- References
- 1
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Dose‐Related Effects of Methadone on QT Prolongation in a Series of Patients with Torsade de Pointes. https://app.cochat.ai/papers/10.1592/phco.23.6.802.32186
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- Krantz, M. J., Kutinsky, I. B., Robertson, A. D., & Mehler, P. S. (2003). Dose‐Related Effects of Methadone on QT Prolongation in a Series of Patients with Torsade de Pointes. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. https://doi.org/10.1592/phco.23.6.802.32186
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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