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Glioma Tropic Neural Stem Cells Consist of Astrocytic Precursors and Their Migratory Capacity Is Mediated by CXCR4
Open accessAbstract
Malignant gliomas spawn disseminated microsatellites, which are largely refractory to currently employed therapies, resulting in eventual tumor recurrence and death. The use of tumor-tropic neural stem cells (NSCs) as delivery vehicles for therapeutic gene products represents an attractive strategy specifically focused at treating these residual neoplastic foci. We wished to elucidate the biological cues governing NSC tropism for glioma. In this context, we describe that tumor-tropic NSCs comprise largely of astrocytic progenitors expressing chemokine receptor 4 (CXCR4). Blocking of CXCR4 significantly inhibits NSC migration toward the tumor. These findings define specific characteristics associated with the cell populations within transplanted NSCs that demonstrate glioma-tracking behavior.
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Lazarini, F., Tham, T. N., Casanova, P., Arenzana‐Seisdedos, F., & Dubois‐Dalcq, M. (2003) · Glia · doi:10.1002/glia.10139 · Cited by 280
Cited by
Vescovi, A. L., Galli, R., & Reynolds, B. A. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1889 · Cited by 990
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
Soeda, A., Park, M., Lee, D., Mintz, A., Androutsellis-Theotokis, A., McKay, R. D., Engh, J., Iwama, T., Kunisada, T., Kassam, A. B., et al. (2009) · Oncogene · doi:10.1038/onc.2009.252 · Cited by 656
Hattermann, K., Held-Feindt, J., Lucius, R., Müerköster, S. S., Penfold, M. E. T., Schall, T. J., & Mentlein, R. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3642 · Cited by 295
Gene therapy: can neural stem cells deliver?
Müller, F.-J., Snyder, E. Y., & Loring, J. F. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1829 · Cited by 274
Mesenchymal Stem Cells Effectively Deliver an Oncolytic Adenovirus to Intracranial Glioma
Sonabend, A. M., Ulasov, I. V., Tyler, M. A., Rivera, A. A., Mathis, J. M., & Lesniak, M. S. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0758 · Cited by 254
Metadata
- Authors
- Ehtesham, M., Yuan, X., Kabos, P., Chung, N. H. C., Liu, G., Akasaki, Y., Black, K. L., & Yu, J. S.
- Venue
- Neoplasia
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 6
- Issue
- 3
- Pages
- 287-293
- ISSN
- 1476-5586 (ISSN-L)
- OpenAlex
- W4233423789
- Cited by
- 160
- References
- 1
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Glioma Tropic Neural Stem Cells Consist of Astrocytic Precursors and Their Migratory Capacity Is Mediated by CXCR4. https://app.cochat.ai/papers/10.1593/neo.03427
- The paper
- Ehtesham, M., Yuan, X., Kabos, P., Chung, N. H. C., Liu, G., Akasaki, Y., Black, K. L., & Yu, J. S. (2004). Glioma Tropic Neural Stem Cells Consist of Astrocytic Precursors and Their Migratory Capacity Is Mediated by CXCR4. Neoplasia. https://doi.org/10.1593/neo.03427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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