The DOI matches its Crossref record.
Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes: SIGNIFICANCE FOR EFFECTIVENESS AS ANTICANCER DRUGS
Open accessAbstract
Metal coordination compounds with ‘slow’metal-ligand exchange rates, comparable to those of cell division processes, often appear to be highly active in killing cancer cell lines. This is particularly marked in platinum and ruthenium complexes. Classical examples such as cisplatin, as well as very recent examples from the author’s and other work, will be discussed in detail, and in the context of the current knowledge of the mechanism of antitumour action. It is shown that even though much is known about the molecular mechanism of action of cisplatin, many challenging questions are left for future research. For the ruthenium anticancer drugs molecular mechanistic studies are only at the beginning. Mechanistic studies on both platinum and ruthenium compounds have, however, opened many new avenues of research that may lead to the design of completely new drugs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Zhou, W., Saran, R., & Liu, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00063 · Cited by 931
Electro- and Solar-Driven Fuel Synthesis with First Row Transition Metal Complexes
Dalle, K. E., Warnan, J., Leung, J. J., Reuillard, B., Karmel, I. S., & Reisner, E. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00392 · Cited by 912
Recent developments in ruthenium anticancer drugs
Levina, A., Mitra, A., & Lay, P. A. (2009) · Metallomics · doi:10.1039/b904071d · Cited by 592
Min, Y., Li, J., Liu, F., Yeow, E. K. L., & Xing, B. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308834 · Cited by 309
Modulation of the Aβ peptide aggregation pathway by KP1019 limits Aβ-associated neurotoxicity
Jones, M. R., Mu, C., Wang, M. C. P., Webb, M. I., Walsby, C. J., & Storr, T. (2015) · Metallomics · doi:10.1039/c4mt00252k · Cited by 50
Metadata
- Authors
- Reedijk, B. J.
- Venue
- Platinum Metals Review
- Publisher
- Johnson Matthey Plc
- Published
- 2008-01-01
- Volume
- 52
- Issue
- 1
- Pages
- 2-11
- ISSN
- 0032-1400 (ISSN-L)
- OpenAlex
- W1966575041
- Cited by
- 312
- References
- 0
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes: SIGNIFICANCE FOR EFFECTIVENESS AS ANTICANCER DRUGS. https://app.cochat.ai/papers/10.1595/147106708x255987
- The paper
- Reedijk, B. J. (2008). Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes: SIGNIFICANCE FOR EFFECTIVENESS AS ANTICANCER DRUGS. Platinum Metals Review. https://doi.org/10.1595/147106708x255987
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
