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The Role of Cytokines in Gestation
Abstract
Lymphohemopoietic cytokines are now recognized to be central participants in the cellular communication events underlying the complex and dynamic remodeling processes required to accommodate the semiallogeneic conceptus during mammalian reproduction. Cytokines are identified to be particular importance in mediating communications between the conceptus and maternal cells, particularly the uterine epithelium and infiltrating leukocytes, both prior to implantation and as the placenta develops. In this review we summarize recent experimental data concerning the synthesis of various cytokines in uterine and conceptus-derived tissues and highlight current hypotheses for their roles in establishing and maintaining successful pregnancy. It is concluded that complex and finely balanced cytokine networks underpin precise regulatory mechanisms controlling the rate and degree of conceptus development and invasion into maternal tissues.
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Citations
Cited by
Neonatal cytokines and coagulation factors in children with cerebral palsy
Nelson, K. B., Dambrosia, J. M., Grether, J. K., & Phillips, T. M. (1998) · Annals of Neurology · doi:10.1002/ana.410440413 · Cited by 549
Pre-implantation endometrial leukocytes in women with recurrent miscarriage
Quenby, S., Bates, M., Doig, T., Brewster, J., Lewis-Jones, D. I., Johnson, P. M., & Vince, G. (1999) · Human Reproduction · doi:10.1093/humrep/14.9.2386 · Cited by 301
Fried, M., Muga, R. O., Misore, A. O., & Duffy, P. E. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.5.2523 · Cited by 262
Tosun, M., Celik, H., Avci, B., Yavuz, E., Alper, T., & Malatyalioğlu, E. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767051003774942 · Cited by 185
Rogerson, S. J., Brown, H. C., Pollina, E., Abrams, E. T., Tadesse, E., Lema, V. M., & Molyneux, M. E. (2003) · Infection and Immunity · doi:10.1128/iai.71.1.267-270.2003 · Cited by 163
Metadata
- Authors
- Robertson, S. A., Seamark, R. F., Guilbert, L. J., & Wegmann, T. G.
- Venue
- Critical Reviews™ in Immunology
- Publisher
- Begell House
- Published
- 1994
- Volume
- 14
- Issue
- 3-4
- Pages
- 239-292
- ISSN
- 0197-3355 (ISSN-L)
- 2162-6472
- OpenAlex
- W2092679069
- Cited by
- 252
- References
- 0
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Robertson, S. A., Seamark, R. F., Guilbert, L. J., & Wegmann, T. G. (1994). The Role of Cytokines in Gestation. Critical Reviews™ in Immunology. https://doi.org/10.1615/critrevimmunol.v14.i3-4.30
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.