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The Role of Cytokines in Gestation

Robertson, Sarah A., Seamark, Robert F., Guilbert, Larry J., Wegmann, Thomas G.·1994·Critical Reviews™ in Immunology

Abstract

Lymphohemopoietic cytokines are now recognized to be central participants in the cellular communication events underlying the complex and dynamic remodeling processes required to accommodate the semiallogeneic conceptus during mammalian reproduction. Cytokines are identified to be particular importance in mediating communications between the conceptus and maternal cells, particularly the uterine epithelium and infiltrating leukocytes, both prior to implantation and as the placenta develops. In this review we summarize recent experimental data concerning the synthesis of various cytokines in uterine and conceptus-derived tissues and highlight current hypotheses for their roles in establishing and maintaining successful pregnancy. It is concluded that complex and finely balanced cytokine networks underpin precise regulatory mechanisms controlling the rate and degree of conceptus development and invasion into maternal tissues.

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Metadata

Authors
Robertson, S. A., Seamark, R. F., Guilbert, L. J., & Wegmann, T. G.
Venue
Critical Reviews™ in Immunology
Publisher
Begell House
Published
1994
Volume
14
Issue
3-4
Pages
239-292
ISSN
  • 0197-3355 (ISSN-L)
  • 2162-6472
OpenAlex
W2092679069
Cited by
252
References
0
FWCI
4.59
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Role of Cytokines in Gestation. https://app.cochat.ai/papers/10.1615/critrevimmunol.v14.i3-4.30
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Robertson, S. A., Seamark, R. F., Guilbert, L. J., & Wegmann, T. G. (1994). The Role of Cytokines in Gestation. Critical Reviews™ in Immunology. https://doi.org/10.1615/critrevimmunol.v14.i3-4.30

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.