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Cited by 81Reproductive tract infections researchMicrobial infections and disease researchImmune Response and Inflammation

Chlamydial Infection of Immune Cells: Altered Function and Implications for Disease

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Beagley, Kenneth, Huston, Wilhelmina M., Hansbro, Philip M., Timms, Peter·2009·Critical Reviews™ in Immunology
DOI 10.1615/critrevimmunol.v29.i4.10
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Abstract

Chlamydia trachomatis is an obligate intracellular bacterial pathogen that infects the genital and ocular mucosa of humans, causing infections that can lead to pelvic inflammatory disease, infertility, and blinding trachoma. C. pneumoniae is a respiratory pathogen that is the cause of 12-15% of community-acquired pneumonia. Both chlamydial species were believed to be restricted to the epithelia of the genital, ocular, and respiratory mucosa; however, increasing evidence suggests that both these pathogens can be isolated from peripheral blood of both healthy individuals and patients with inflammatory conditions such as coronary artery disease and asthma. Chlamydia can also be isolated from brain tissues of patients with degenerative neurological disorders such as Alzheimer's disease and multiple sclerosis, and also from certain lymphomas. An increasing number of in vitro studies suggest that some chlamydial species can infect immune cells, at least at low levels. These infections may alter immune cell function in a way that promotes chlamydial persistence in the host and contributes to the progression of several chronic inflammatory diseases. In this paper, we review the evidence for the growth of Chlamydia in immune cells, particularly monocytes/macrophages and dendritic cells, and describe how infection may affect the function of these cells.

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Authors
Beagley, K., Huston, W. M., Hansbro, P. M., & Timms, P.
Affiliations
  • Queensland University of Technology (AU)
  • University of Technology Sydney (AU)
ORCID
Venue
Critical Reviews™ in Immunology
Publisher
Begell House
Published
2009
Volume
29
Issue
4
Pages
275-305
ISSN
  • 0197-3355 (ISSN-L)
  • 2162-6472
DOI
10.1615/critrevimmunol.v29.i4.10
OpenAlex
W1522243508
Cited by
81
References
0
Citations by year
2025: 1 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 12 · 2012: 9
FWCI
5.49
Type
journal article
Language
en
Open access
Locations
  • Critical Reviews in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • QUT ePrints (Queensland University of Technology) (submittedVersion)
  • USC Research Bank (University of the Sunshine Coast) (submittedVersion)
  • Institute of Health and Biomedical Innovation
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
Chlamydia trachomatis, Chlamydia pneumoniae, monocytes, macrophages, dendritic cells, chlamydial persistence, chronic inflammation, Alzheimer's disease, multiple sclerosis, lymphoma, pelvic inflammatory disease, trachoma, community-acquired pneumonia
MeSH terms
Animals, Chlamydia, Chlamydia Infections, Dendritic Cells, Biological Evolution, Humans, Inflammation, Macrophages, Monocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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