The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Mesenchymal Stem Cells in the Wharton's Jelly of the Human Umbilical Cord
Open accessAbstract
The Wharton's jelly of the umbilical cord contains mucoid connective tissue and fibroblast-like cells. Using flow cytometric analysis, we found that mesenchymal cells isolated from the umbilical cord express matrix receptors (CD44, CD105) and integrin markers (CD29, CD51) but not hematopoietic lineage markers (CD34, CD45). Interestingly, these cells also express significant amounts of mesenchymal stem cell markers (SH2, SH3). We therefore investigated the potential of these cells to differentiate into cardiomyocytes by treating them with 5-azacytidine or by culturing them in cardiomyocyte-conditioned medium and found that both sets of conditions resulted in the expression of cardiomyocyte markers, namely N-cadherin and cardiac troponin I. We also showed that these cells have multilineage potential and that, under suitable culture conditions, are able to differentiate into cells of the adipogenic and osteogenic lineages. These findings may have a significant impact on studies of early human cardiac differentiation, functional genomics, pharmacological testing, cell therapy, and tissue engineering by helping to eliminate worrying ethical and technical issues.
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Cites
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Cited by
Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
Vizoso, F., Eiro, N., Cid, S., Schneider, J., & Perez-Fernandez, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091852 · Cited by 1,363
Mesenchymal stem cells and immunomodulation: current status and future prospects
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Mesenchymal stromal cells: new directions
Keating, A. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.015 · Cited by 778
Metadata
- Authors
- Wang, H., Hung, S., Peng, S., Huang, C., Wei, H., Guo, Y., Fu, Y., Lai, M., & Chen, C.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-12
- Volume
- 22
- Issue
- 7
- Pages
- 1330-1337
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1996789930
- Cited by
- 1,378
- References
- 29
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, H., Hung, S., Peng, S., Huang, C., Wei, H., Guo, Y., Fu, Y., Lai, M., & Chen, C. (2004). Mesenchymal Stem Cells in the Wharton's Jelly of the Human Umbilical Cord. STEM CELLS. https://doi.org/10.1634/stemcells.2004-0013
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