The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Marrow Stromal Cells Transplanted to the Adult Brain Are Rejected by an Inflammatory Response and Transfer Donor Labels to Host Neurons and Glia
Abstract
Abstract The remarkable plasticity of marrow stromal cells (MSCs) after transplantation to models of neurological disease and injury has been described. In this report, we investigated the plasticity and long-term survival of MSCs transplanted into the normal brain. MSCs were isolated from green fluorescent protein (GFP) transgenic rats and double-labeled with 5-bromo-2-deoxyuridine (BrdU) and bis benzamide (BBZ) prior to transplantation into the adult hippocampus or striatum. Surgery elicited an immediate inflammatory response. MSC grafts were massively infiltrated by ED1-positive microglia/macrophages and surrounded by a marked astrogliosis. By 14 days, graft volume had retracted and GFP immunoreactivity was absent, indicating complete donor rejection. Consequently, MSCs did not exhibit plasticity formerly identified in other studies. However, BrdU- and BBZ-labeled cells were detected up to 12 weeks. Control transplants of nonviable MSCs demonstrated the transfer of donor labels to host cells. Unexpectedly, BrdU labeling was colocalized to host phagocytes, astrocytes, and neurons in both regions. Our results indicate that MSCs transplanted to the intact adult brain are rejected by an inflammatory response. Moreover, use of the traditional cell labels BrdU and BBZ may provide a misleading index of donor survival and differentiation after transplantation.
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Cites
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Cited by
Fischer, U. M., Harting, M. T., Jimenez, F., Monzon-Posadas, W. O., Xue, H., Savitz, S. I., Laine, G. A., & Cox, C. S. (2009) · Stem Cells and Development · doi:10.1089/scd.2008.0253 · Cited by 1,292
In Search of the In Vivo Identity of Mesenchymal Stem Cells
da Silva Meirelles, L., Caplan, A. I., & Nardi, N. B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1122 · Cited by 1,077
Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury
Parr, A. M., Tator, C. H., & Keating, A. (2007) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705757 · Cited by 447
The mouse excisional wound splinting model, including applications for stem cell transplantation
Wang, X., Ge, J., Tredget, E. E., & Wu, Y. (2013) · Nature Protocols · doi:10.1038/nprot.2013.002 · Cited by 440
Intranasal delivery of cells to the brain
Danielyan, L., Schäfer, R., von Ameln-Mayerhofer, A., Buadze, M., Geisler, J., Klopfer, T., Burkhardt, U., Proksch, B., Verleysdonk, S., Ayturan, M., et al. (2009) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2009.02.001 · Cited by 355
Metadata
- Authors
- Coyne, T. M., Marcus, A. J., Woodbury, D., & Black, I. B.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11
- Volume
- 24
- Issue
- 11
- Pages
- 2483-2492
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1970313665
- Cited by
- 238
- References
- 4
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Coyne, T. M., Marcus, A. J., Woodbury, D., & Black, I. B. (2006). Marrow Stromal Cells Transplanted to the Adult Brain Are Rejected by an Inflammatory Response and Transfer Donor Labels to Host Neurons and Glia. STEM CELLS. https://doi.org/10.1634/stemcells.2006-0174
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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