The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Human Dental Pulp Stem Cells Improve Left Ventricular Function, Induce Angiogenesis, and Reduce Infarct Size in Rats with Acute Myocardial Infarction
Abstract
Human dental pulp contains precursor cells termed dental pulp stem cells (DPSC) that show self-renewal and multilineage differentiation and also secrete multiple proangiogenic and antiapoptotic factors. To examine whether these cells could have therapeutic potential in the repair of myocardial infarction (MI), DPSC were infected with a retrovirus encoding the green fluorescent protein (GFP) and expanded ex vivo. Seven days after induction of myocardial infarction by coronary artery ligation, 1.5 × 106 GFP-DPSC were injected intramyocardially in nude rats. At 4 weeks, cell-treated animals showed an improvement in cardiac function, observed by percentage changes in anterior wall thickening left ventricular fractional area change, in parallel with a reduction in infarct size. No histologic evidence was seen of GFP+ endothelial cells, smooth muscle cells, or cardiac muscle cells within the infarct. However, angiogenesis was increased relative to control-treated animals. Taken together, these data suggest that DPSC could provide a novel alternative cell population for cardiac repair, at least in the setting of acute MI. Disclosure of potential conflicts of interest is found at the end of this article.
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Cites
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P., De Ugarte, D. A., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,664
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
Gronthos, S., Mankani, M., Brahim, J., Robey, P. G., & Shi, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240309797 · Cited by 4,570
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Kern, S., Eichler, H., Stoeve, J., Klüter, H., & Bieback, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0342 · Cited by 3,370
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Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction
Miyahara, Y., Nagaya, N., Kataoka, M., Yanagawa, B., Tanaka, K., Hao, H., Ishino, K., Ishida, H., Shimizu, T., Kangawa, K., et al. (2006) · Nature Medicine · doi:10.1038/nm1391 · Cited by 1,193
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Metadata
- Authors
- Gandia, C., Armiñan, A., García-Verdugo, J. M., Lledó, E., Ruiz, A., Miñana, M. D., Sanchez-Torrijos, J., Payá, R., Mirabet, V., Carbonell-Uberos, F., Llop, M., Montero, J. A., & Sepúlveda, P.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12-13
- Volume
- 26
- Issue
- 3
- Pages
- 638-645
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2041308307
- Cited by
- 406
- References
- 30
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gandia, C., Armiñan, A., García-Verdugo, J. M., Lledó, E., Ruiz, A., Miñana, M. D., Sanchez-Torrijos, J., Payá, R., Mirabet, V., Carbonell-Uberos, F., Llop, M., Montero, J. A., & Sepúlveda, P. (2008). Human Dental Pulp Stem Cells Improve Left Ventricular Function, Induce Angiogenesis, and Reduce Infarct Size in Rats with Acute Myocardial Infarction. Stem Cells. https://doi.org/10.1634/stemcells.2007-0484
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