The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enumeration of Neural Stem and Progenitor Cells in the Neural Colony-Forming Cell Assay
Abstract
Advancement in our understanding of the biology of adult stem cells and their therapeutic potential relies heavily on meaningful functional assays that can identify and measure stem cell activity in vivo and in vitro. In the mammalian nervous system, neural stem cells (NSCs) are often studied using a culture system referred to as the neurosphere assay. We previously challenged a central tenet of this assay, that all neurospheres are derived from a NSC, and provided evidence that it overestimates NSC frequency, rendering it inappropriate for quantitation of NSC frequency in relation to NSC regulation. Here we report the development and validation of the neural colony-forming cell assay (NCFCA), which discriminates stem from progenitor cells on the basis of their proliferative potential. We anticipate that the NCFCA will provide additional clarity in discerning the regulation of NSCs, thereby facilitating further advances in the promising application of NSCs for therapeutic use. Disclosure of potential conflicts of interest is found at the end of this article.
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Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
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Cited by
Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
Chong, J. J. H., Chandrakanthan, V., Xaymardan, M., Asli, N. S., Li, J., Ahmed, I., Heffernan, C., Menon, M. K., Scarlett, C. J., Rashidianfar, A., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.10.002 · Cited by 389
Bar, E. E., Lin, A., Mahairaki, V., Matsui, W., & Eberhart, C. G. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.091021 · Cited by 373
Adult neural stem cells in the mammalian central nervous system
Ma, D. K., Bonaguidi, M. A., Ming, G.-L., & Song, H. (2009) · Cell Research · doi:10.1038/cr.2009.56 · Cited by 329
Neural stem cell systems: physiological players or in vitro entities?
Conti, L., & Cattaneo, E. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2761 · Cited by 320
Blackmore, D. G., Golmohammadi, M. G., Large, B., Waters, M. J., & Rietze, R. L. (2009) · Stem Cells · doi:10.1002/stem.120 · Cited by 119
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Metadata
- Authors
- Louis, S. A., Rietze, R. L., Deleyrolle, L., Wagey, R. E., Thomas, T. E., Eaves, A. C., & Reynolds, B. A.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-24
- Volume
- 26
- Issue
- 4
- Pages
- 988-996
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2048784291
- Cited by
- 196
- References
- 1
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Louis, S. A., Rietze, R. L., Deleyrolle, L., Wagey, R. E., Thomas, T. E., Eaves, A. C., & Reynolds, B. A. (2008). Enumeration of Neural Stem and Progenitor Cells in the Neural Colony-Forming Cell Assay. Stem Cells. https://doi.org/10.1634/stemcells.2007-0867
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