The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
SOX2 Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity
Abstract
Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self-renewal of several stem cells, in particular neural stem cells. To investigate its role in the aberrant growth of glioblastoma, we silenced SOX2 in freshly derived glioblastoma tumor-initiating cells (TICs). Our results indicate that SOX2 silenced glioblastoma TICs, despite the many mutations they have accumulated, stop proliferating and lose tumorigenicity in immunodeficient mice. SOX2 is then also fundamental for maintenance of the self-renewal capacity of neural stem cells when they have acquired cancer properties. SOX2, or its immediate downstream effectors, would then be an ideal target for glioblastoma therapy.
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Cites
The 2007 WHO Classification of Tumours of the Central Nervous System
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Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma
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Cancerous stem cells can arise from pediatric brain tumors
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SOX2 Functions to Maintain Neural Progenitor Identity
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An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
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Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
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Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain
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Cited by
Targeting cancer stem cell pathways for cancer therapy
Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0110-5 · Cited by 1,906
Cancer stem cells in glioblastoma
Lathia, J. D., Mack, S. C., Mulkearns-Hubert, E. E., Valentim, C. L. L., & Rich, J. N. (2015) · Genes & Development · doi:10.1101/gad.261982.115 · Cited by 1,520
Heddleston, J. M., Li, Z., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9701 · Cited by 813
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
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Chen, W.-J., Ho, C.-C., Chang, Y.-L., Chen, H.-Y., Lin, C.-A., Ling, T.-Y., Yu, S.-L., Yuan, S.-S., Louisa Chen, Y.-J., Lin, C.-Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms4472 · Cited by 422
Metadata
- Authors
- Gangemi, R. M. R., Griffero, F., Marubbi, D., Perera, M., Capra, M. C., Malatesta, P., Ravetti, G. L., Zona, G. L., Daga, A., & Corte, G.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-01
- Volume
- 27
- Issue
- 1
- Pages
- 40-48
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1999553354
- Cited by
- 578
- References
- 24
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Gangemi, R. M. R., Griffero, F., Marubbi, D., Perera, M., Capra, M. C., Malatesta, P., Ravetti, G. L., Zona, G. L., Daga, A., & Corte, G. (2009). SOX2 Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity. Stem Cells. https://doi.org/10.1634/stemcells.2008-0493
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
