The DOI matches its Crossref record.
Human Embryonic Stem Cell Lines Derived from Discarded Embryos
Abstract
Human pluripotent embryonic stem (ES) cells have important potential in regenerative medicine and as models for human preimplantation development; however, debate continues over whether embryos should be destroyed to produce human ES cells. We have derived four ES cell lines on mouse embryonic fibroblast cells in medium supplemented with basic fibroblast growth factor, human recombinant leukemia inhibitory factor, and fetal bovine serum. The source of these cell lines was poor-quality embryos that in the course of routine clinical practice would have been discarded. After continuous proliferation in vitro for more than 12 months, these ES cell lines maintained their developmental potential to form trophoblast and somatic cells, including cardiac muscle and neuronal tissue.
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Citations
Cited by
Human embryonic stem cell lines derived from single blastomeres
Klimanskaya, I., Chung, Y., Becker, S., Lu, S.-J., & Lanza, R. (2006) · Nature · doi:10.1038/nature05142 · Cited by 522
Characterization and culture of human embryonic stem cells
Hoffman, L. M., & Carpenter, M. K. (2005) · Nature Biotechnology · doi:10.1038/nbt1102 · Cited by 465
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons
Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., Baru, V., Lou, Y., Freyzon, Y., Cho, S., et al. (2013) · Science · doi:10.1126/science.1245296 · Cited by 441
Self-citationBurridge, P. W., Anderson, D., Priddle, H., Barbadillo Muñoz, M. D., Chamberlain, S., Allegrucci, C., Young, L. E., & Denning, C. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0598 · Cited by 301
HLA engineering of human pluripotent stem cells
Riolobos, L., Hirata, R. K., Turtle, C. J., Wang, P.-R., Gornalusse, G. G., Zavajlevski, M., Riddell, S. R., & Russell, D. W. (2013) · Molecular Therapy · doi:10.1038/mt.2013.59 · Cited by 253
Metadata
- Authors
- Mitalipova, M., Calhoun, J., Shin, S., Wininger, D., Schulz, T., Noggle, S., Venable, A., Lyons, I., Robins, A., & Stice, S.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09-01
- Volume
- 21
- Issue
- 5
- Pages
- 521-526
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1989780518
- Cited by
- 234
- References
- 0
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mitalipova, M., Calhoun, J., Shin, S., Wininger, D., Schulz, T., Noggle, S., Venable, A., Lyons, I., Robins, A., & Stice, S. (2003). Human Embryonic Stem Cell Lines Derived from Discarded Embryos. Stem Cells. https://doi.org/10.1634/stemcells.21-5-521
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