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Understanding and Managing Methotrexate Nephrotoxicity
Abstract
Learning Objectives: After completing this course, the reader will be able to: Discuss the pharmacology of methotrexate.Describe the current incidence and presentation of high-dose methotrexate-induced renal dysfunction.Discuss conventional and investigational treatment approaches to high-dose methotrexate-induced renal dysfunction. Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.com
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Citations
Cited by
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Drug-induced kidney stones and crystalline nephropathy: pathophysiology, prevention and treatment
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Evaluation of incidence and risk factors for high-dose methotrexate-induced nephrotoxicity
Wiczer, T., Dotson, E., Tuten, A., Phillips, G., & Maddocks, K. (2016) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155215594417 · Cited by 112
Invasive placentation and uterus preserving treatment modalities: a systematic review
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Detection of Hepatotoxicity Potential with Metabolite Profiling (Metabolomics) of Rat Plasma
Mattes, W., Davis, K., Fabian, E., Greenhaw, J., Herold, M., Looser, R., Mellert, W., Groeters, S., Marxfeld, H., Moeller, N., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.07.021 · Cited by 65
Metadata
- Authors
- Widemann, B. C., & Adamson, P. C.
- Venue
- The Oncologist
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-01
- Volume
- 11
- Issue
- 6
- Pages
- 694-703
- ISSN
- 1083-7159 (ISSN-L)
- 1549-490X
- OpenAlex
- W2124815378
- Cited by
- 730
- References
- 0
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Understanding and Managing Methotrexate Nephrotoxicity. https://app.cochat.ai/papers/10.1634/theoncologist.11-6-694
- The paper
- Widemann, B. C., & Adamson, P. C. (2006). Understanding and Managing Methotrexate Nephrotoxicity. The Oncologist. https://doi.org/10.1634/theoncologist.11-6-694
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
