The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Chordoma: The Nonsarcoma Primary Bone Tumor
Open accessAbstract
Chordomas are rare, slowly growing, locally aggressive neoplasms of bone that arise from embryonic remnants of the notochord. These tumors typically occur in the axial skeleton and have a proclivity for the spheno-occipital region of the skull base and sacral regions. In adults, 50% of chordomas involve the sacrococcygeal region, 35% occur at the base of the skull near the spheno-occipital area, and 15% are found in the vertebral column. Craniocervical chordomas most often involve the dorsum sella, clivus, and nasopharynx. Chordomas are divided into conventional, chondroid, and dedifferentiated types. Conventional chordomas are the most common. They are characterized by the absence of cartilaginous or additional mesenchymal components. Chondroid chordomas contain both chordomatous and chondromatous features, and have a predilection for the spheno-occipital region of the skull base. This variant accounts for 5%–15% of all chordomas and up to 33% of cranial chordomas. Dedifferentiation or sarcomatous transformation occurs in 2%–8% of chordomas. This can develop at the onset of the disease or later. Aggressive initial therapy improves overall outcome. Patients who relapse locally have a poor prognosis but both radiation and surgery can be used as salvage therapy. Subtotal resection can result in a stable or improved status in as many as 50% of patients who relapse after primary therapy. Radiation therapy may also salvage some patients with local recurrence. One series reported a 2-year actuarial local control rate of 33% for patients treated with proton beam irradiation.
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Pathology and genetics of tumours of soft tissue and bone
Fletcher, C. D. �., Unni, K. K., & Mertens, F. (2002) · Medical Entomology and Zoology · Cited by 2,073
Chordoma: incidence and survival patterns in the United States, 1973–1995
McMaster, M. L., Goldstein, A. M., Bromley, C. M., Ishibe, N., & Parry, D. M. (2001) · Cancer Causes & Control · doi:10.1023/a:1008947301735 · Cited by 966
Proton radiation therapy for chordomas and chondrosarcomas of the skull base
Hug, E. B., Loredo, L. N., Slater, J. D., Devries, A., Grove, R. I., Schaefer, R. A., Rosenberg, A. E., & Slater, J. M. (1999) · Journal of Neurosurgery · doi:10.3171/jns.1999.91.3.0432 · Cited by 510
Chordoma of the Mobile Spine: Fifty Years of Experience
Boriani, S., Bandiera, S., Biagini, R., Bacchini, P., Boriani, L., Cappuccio, M., Chevalley, F., Gasbarrini, A., Picci, P., & Weinstein, J. N. (2006) · Spine · doi:10.1097/01.brs.0000200038.30869.27 · Cited by 425
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Results of carbon ion radiotherapy in 152 patients
Schulz–Ertner, D., Nikoghosyan, A. V., Thilmann, C., Haberer, T., Jäkel, O., Karger, C. P., Kraft, G., Wannenmacher, M. F., & Debus, J. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2003.09.041 · Cited by 287
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Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors
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Brainstem tolerance to conformal radiotherapy of skull base tumors
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Cited by
Chordoma: current concepts, management, and future directions
Walcott, B. P., Nahed, B. V., Mohyeldin, A., Coumans, J.-V., Kahle, K. T., & Ferreira, M. J. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70337-0 · Cited by 769
DNA methylation-based prognostic subtypes of chordoma tumors in tissue and plasma
Zuccato, J. A., Patil, V., Mansouri, S., Liu, J. C., Nassiri, F., Mamatjan, Y., Chakravarthy, A., Karimi, S., Almeida, J. P., Bernat, A.-L., et al. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noab235 · Cited by 53
Metadata
- Authors
- Chugh, R., Tawbi, H., Lucas, D. R., Biermann, J. S., Schuetze, S. M., & Baker, L. H.
- Venue
- The Oncologist
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-01
- Volume
- 12
- Issue
- 11
- Pages
- 1344-1350
- ISSN
- 1083-7159 (ISSN-L)
- 1549-490X
- OpenAlex
- W2099252068
- Cited by
- 388
- References
- 21
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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