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Mean Inactivation Dose: A Useful Concept for Intercomparison of Human Cell Survival Curves
Abstract
The mean inactivation dose (D) is calculated for published in vitro survival curves obtained from cell lines of both normal and neoplastic human tissues. Cells belonging to different histological categories (melanomas, carcinomas, etc.) are shown to be characterized by distinct values of D which are related to the clinical radiosensitivity of tumors from these categories. Compared to other ways of representing in vitro radiosensitivity, e.g., by the multitarget parameters D0 and n, the parameter D has several specific advantages: (i) D is representative for the whole cell population rather than for a fraction of it; (ii) it minimizes the fluctuations of the survival curves of a given cell line investigated by different authors; (iii) there is low variability of D within each histological category; (iv) significant differences in radiosensitivity between the categories emerge when using D. D appears to be a useful concept for specifying intrinsic radiosensitivity of human cell lines.
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Cited by
Fertil, B., & Malaise, E. P. (1985) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(85)90223-8 · Cited by 481
Self-citationA review of human cell radiosensitivity in vitro
Deschavanne, P. J., & Fertil, B. (1996) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(95)02029-2 · Cited by 295
Self-citationInhibition of mTOR radiosensitizes soft tissue sarcoma and tumor vasculature
Murphy, J. D., Spalding, A. C., Somnay, Y. R., Markwart, S., Ray, M. E., & Hamstra, D. A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1019 · Cited by 44
Metadata
- Authors
- Fertil, B., Dertinger, H., Courdi, A., & Malaise, E. P.
- Venue
- Radiation Research
- Publisher
- Radiation Research Society
- Published
- 2012-08
- Volume
- 178
- Issue
- 2
- Pages
- AV237-AV243
- ISSN
- 0033-7587 (ISSN-L)
- 1938-5404
- OpenAlex
- W2160981368
- Cited by
- 350
- References
- 0
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fertil, B., Dertinger, H., Courdi, A., & Malaise, E. P. (2012). Mean Inactivation Dose: A Useful Concept for Intercomparison of Human Cell Survival Curves. Radiation Research. https://doi.org/10.1667/rrav20.1
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