Radiation-induced hypopituitarism
Open accessAbstract
The hypothalamic–pituitary unit is a particularly radiosensitive region in the central nervous system. As a consequence, hypopituitarism commonly develops after radiation treatments for sellar and parasellar neoplasms, extrasellar brain tumours, head and neck tumours, and following whole body irradiation for systemic malignancies. Increasing tumour-related survival rates provide an expanding population at risk of developing hypopituitarism. In this population, long-term monitoring tailored to the individual risk profile is required to avoid the sequelae of untreated pituitary hormonal deficiencies and resultant decrease in the quality of life. This review analyses the pathogenesis, prevalence and consequences of radiation-induced hypopituitarism (RIH) in diverse subgroups at risk. Also discussed is the impact of modern radiotherapy techniques in the prevalence of RIH, the spectrum of endocrine disorders and radiation-induced brain conditions that also occur in patients with RIH.
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References 330 · Cited by 84
Research works printed but not linked: 5
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- Authors
- Fernandez, A., Brada, M., Zabuliene, L., Karavitaki, N., & Wass, J. A. H.
- Affiliations
- Institute of Cancer Research (GB)
- Royal Marsden NHS Foundation Trust (GB)
- National Health Service (GB)
- Venue
- Endocrine-Related Cancer
- Publisher
- Bioscientifica
- Published
- 2009-09
- Volume
- 16
- Issue
- 3
- Pages
- 733-772
- ISSN
- 1351-0088 (ISSN-L)
- 1479-6821
- OpenAlex
- W2095898506
- Semantic Scholar
- 43ae8c700fb95b02dbb26de427569ca899704a37
- Cited by
- 84
- References
- 330
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 12 · 2013: 3 · 2012: 9
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Related Cancer (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- radiation-induced hypopituitarism, radiosensitivity, pituitary irradiation, brain tumors, head and neck neoplasms, whole-body irradiation, endocrine disorders, radiotherapy technique, long-term monitoring, quality of life
- MeSH terms
- Endocrine System Diseases, Humans, Hypopituitarism, Hypothalamo-Hypophyseal System, Radiation Injuries, Radiotherapy, Radiotherapy Dosage
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