The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Estrogen receptor beta in breast cancer.
Open accessAbstract
Estrogen is essential for normal growth and differentiation in the mammary gland. It also supports growth of approximately 50% of primary breast cancers. For this reason, removal of estrogen or blocking of its action with the anti-estrogen, tamoxifen, is the main treatment for estrogen receptor alpha (ERalpha)-positive tumors. In 1996, when oncologists became aware of a second ER, ERbeta, there was some doubt as to whether this receptor would be of importance in breast cancer because the clinical consensus was that responsiveness to tamoxifen is related to the presence of ERalpha in breast cancer. Today we know that ERalpha and ERbeta have distinct cellular distributions, regulate separate sets of genes and can oppose each other's actions on some genes. We also know that ERbeta is widely expressed in both the normal and malignant breast and that there are proliferating cells in the breast which express ERbeta. In this review we summarize what is known about ERbeta in breast cancer and examine the possibility that ERbeta-selective ligands may well represent a useful class of pharmacological tools with a novel target, namely proliferating cells expressing ERbeta.
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Cites
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Cited by
Mechanisms of tamoxifen resistance
Ring, A., & Dowsett, M. (2004) · Endocrine-Related Cancer · doi:10.1677/erc.1.00776 · Cited by 651
Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action
Osborne, C. K., Wakeling, A., & Nicholson, R. I. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601629 · Cited by 414
Reflections on the Discovery and Significance of Estrogen Receptor β
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Self-citationResveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo
Garvin, S., Öllinger, K., & Dabrosin, C. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.01.031 · Cited by 351
Bhardwaj, P., Au, C. C., Benito-Martin, A., Ladumor, H., Oshchepkova, S., Moges, R., & Brown, K. A. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.002 · Cited by 233
Metadata
- Authors
- Palmieri, C., Cheng, G. J., Saji, S., Zelada-Hedman, M., Wärri, A., Weihua, Z., Van Noorden, S., Wahlstrom, T., Coombes, R. C., Warner, M., & Gustafsson, J.-A.
- Venue
- Endocrine-related cancer
- Publisher
- Bioscientifica
- Published
- 2002-03
- Volume
- 9
- Issue
- 1
- Pages
- 1-13
- ISSN
- 1351-0088 (ISSN-L)
- OpenAlex
- W2139768136
- Cited by
- 257
- References
- 54
- FWCI
- 13.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Palmieri, C., Cheng, G. J., Saji, S., Zelada-Hedman, M., Wärri, A., Weihua, Z., Van Noorden, S., Wahlstrom, T., Coombes, R. C., Warner, M., & Gustafsson, J.-A. (2002). Estrogen receptor beta in breast cancer. Endocrine-related cancer. https://doi.org/10.1677/erc.0.0090001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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