The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development
Open accessAbstract
Previous studies have equated FOXL2 as a crucial actor in the ovarian differentiation process in different vertebrate species. Its transcriptional extinction in the polled intersex syndrome (PIS) leads primarily to a drastic decrease of aromatase (CYP19) expression in the first steps of goat ovarian development. In this study, we provide a better characterization of early ovarian development in goat, and we provide experimental evidence demonstrating that FOXL2 represents a direct transcriptional activator of the CYP19 gene through its ovarian-specific promoter 2. Moreover, the ovarian location of FOXL2 and CYP19 proteins, together with their expression profiles in the female gonads, stress the involvement of FOXL2 co-factor(s) for regulating CYP19 transcription. Expressional analyses show that activin-βA can be considered as a strong candidate for being one of these FOXL2 co-factors. Finally, we discuss evidence for a role of activin and estrogens in somatic and germinal cell proliferation occurring before germ cell meiosis. This period, of 20 days in goat, seems to have no equivalent in mouse. This species-specific difference could explain the phenotype discrepancy observed between XX goat PIS−/− and XX mouse Foxl2−/−.
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Cites
Biochemical and Biophysical Research Communications
(1960) · Nature · doi:10.1038/186124d0 · Cited by 6,700
Molecular and cellular endocrinology
(1995) · Journal of Endocrinology · doi:10.1677/joe.0.147so19 · Cited by 1,991
The International Journal of Developmental Biology
Aréchaga, J. (2012) · Dialnet (Universidad de la Rioja) · Cited by 1,273
Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., et al. (2001) · Nature Genetics · doi:10.1038/84781 · Cited by 990
General and Comparative Endocrinology
(1961) · Nature · doi:10.1038/1901061d0 · Cited by 930
Fisher, C. R., Graves, K. H., Parlow, A. F., & Simpson, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6965 · Cited by 867
Forkhead Transcription Factors: Key Players in Development and Metabolism
Carlsson, P., & Mahlapuu, M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0780 · Cited by 840
Schmidt, D., Ovitt, C. E., Anlag, K., Fehsenfeld, S., Gredsted, L., Treier, A.-C., & Treier, M. (2004) · Development · doi:10.1242/dev.00969 · Cited by 762
Molecular Reproduction and Development
(2006) · Molecular Reproduction and Development · doi:10.1002/(issn)1098-2795 · Cited by 706
Five years on the wings of fork head
Kaufmann, E., & Knöchel, W. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00539-4 · Cited by 661
Cited by
Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
Uhlenhaut, N. H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier, A.-C., Klugmann, C., Klasen, C., Holter, N. I., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.021 · Cited by 962
Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary
Shah, S. P., Köbel, M., Senz, J., Morin, R. D., Clarke, B. A., Wiegand, K. C., Leung, G., Zayed, A., Mehl, E., Kalloger, S. E., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902542 · Cited by 768
Wang, D.-S., Kobayashi, T., Zhou, L.-Y., Paul-Prasanth, B., Ijiri, S., Sakai, F., Okubo, K., Morohashi, K.-I., & Nagahama, Y. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0248 · Cited by 507
Metadata
- Authors
- Pannetier, M., Fabre, S., Batista, F., Kocer, A., Renault, L., Jolivet, G., Mandon-Pépin, B., Cotinot, C., Veitia, R., & Pailhoux, E.
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2006-06
- Volume
- 36
- Issue
- 3
- Pages
- 399-413
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2161291489
- Cited by
- 263
- References
- 41
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pannetier, M., Fabre, S., Batista, F., Kocer, A., Renault, L., Jolivet, G., Mandon-Pépin, B., Cotinot, C., Veitia, R., & Pailhoux, E. (2006). FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development. Journal of Molecular Endocrinology. https://doi.org/10.1677/jme.1.01947
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