Guanethidine treatment does not block the ability of central leptin administration to decrease blood glucose concentrations in streptozotocin-induced diabetic rats
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Leptin, administered either into the ventricles of the brain or systemically, has been shown to normalize blood glucose concentrations in streptozotocin (STZ)-induced diabetic rats. We hypothesized that an intact sympathetic nervous system is necessary for centrally administered leptin to normalize or attenuate high blood glucose concentrations in STZ-induced diabetic rats. Young male Wistar rats (∼50 g) were treated every other day with either s.c. guanethidine (100 mg/kg) or vehicle for 2 weeks. Rats were then implanted with an intracerebroventricular cannula directed to the lateral ventricle and made diabetic with an i.v. injection of STZ (50 mg/kg). Half of the animals in each group were given daily injections of leptin (10 μl), while the remaining animals received vehicle injections. Blood glucose concentrations were measured daily and tissue norepinephrine content was determined by high performance liquid chromatography at the end of the study. Guanethidine pretreatment did not block the ability of centrally administered leptin to decrease blood glucose concentrations in diabetic rats. This suggests that the sympathetic nervous system does not mediate the leptin-induced attenuation of high blood glucose concentrations observed in diabetic rats.
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Intracerebroventricular administration of leptin normalizes blood glucose levels in STZ-diabetic rats at doses that are ineffective when administered peripherally.
“i.c.v. administration of leptin normalizes blood glucose levels in STZ-diabetic rats at doses that are ineffective when administered peripherally (43, 82, 104, 190).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [190]
Combined α- and β-adrenergic receptor blockade does not attenuate the effect of leptin to restore euglycemia in rats with uDM.
“neither chemical denervation of the SNS (8) nor combined ␣and b-adrenergic receptor blockade attenuated the effect of leptin to restore euglycemia in rats with uDM”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [8]
Chemical denervation of the SNS does not attenuate the effect of leptin to restore euglycemia in rats with uDM.
“neither chemical denervation of the SNS (8) nor combined ␣and b-adrenergic receptor blockade attenuated the effect of leptin to restore euglycemia in rats with uDM”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [8]
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References 21 · Cited by 8
- Authors
- Wang, J., Wernette, C. M., Judd, R. L., Huggins, K. W., & White, B. D.
- Affiliations
- Auburn University (US)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2008-07-03
- Volume
- 198
- Issue
- 3
- Pages
- 541-548
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2109084793
- Cited by
- 8
- References
- 21
- Citations by year
- 2022: 1 · 2017: 1 · 2014: 1 · 2013: 2
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Auburn University
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- leptin, guanethidine, streptozotocin-induced diabetes, blood glucose, intracerebroventricular administration, sympathetic nervous system, norepinephrine, diabetes mellitus, glucose homeostasis
- MeSH terms
- Animals, Blood Glucose, Body Weight, Adipose Tissue, Brown, Diabetes Mellitus, Experimental, Guanethidine, Liver, Male, Norepinephrine, Spleen, Sympathetic Nervous System, Rats, Wistar, Adrenergic Agents, Leptin, Rats, Adipose Tissue, White
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