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PREMATURE AFTER INFUSION OF CORTISOL INTO PARTURITION CORTICOTROPHIN OR FOETAL LAMBS
Abstract
SUMMARY: Continuous and prolonged administration of corticotrophin (ACTH) to single foetal lambs at gestational ages of 88–129 days was followed by parturition on the 4th–7th day of the infusion. At birth, the foetal adrenal glands weighed at least as much as those of normal lambs at term. Infusions of cortisol into the foetus at a rate of 50 mg./24 hr. was followed by premature parturition within 5 days. Prolonged administration of the same doses of ACTH or cortisol to pregnant ewes and of oestradiol-17β to a foetus did not cause parturition. These observations indicate that the pituitary-adrenal system of the foetus may play an active part in the initiation of parturition in the ewe.
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“Multiple factors initiate parturition, including fetal cortisol, maternal drop in progesterone, oxytocin, prostaglandin F2α and other endocrine factors56–59.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [56]
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Corticosteroids in the prevention and management of bronchopulmonary dysplasia
Grier, D. G., & Halliday, H. L. (2003) · Seminars in Neonatology · doi:10.1016/s1084-2756(02)00189-6 · Cited by 51
Brown, J. L., Sones, J. L., Angulo, C. N., Abbott, K., Miller, A. D., Boehm, U., & Roberson, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45997-0 · Cited by 13
Metadata
- Authors
- LIGGINS, G. C.
- Corresponding author
- LIGGINS, G. C.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1968-10-01
- Volume
- 42
- Issue
- 2
- Pages
- 323-329
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2009958636
- Cited by
- 331
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 8 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 30.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- preterm birth, ACTH, cortisol, pituitary-adrenal axis, fetal sheep, estradiol, ewes, gestation
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Animals, Animals, Newborn, Estradiol, Female, Fetus, Hydrocortisone, Labor, Obstetric, Labor, Induced, Organ Size, Pituitary-Adrenal System, Pregnancy, Sheep
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