The DOI matches its Crossref record.
A SOLUBLE ANDROGEN RECEPTOR IN THE CYTOPLASM OF RAT PROSTATE
Abstract
SUMMARY: A thermolabile protein with the properties of a steroid 'receptor' was identified in the cytoplasmic or 105,000 g supernatant fraction of the rat prostate. The receptor has a particular binding specificity towards 5αdihydrotestosterone. Testosterone is bound to a lesser extent but other steroids, including certain androgenic hormones, are not bound. The sedimentation coefficient of 8·0 s and the frictional ratio of 1·96, equivalent to a molecular weight of 2·74 × 10 5, clearly distinguish the soluble androgen-receptor from the androgen-binding globulin in serum and the androgen-receptor in the prostatic nucleus. Like the nuclear receptor, however, the soluble receptor is probably an acidic protein. Both cysteine and tryptophan residues appear necessary for maintaining the functional configuration of the receptor.
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Citations
Cited by
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
A history of prostate cancer treatment.
Denmeade, S. R., & Isaacs, J. T. (2002) · Nature reviews. Cancer · doi:10.1038/nrc801 · Cited by 591
Baulieu, E.-E., Atger, M., Best-Belpomme, M., Corvol, P., Courvalin, J.-C., Mester, J., Milgrom, E., Robel, P., Rochefort, H., & Catalogne, D. D. (1976) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)60974-7 · Cited by 341
Fang, S., & Liao, S. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62526-8 · Cited by 318
Simard, J., Luthy, I., Guay, J., Bélanger, A., & Labrie, F. (1986) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(86)90132-2 · Cited by 256
Metadata
- Authors
- MAINWARING, W. I. P.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1969-12
- Volume
- 45
- Issue
- 4
- Pages
- 531-541
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2051166231
- Cited by
- 290
- References
- 0
- FWCI
- 50.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A SOLUBLE ANDROGEN RECEPTOR IN THE CYTOPLASM OF RAT PROSTATE. https://app.cochat.ai/papers/10.1677/joe.0.0450531
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- MAINWARING, W. I. P. (1969). A SOLUBLE ANDROGEN RECEPTOR IN THE CYTOPLASM OF RAT PROSTATE. Journal of Endocrinology. https://doi.org/10.1677/joe.0.0450531
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
