CoChat
Sign Up
Cited by 340Renin-Angiotensin System StudiesHormonal Regulation and HypertensionCoagulation, Bradykinin, Polyphosphates, and Angioedema

The DOI matches its Crossref record.

RISE IN PLASMA CONCENTRATION OF ALDOSTERONE DURING LONG-TERM ANGIOTENSIN II SUPPRESSION

STAESSEN, J., LIJNEN, P., FAGARD, R., VERSCHUEREN, L. J., AMERY, A.·1981·Journal of Endocrinology
DOI 10.1677/joe.0.0910457
Open this paper in CoChat — free account

Abstract

The plasma concentration of aldosterone was followed in seven hypertensive patients before and during long-term angiotensin II suppression with the orally active angiotensin-I-converting-enzyme inhibitor, captopril. The plasma concentration of aldosterone decreased initially from 74 to 21 pg/ml (P less than 0.05) after 1 month of administration of captopril. Thereafter the plasma concentration of aldosterone began to rise and after 1 year reached a level of 165 pg/ml. During long-term captopril therapy the plasma renin activity remained increased and the plasma angiotensin II concentration suppressed. The mechanism responsible for the late rise of the plasma concentration of aldosterone during long-term angiotensin II suppression with captopril remains to be elucidated. A sizeable and lasting hypotensive effect was observed in all patients.

Overview

Integrity signals

Registry

Crossref · 10.1677/joe.0.0910457

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Items 301–340 of 340

Related

See all

Metadata

Authors
STAESSEN, J., LIJNEN, P., FAGARD, R., VERSCHUEREN, L. J., & AMERY, A.
ORCID
STAESSEN, J.
Venue
Journal of Endocrinology
Publisher
Bioscientifica
Published
1981-12-01
Volume
91
Issue
3
Pages
457-465
ISSN
  • 0022-0795 (ISSN-L)
  • 1479-6805
DOI
10.1677/joe.0.0910457
OpenAlex
W1971680322
Cited by
339
References
0
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 10 · 2014: 20 · 2013: 7 · 2012: 14
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Keywords
aldosterone, captopril, ACE inhibitors, hypertension, plasma renin activity, renin-angiotensin system, long-term drug therapy, hypotension
MeSH terms
Adult, Aldosterone, Angiotensin II, Captopril, Depression, Chemical, Female, Humans, Hypertension, Male, Middle Aged, Proline, Renin, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review