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The endocrine regulation of spermatogenesis: independent roles for testosterone and FSH
Abstract
Introduction The adult testis has two important roles, namely the production of spermatozoa (fertility) and the secretion of testosterone which is needed for the expression of secondary sexual characteristics (virility). These functions depend on stimulation by the pituitary gonadotrophins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are stimulated by hypothalamic gonadotrophin-releasing hormone (GnRH). Testosterone is secreted by the Leydig cells under LH stimulation and is essential for promoting spermatogenesis. While FSH has a role in the development of the immature testis (Orth 1993), controversy persists as to whether FSH is essential for the maintenance of adult spermatogenesis. A better understanding of the hormonal requirements of adult spermatogenesis is needed for the development of rational treatments for human infertility and in designing contraceptive strategies. This review will outline the data regarding the roles of testosterone and FSH in adult spermatogenesis and follows previous discussion in this Journal (Rommerts 1988, Sharpe
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Citations
Cited by
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943
The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions
Heinlein, C. A., & Chang, C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0070 · Cited by 568
Cheng, C. Y., & Mruk, D. D. (2002) · Physiological Reviews · doi:10.1152/physrev.00009.2002 · Cited by 567
Men with acquired hypogonadotropic hypogonadism treated with testosterone may be fertile
Drincic, A., Arseven, O. K., Sosa, E., Mercado, M., Kopp, P., & Molitch, M. E. (2003) · Pituitary · doi:10.1023/a:1026232124988 · Cited by 11
Metadata
- Authors
- McLachlan, R. I., Wreford, N. G., O'Donnell, L., de Kretser, D. M., & Robertson, D. M.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1996-01
- Volume
- 148
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2087247861
- Cited by
- 246
- References
- 0
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- McLachlan, R. I., Wreford, N. G., O'Donnell, L., de Kretser, D. M., & Robertson, D. M. (1996). The endocrine regulation of spermatogenesis: independent roles for testosterone and FSH. Journal of Endocrinology. https://doi.org/10.1677/joe.0.1480001
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