Adrenal and gonadal function in hypothyroid adult male rats
Abstract
The functional relationship between thyroid, adrenal and gonadal hormones was investigated using adult male rats. Hypothyroidism was produced by the administration of 4-methyl-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Plasma concentrations of TSH dramatically increased, whereas plasma concentrations of tri-iodothyronine and thyroxine decreased in thiouraciltreated rats as compared with euthyroid rats. Hypothyroidism increased basal levels of plasma ACTH and pituitary content of ACTH. The pituitary responsiveness to CRH for ACTH release markedly increased, whereas the adrenal responsiveness to ACTH for corticosterone release decreased. These results indicated that hypothyroidism causes adrenal dysfunction in adult male rats. Pituitary contents of LH and prolactin decreased in hypothyroid rats as compared with euthyroid rats. In addition, hypothyroidism lowered pituitary LH responsiveness to LHRH. Testicular responsiveness to human chorionic gonadotrophin for testosterone release, however, was not different between euthyroid and hypothyroid animals. These results indicated that hypothyroidism causes adrenal dysfunction and results in hypersecretion of ACTH from the pituitary gland. Adrenal dysfunction may contribute to the inhibition of LHRH secretion from the hypothalamus, possibly mediated by excess CRH.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the presence of reduced PRA, ALDO secretion could be sustained by ACTH.
“In the presence of a reduced PRA, ALDO secretion could be sustained by the pituitary hormone ACTH; according to this finding, recent studies have reported a reactive increase in ACTH secretion in response to adrenal cortex dysfunction induced by acute hypothyroidism in experimental animals (33,34).”
From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [33]
The citation lists haven’t been fetched yet
Cited by 48
- Authors
- Tohei, A., Akai, M., Tomabechi, T., Mamada, M., & Taya, K.
- Affiliations
- Tokyo University of Agriculture and Technology (JP)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1997-01-01
- Volume
- 152
- Issue
- 1
- Pages
- 147-154
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2023223088
- Cited by
- 48
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universities Federation for Animal Welfare
- Soochow University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- hypothyroidism, adrenal dysfunction, gonadal function, ACTH hypersecretion, corticosterone, thyroid-stimulating hormone, triiodothyronine, thyroxine, luteinizing hormone, prolactin, luteinizing hormone receptor, human chorionic gonadotropin, testosterone, corticotropin-releasing factor, pituitary responsiveness, hypothalamic-pituitary-thyroid axis, male rats
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Animals, Corticosterone, Corticotropin-Releasing Hormone, Chorionic Gonadotropin, Hypothyroidism, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Pituitary Gland, Prolactin, Testis, Testosterone, Thyrotropin, Thyroxine, Triiodothyronine, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
