The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The new biology of aldosterone
Open accessAbstract
Classically, aldosterone is synthesised in the adrenal zona glomerulosa and binds to specific mineralocorticoid receptors located in the cytosol of target epithelial cells. Translocation of the resulting steroid receptor complex to the cell nucleus modulates gene expression and translation of specific ‘aldosterone-induced’ proteins that regulate electrolyte and fluid balance. However, non-epithelial and rapid non-genomic actions of aldosterone have also been described that account for a variety of actions of aldosterone that contribute to blood pressure homeostasis. These include key actions on endothelial cells and on cardiac tissue. There is also evidence that aldosterone can be synthesised in other tissues; the most convincing evidence relates to the central nervous system. However, suggestions that aldosterone is produced in the heart remain controversial, and adrenal derived aldosterone is the principal source of circulating and locally available hormone. Recent studies have shown major therapeutic benefits of mineralocorticoid receptor antagonism in cardiac failure, which emphasise the importance of aldosterone in causing adverse cardiovascular pathophysiological effects. Additional evidence demonstrates that aldosterone levels predict development of high blood pressure in normotensive subjects, while it is now clear that increased aldosterone action contributes to hypertension and cardiovascular damage in approximately 10% of patients with established hypertension. These new findings highlight the role of aldosterone as a key cardiovascular hormone and extend our understanding of its role in determining adverse cardiovascular outcomes.
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Cites
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Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy
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Cited by
Nuclear receptors: Decoding metabolic disease
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Plasma aldosterone is independently associated with the metabolic syndrome
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Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor
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Impact of excess aldosterone on glucose homeostasis in adult male rat
Selvaraj, J., Muthusamy, T., Srinivasan, C., & Balasubramanian, K. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.06.030 · Cited by 38
Metadata
- Authors
- Connell, J. M. C., & Davies, E.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2005-07
- Volume
- 186
- Issue
- 1
- Pages
- 1-20
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2117663124
- Cited by
- 356
- References
- 12
- FWCI
- 13.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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