Parathyroid hormone: past and present
Open accessAbstract
Research on parathyroid hormone (PTH) has undergone four rather distinctive phases, beginning just before the turn of the 20th century. Early debates about the function of the parathyroids were resolved by 1925, when understanding the role of PTH led to comprehending the action of the glands in calcium physiology. Elucidation of the pathophysiology of hormone excess (severe bone loss) and deficiency (hypocalcemia) continued over the following decades. With the advent of advances in chemical and molecular biology, the structure of PTH and its principal receptor (PTHrP-receptor [PTHR1]) were established. Tests with purified hormonal peptide in humans led to the surprising, even paradoxical, finding that PTH can be used pharmacologically to build bone, providing a dramatic therapeutic impact on osteoporosis. These developments have stimulated the field of calcium and bone biology and posed new questions about the role of PTH as well as possible new directions in therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Parathyroid hormone has catabolic effects on bone tissue and increases vitamin D synthesis, which raises plasma calcium levels.
“This hormone has catabolic effects on bone tissue and increases vitamin D synthesis, which raises the plasma calcium levels.303”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [303]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 62 · Cited by 327
Research works printed but not linked: 11
- Albright F & Ellsworth R 1990 Uncharted Seas. Ed L Loriaux. Portland, OR: Kalmia Press. (Posthumous publication.)
- Boothby WM 1921 The parathyroid glands: a review of the literature. Endocrinology 5 403-440.
- Delmas PD & Chapurlat RD 2005 Osteoporosis. In Endocrinology, edn 5, vol 2, pp 1751-1769. Eds LL DeGroot & JL Jameson. Philadelphia: Elsevier & Saunders.
- Ekins R 1981 Towards immunoassays of greater sensitivity, specificity and speed: an overview. In Monoclonal Antibodies and Developments in Immunoassay, pp 3-21. Eds A Albertini & R Ekins. Amsterdam: Elsevier/North Holland.
- Eds LL DeGroot & JL Jameson. Philadelphia: Elsevier.
- Martin TJ, Findlay DM & Sexton PM 2005 Calcitonin. In Endocrinology, edn 5, vol 2, pp 1419-1433. Eds LL DeGroot & JL Jameson. Philadelphia: Elsevier & Saunders.
- Njeh CF, Jergas M & Genant HK 2005 Bone density and imaging of osteopororis. In Endocrinology, edn 5, vol 2, pp 1673-1695. Eds LL DeGroot & JL Jameson. Philadelphia: Elsevier & Saunders.
- Paton DN, Findlay L & Burns D 1914-1915 On guanidine or methylguanidin as a toxic agent in the tetany following parathyroidectomy. Journal of Physiology 49 17-18.
- Potts JT Jr 1991 Proceedings of the NIH consensus conference on diagnosis and management of asymptomatic primary hyperparathyroidism. Journal of Bone and Mineral Research 6 (Suppl 2) S1-S165.
- Thakker RV & Jüppner H 2005 Genetic disorders of calcium homeostasis caused by abnormal regulation of parathyroid hormone secretion or responsiveness. In Endocrinology, edn 5, vol 2, pp 1511-1531.
- Eds LL DeGroot & JL Jameson. Philadelphia: Elsevier.
- Authors
- Potts, J. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Potts, John T
- ORCID
- Potts, John T
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2005-12
- Volume
- 187
- Issue
- 3
- Pages
- 311-325
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2132498623
- Cited by
- 327
- References
- 62
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 16 · 2023: 12 · 2022: 8 · 2021: 23 · 2020: 14 · 2019: 15 · 2018: 21 · 2017: 15 · 2016: 15 · 2015: 13 · 2014: 13 · 2013: 21 · 2012: 15
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- parathyroid hormone, parathyroid function, calcium homeostasis, hypocalcemia, hyperparathyroidism, bone loss, parathyroid hormone receptor, parathyroid hormone type 1 receptor, osteoporosis treatment, bone formation
- MeSH terms
- Amino Acid Sequence, Humans, Hyperparathyroidism, Hypoparathyroidism, Ligands, Models, Biological, Osteoporosis, Parathyroid Glands, Parathyroid Hormone, Structure-Activity Relationship, Receptors, Parathyroid Hormone, Anabolic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
