The DOI matches its Crossref record; 240 of the 240 references it cites were found in a registry or an index.
Is dehydroepiandrosterone a hormone?
Abstract
Dehydroepiandrosterone (DHEA) is not a hormone but it is a very important prohormone secreted in large amounts by the adrenals in humans and other primates, but not in lower species. It is secreted in larger quantities than cortisol and is present in the blood at concentrations only second to cholesterol. All the enzymes required to transform DHEA into androgens and/or estrogens are expressed in a cell-specific manner in a large series of peripheral target tissues, thus permitting all androgen-sensitive and estrogen-sensitive tissues to make locally and control the intracellular levels of sex steroids according to local needs. This new field of endocrinology has been called intracrinology. In women, after menopause, all estrogens and almost all androgens are made locally in peripheral tissues from DHEA which indirectly exerts effects, among others, on bone formation, adiposity, muscle, insulin and glucose metabolism, skin, libido and well-being. In men, where the secretion of androgens by the testicles continues for life, the contribution of DHEA to androgens has been best evaluated in the prostate where about 50% of androgens are made locally from DHEA. Such knowledge has led to the development of combined androgen blockade (CAB), a treatment which adds a pure anti-androgen to medical (GnRH agonist) or surgical castration in order to block the access of the androgens made locally to the androgen receptor. In fact, CAB has been the first treatment demonstrated to prolong life in advanced prostate cancer while recent data indicate that it can permit long-term control and probably cure in at least 90% of cases of localized prostate cancer. The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women’s health at menopause.
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Citations
Cites
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BackgroundA Controlled Trial of Leuprolide with and without Flutamide in Prostatic Carcinoma
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Cited by
The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
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Labrie, F. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.06.001 · Cited by 227
Self-citationAndrogen biosynthetic pathways in the human prostate
Luu-The, V., Bélanger, A., & Labrie, F. (2008) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.01.008 · Cited by 169
Labrie, F., Martel, C., & Balser, J. (2011) · Menopause · doi:10.1097/gme.0b013e3181e195a6 · Cited by 143
Metadata
- Authors
- Labrie, F., Luu-The, V, Bélanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C.
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2005-11
- Volume
- 187
- Issue
- 2
- Pages
- 169-196
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2106559777
- Cited by
- 451
- References
- 240
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Labrie, F., Luu-The, V, Bélanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C. (2005). Is dehydroepiandrosterone a hormone? Journal of Endocrinology. https://doi.org/10.1677/joe.1.06264
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
