The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Anemia as a Risk Factor for Cardiovascular Disease and All-Cause Mortality in Diabetes: The Impact of Chronic Kidney Disease
Abstract
Anemia is a potential nontraditional risk factor for cardiovascular disease (CVD). This study evaluated whether anemia is a risk factor for adverse outcomes in people with diabetes and whether the risk is modified by the presence of chronic kidney disease (CKD). Persons with diabetes from four community-based studies were pooled: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study, and Framingham Offspring Study. Anemia was defined as a hematocrit <36% in women and <39% in men. CKD was defined as an estimated GFR of 15 to 60 ml/min per 1.73 m(2). Study outcomes included a composite of myocardial infarction (MI)/fatal coronary heart disease (CHD)/stroke/death and each outcome separately. Cox regression analysis was used to study the effect of anemia on the risk for outcomes after adjustment for potential confounders. The study population included 3015 individuals: 30.4% were black, 51.6% were women, 8.1% had anemia, and 13.8% had CKD. Median follow-up was 8.6 yr. There were 1215 composite events, 600 MI/fatal CHD outcomes, 300 strokes, and 857 deaths. In a model with a CKD-anemia interaction term, anemia was associated with the following hazard ratios (95% confidence intervals) in patients with CKD: 1.70 (1.24 to 2.34) for the composite outcome, 1.64 (1.03 to 2.61) for MI/fatal CHD, 1.81 (0.99 to 3.29) for stroke, and 1.88 (1.33 to 2.66) for all-cause mortality. Anemia was not a risk factor for any outcome in those without CKD (P > 0.2 for all outcomes). In persons with diabetes, anemia is primarily a risk factor for adverse outcomes in those who also have CKD.
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Cites
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Self-citationThe Cardiovascular Health Study: design and rationale.
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D'Agostino, R. B., Grundy, S., Sullivan, L. M., Wilson, P., & for the CHD Risk Prediction Group (2001) · JAMA · doi:10.1001/jama.286.2.180 · Cited by 2,108
Ezekowitz, J. A., McAlister, F. A., & Armstrong, P. W. (2003) · Circulation · doi:10.1161/01.cir.0000052622.51963.fc · Cited by 866
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Anemia predicts mortality in severe heart failure
Mozaffarian, D., Nye, R., & Levy, W. C. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00425-x · Cited by 294
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Pfeffer, M. A., Burdmann, E. A., Chen, C.-Y., Cooper, M. E., de Zeeuw, D., Eckardt, K.-U., Feyzi, J. M., Ivanovich, P., Kewalramani, R., Levey, A. S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907845 · Cited by 2,096
Self-citation(2007) · Endocrine Practice · doi:10.4158/ep.13.s1.1 · Cited by 699
Gardner, W. M., Razo, C., McHugh, T. A., Hagins, H., Vilchis-Tella, V. M., Hennessy, C., Taylor, H. J., Perumal, N., Fuller, K., Cercy, K. M., et al. (2023) · The Lancet Haematology · doi:10.1016/s2352-3026(23)00160-6 · Cited by 642
Erythropoietic response and outcomes in kidney disease and type 2 diabetes
Solomon, S. D., Uno, H., Lewis, E. F., Eckardt, K.-U., Lin, J., Burdmann, E. A., de Zeeuw, D., Ivanovich, P., Levey, A. S., Parfrey, P., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005109 · Cited by 473
Self-citationImpact of anemia on hospitalization and mortality in older adults
Culleton, B. F., Manns, B. J., Zhang, J., Tonelli, M., Klarenbach, S., & Hemmelgarn, B. R. (2006) · Blood · doi:10.1182/blood-2005-10-4308 · Cited by 455
Metadata
- Authors
- Vlagopoulos, P. T., Tighiouart, H., Weiner, D. E., Griffith, J., Pettitt, D., Salem, D. N., Levey, A. S., & Sarnak, M. J.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2005-11
- Volume
- 16
- Issue
- 11
- Pages
- 3403-3410
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2141767690
- Cited by
- 314
- References
- 6
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Anemia as a Risk Factor for Cardiovascular Disease and All-Cause Mortality in Diabetes: The Impact of Chronic Kidney Disease. https://app.cochat.ai/papers/10.1681/asn.2005030226
- The paper
- Vlagopoulos, P. T., Tighiouart, H., Weiner, D. E., Griffith, J., Pettitt, D., Salem, D. N., Levey, A. S., & Sarnak, M. J. (2005). Anemia as a Risk Factor for Cardiovascular Disease and All-Cause Mortality in Diabetes: The Impact of Chronic Kidney Disease. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2005030226
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
