The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice
Open accessAbstract
Functionally significant polymorphisms in endothelial nitric oxide synthase (eNOS) and reduced vascular eNOS activity have been associated with increased human diabetic nephropathy (DN), but the pathogenic role of eNOS deficiency in the development of DN has not yet been confirmed. This study characterizes the severity of DN in eNOS(-/-) mice that were backcrossed to C57BLKS/J db/db mice. Although the severity of hyperglycemia was similar to C57BLKS/J db/db mice, by 26 wk, eNOS(-/-) C57BLKS/J db/db mice exhibited dramatic albuminuria, arteriolar hyalinosis, increased glomerular basement membrane thickness, mesangial expansion, mesangiolysis, and focal segmental and early nodular glomerulosclerosis. Even more remarkable, eNOS(-/-) C57BLKS db/db exhibited decreases in GFR to levels <50% of that in eNOS(+/+) C57BLKS db/db, as confirmed by increased serum creatinine. In summary, eNOS(-/-) db/db mice provide the most robust model of type II DN that has been described to date and support a role for deficient eNOS-derived NO production in the pathogenesis of DN.
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Cites
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · cited 2×
“There is growing evidence that endothelial cell dysfunction contributes to hypertension and microvascular complications of diabetes (2,23).”
BackgroundTherapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.
Coleman, D. L., Leiter, E. H., & Schwizer, R. W. (1982) · Diabetes · doi:10.2337/diab.31.9.830 · Cited by 317 · cited 1×
“In addition, when the db/db mutation is on the C57BLKS background, mice develop a late ( 4 mo) insulitis so that insulin levels are inappropriately low for the level of hyperglycemia (22).”
Background
Cited by
Mechanisms of Diabetic Complications
Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890
Mouse Models of Diabetic Nephropathy
Brosius, F. C., Alpers, C. E., Bottinger, E. P., Breyer, M. D., Coffman, T. M., Gurley, S. B., Harris, R. C., Kakoki, M., Kretzler, M., Leiter, E. H., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009070721 · Cited by 895
Self-citationFujita, H., Morii, T., Fujishima, H., Sato, T., Shimizu, T., Hosoba, M., Tsukiyama, K., Narita, T., Takahashi, T., Drucker, D. J., et al. (2014) · Kidney International · doi:10.1038/ki.2013.427 · Cited by 336
Self-citationLi, J., Qu, X., & Bertram, J. F. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090096 · Cited by 316
Lenoir, O., Jasiek, M., Hénique, C., Guyonnet, L., Hartleben, B., Bork, T., Chipont, A., Flosseau, K., Bensaada, I., Schmitt, A., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1049799 · Cited by 296
Metadata
- Authors
- Zhao, H. J., Wang, S., Cheng, H., Zhang, M.-Z., Takahashi, T., Fogo, A. B., Breyer, M. D., & Harris, R. C.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2006-10
- Volume
- 17
- Issue
- 10
- Pages
- 2664-2669
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2139947959
- Cited by
- 359
- References
- 2
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, H. J., Wang, S., Cheng, H., Zhang, M.-Z., Takahashi, T., Fogo, A. B., Breyer, M. D., & Harris, R. C. (2006). Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2006070798
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