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Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy
Open accessAbstract
Understanding the pathogenesis of albuminuria in diabetic nephropathy is important to improve methods for early diagnosis and treatment. In this study, we addressed whether albuminuria in diabetes results from altered glomerular filtration and/or altered processing of filtered albumin by the proximal tubule. Type 1 diabetic Munich Wistar rats developed albuminuria after 12 wk of diabetes. Intravital two-photon microscopy revealed similar glomerular permeability in the diabetic and control animals, assessed using both albumin-Alexa568 and 69-kD FITC-dextran; however, diabetic animals demonstrated significantly less filtered fluorescent albumin in renal proximal tubule (PT) cells compared with control animals. We also observed increased albumin-derived urinary peptide excretion in diabetic animals, and hyperglycemia modulated this peptideuria. In conclusion, in the early stages of diabetic nephropathy, the PT plays a major role in the development of albuminuria, which may be preceded by peptideuria.
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Cites
Insulin restriction and associated morbidity and mortality in women with type 1 diabetes
Goebel-Fabbri, A. E., Fikkan, J., Franko, D. L., Pearson, K., Anderson, B. J., & Weinger, K. (2008) · Diabetes Care · doi:10.2337/dc07-2026 · Cited by 352
Cited by
Pathophysiology of the Diabetic Kidney
Vallon, V., & Komers, R. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100049 · Cited by 259
Muller, P. Y., & Dieterle, F. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903114174 · Cited by 62
Yiu, W. H., Wong, D. W. L., Chan, L. Y. Y., Leung, J. C. K., Chan, K. W., Lan, H. Y., Lai, K. N., & Tang, S. C. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088894 · Cited by 50
Metadata
- Authors
- Russo, L. M., Sandoval, R. M., Campos, S. B., Molitoris, B. A., Comper, W. D., & Brown, D.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-03
- Volume
- 20
- Issue
- 3
- Pages
- 489-494
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2127006232
- Cited by
- 261
- References
- 1
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Russo, L. M., Sandoval, R. M., Campos, S. B., Molitoris, B. A., Comper, W. D., & Brown, D. (2009). Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2008050503
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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