The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238

Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients

Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

Woods, A., Dickerson, K., Heath, R. B., Hong, S. P., Momcilovic, M., Johnstone, S. R., Carlson, M., & Carling, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.005 · Cited by 1,418

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396

Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1

Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971

Rearrangements of the Cytoskeleton and Cell Contacts Induce Process Formation during Differentiation of Conditionally Immortalized Mouse Podocyte Cell Lines

Mundel, P. H., Reiser, J., Zúñiga, A., Pavenstädt, H., Davidson, G. R., Kriz, W., & Zeller, R. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3739 · Cited by 876

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 677

Adiponectin Enhances Fatty Acid Signaling in Human Taste Cells by Increasing Surface Expression of CD36

Lin, F., Liu, Y., Rudeski-Rohr, T., Dahir, N. S., Calder, A. N., & Gilbertson, T. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065801 · Cited by 16

Insights from insulin resistance pathways: Therapeutic approaches against Alzheimer associated diabetes mellitus

Fauzi, A., Thoe, E. S., Quan, T. Y., & Yin, A. C. Y. (2023) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2023.108629 · Cited by 17

Small-molecule agonist AdipoRon alleviates diabetic retinopathy through the AdipoR1/AMPK/EGR4 pathway

Wang, Y., Liu, Y., Fang, J., Xing, X., Wang, H., Shi, X., Liu, X., Niu, T., & Liu, K. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04783-3 · Cited by 16

Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy

Rajput, S., Kulkarni, C., Sharma, S., Tomar, M. S., Khatoon, S., Gupta, A., Sanyal, S., Shrivastava, A., Ghosh, J. K., & Chattopadhyay, N. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01509-x · Cited by 15

AdipoRon prevents -thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway

Hu, X., Ouyang, Q., Wang, L., Li, T., Xie, X., & Liu, J. L. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy152 · Cited by 15

AdipoRon promotes diabetic fracture repair through endochondral ossification-based bone repair by enhancing survival and differentiation of chondrocytes

Wang, Z., Tang, J., Li, Y., Wang, Y., Guo, Y., Tu, Q., Chen, J., & Wang, C. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111757 · Cited by 15

Role of adiponectin in osteoarthritis

Feng, X., Xiao, J., & Bai, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.992764 · Cited by 15

Adiponectin protects against myocardial ischemia–reperfusion injury: a systematic review and meta-analysis of preclinical animal studies

Yue, H., Zhang, Q., Chang, S., Zhao, X., Wang, M., & Li, W. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02028-w · Cited by 14

Role of peroxisomes in the pathogenesis and therapy of renal fibrosis

Zhang, D., Zhang, Y.-H., Liu, B., Yang, H., Li, G., Zhou, H., & Wang, Y. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156173 · Cited by 14

Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy

Kim, T., Oum, S.-J., Lim, J. H., Kim, Y., Kim, E. N., Jin, Y., Hong, Y. A., Chae, S. Y., Choi, B. S., Kim, H. W., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02326-5 · Cited by 13

The mysterious association between adiponectin and endometriosis

Zhao, Y.-Q., Ren, Y., Li, B., Wei, C., & Yu, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1396616 · Cited by 13

Blockade of STARD3-mediated cholesterol transport alleviates diabetes-induced podocyte injury by reducing mitochondrial cholesterol accumulation

Hu, J., Zhu, Z., Zhang, Z., Hu, H., & Yang, Q. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122722 · Cited by 13

The Neuroprotective Effect of the Adiponectin Receptor Agonist AdipoRon on Glutamate-Induced Cell Death in Rat Primary Retinal Ganglion Cells

Uchida, T., Ueta, T., Honjo, M., & Aihara, M. (2019) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2018.0152 · Cited by 13

Reduced serum CTRP12 levels in type 2 diabetes are associated with renal dysfunction

Du, J., Xu, J., Wang, X., Liu, Y., Zhao, X., & Zhang, H. (2020) · International Urology and Nephrology · doi:10.1007/s11255-020-02591-y · Cited by 13

AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress

Xiong, S., Han, Y., Gao, P., Zhao, H., Jiang, N., & Sun, L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6104375 · Cited by 13

Adenosine monophosphate activated protein kinase (AMPK) is essential for the memory improving effect of adiponectin

Rashtiani, S., Goudarzi, I., Jafari, A., & Rohampour, K. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135721 · Cited by 13

The impact of obesity on bone health: molecular pathways, metabolic interactions, and associated pathologies

Bagherifard, A., Hemmatyar, A., Khosravi, K., Rouzbahani, A., Mokhtari, K., Yahyazedeh, H., & Tanzadehpanah, H. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01907-1 · Cited by 16

Adiponectin agonist treatment in diabetic pregnant rats

Gázquez, A., Rodríguez, F., Sánchez-Campillo, M., Gascón, L. M., Arnao, M. B., Saura-Garre, P., Albaladejo-Otón, M. D., & Larqué, E. (2021) · Journal of Endocrinology · doi:10.1530/joe-20-0617 · Cited by 12

Unraveling the rationale and conducting a comprehensive assessment of AdipoRon (adiponectin receptor agonist) as a candidate drug for diabetic nephropathy and cardiomyopathy prevention and intervention—a systematic review

Laurindo, L. F., Laurindo, L. F., Rodrigues, V. D., Catharin, V. M. C. S., Simili, O. A. G., Barboza, G. D. O., Catharin, V. C. S., Sloan, K. P., & Barbalho, S. M. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03362-7 · Cited by 12

Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice

Xiao, W., & Zhang, L. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000488 · Cited by 12

Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice

Sun, R., Han, M., Liu, Y., Su, Y., Shi, Q., Huang, L., Kong, L., Li, W., & Li, W. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.13136 · Cited by 11

Antidiabetic features of AdipoAI, a novel AdipoR agonist

Ahuja, A., Zboinski, E., das, S., Zhu, X., Ma, Q., Xie, Y., Tu, Q., & Chen, J. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3910 · Cited by 11

Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type-1 receptor and adiponectin receptor-1

Zha, D., Yao, T., Bao, L., Gao, P. H., & Wu, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.044 · Cited by 11

A Potential Theragnostic Regulatory Axis for Arthrofibrosis Involving Adiponectin (ADIPOQ) Receptor 1 and 2 (ADIPOR1 and ADIPOR2), TGFβ1, and Smooth Muscle α-Actin (ACTA2)

Bayram, B., Owen, A. R., Dudakovic, A., Dagneaux, L., Turner, T. W., Bettencourt, J. W., Limberg, A. K., Tibbo, M. E., Morrey, M. E., Sánchez‐Sotelo, J., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113690 · Cited by 11

AdipoRon ameliorates chronic ethanol induced cardiac necroptosis by reducing ceramide mediated mtROS

Qian, Y., Qi, Y., Lin, J., Zhang, T., Mo, L., Xue, Q., Zheng, N., Niu, Y., Dong, X., Shi, Y., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.01.018 · Cited by 10

Adiponectin as a potential mediator of the pro-cognitive effects of physical exercise on Alzheimer’s disease

Guo, H., Ou, H., Yu, J., Rosa, J. M., Formolo, D. A., Cheng, T., Yau, S., & Tsang, H. W. H. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-00943 · Cited by 11

From diabetes to renal aging: the therapeutic potential of adiponectin

Karamian, M., Moossavi, M., & Hemmati, M. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00790-4 · Cited by 9

Extracellular Superoxide Dismutase Attenuates Hepatic Oxidative Stress in Nonalcoholic Fatty Liver Disease through the Adenosine Monophosphate-Activated Protein Kinase Activation

Nam, H., Lim, J., Kim, T., Kim, E. S., Oum, S.-J., Bae, S. H., & Park, C. (2023) · Antioxidants · doi:10.3390/antiox12122040 · Cited by 9

Adiponectin as a therapeutic target for diabetic foot ulcer

Abdalla, M. M. I., Mohanraj, J., & Somanath, S. D. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i6.758 · Cited by 10

PPAR-α Insufficiency Enhances Doxorubicin-Induced Nephropathy in PPAR-α Knockout Mice and a Murine Podocyte Cell Line

Matsuta, K., Kamiyama, K., Imamoto, T., Takeda, I., Masunaga, S., Kobayashi, M., Takahashi, N., Kasuno, K., Hara, M., Iwano, M., et al. (2024) · Cells · doi:10.3390/cells13171446 · Cited by 9

Adiponectin is not associated with renal function decline in community-dwelling elderly adults

Kobayashi, H. H., Otsuka, H., Yanai, M., Haketa, A., Hara, M., Hishiki, M., Abe, M., & Soma, M. (2018) · Medicine · doi:10.1097/md.0000000000010847 · Cited by 9

Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice

Tarkhnishvili, A., Koentges, C., Pfeil, K., Gollmer, J., Byrne, N. J., Vosko, I., Lueg, J. C., Vogelbacher, L., Birkle, S., Tang, S., et al. (2022) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2022.11.2.161 · Cited by 9

The role of vasoactive peptides in skin homeostasis—focus on adiponectin and the kallikrein-kinin system

Silva, I. M. S., Steckelings, U. M., & Assersen, K. B. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00269.2022 · Cited by 7

AdipoRs- a potential therapeutic target for fibrotic disorders

Ma, L., Li, X., Bai, Z., Lin, X., & Lin, K. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1559823 · Cited by 9

Effects of the Novel LaPLa-Enriched Medium- and Long-Chain Triacylglycerols on Body Weight, Glycolipid Metabolism, and Gut Microbiota Composition in High Fat Diet-Fed C57BL/6J Mice

Shi, J., Wang, Q., Li, C., Yang, M., Hussain, M., Zhang, J., Feng, F., & Zhong, H. (2023) · Molecules · doi:10.3390/molecules28020722 · Cited by 8

ADIPOR1 regulates genes involved in milk fat metabolism in goat mammary epithelial cells

Zhao, W., Adjei, M., Wang, H., Yangliu, Y., Zhu, J., & Wu, H. (2021) · Research in Veterinary Science · doi:10.1016/j.rvsc.2021.04.001 · Cited by 7

Low molecular weight heparin promotes the PPAR pathway by protecting the glycocalyx of cells to delay the progression of diabetic nephropathy

Zhang, B., Bu, C., Wang, Q., Chen, Q., Shi, D., Qiu, H., Wang, Z., Liu, J., Wang, Z., Zhang, Q., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107493 · Cited by 7

Adiponectin receptor agonist AdipoRon alleviates memory impairment in the hippocampus of septic mice

Bai, G., Ling, J., Lu, J. F., Fang, M., & Yu, S. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115174 · Cited by 7

Adipose-Renal Axis in Diabetic Nephropathy

Yang, M., Song, P., Zhao, L., & Wang, X. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220806115518 · Cited by 7

Association and biomarker potential of elevated serum adiponectin with nephropathy among type 1 and type 2 diabetics: A meta-analysis

Pabalan, N., Tiongco, R. E., Pandac, J. K., Paragas, N. A., Lasta, S. L., Gallego, N., Jarjanazi, H., & Pineda-Cortel, M. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208905 · Cited by 7

Challenging Sarcopenia: Exploring AdipoRon in Aging Skeletal Muscle as a Healthspan-Extending Shield

Selvais, C. M., de Carrizosa, M. A. D., Versele, R., Dubuisson, N., Noël, L., Brichard, S. M., & Abou‐Samra, M. (2024) · Antioxidants · doi:10.3390/antiox13091073 · Cited by 7

FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice

Zhou, J., Wang, S., Lou, J., Pan, B., Zhao, M., Li, Q., Zhou, J., Du, Y., Ding, S., Yu, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65978-4 · Cited by 8

AdipoRon Alleviates Liver Injury by Protecting Hepatocytes from Mitochondrial Damage Caused by Ionizing Radiation

Liu, Y., Xu, Y., Ji, H., Gao, F., Ge, R., Zhou, D., Fu, H., Liu, X., & Ma, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011277 · Cited by 6

Association of diabetic nephropathy with lipid metabolism: a Mendelian randomization study

Xie, P., Xie, W., Wang, Z., Guo, Z., Tang, R., Yang, H., Yu, W., Zhou, L., Huang, Y., Zhao, L., et al. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01641-8 · Cited by 6

AdipoRon Engages Microglia to Antinociception through the AdipoR1/AMPK Pathway in SNI Mice

Fang, Q., Li, J., Wang, Y., Liu, X., Shi, Y., Chen, J., Zhan, H., Zeng, Y., & Wu, W. (2023) · Mediators of Inflammation · doi:10.1155/2023/7661791 · Cited by 7

NO enhances the adaptability to high-salt environments by regulating osmotic balance, antioxidant defense, and ion homeostasis in eelgrass based on transcriptome and metabolome analysis

Wang, X., Wang, T., Yu, P., Li, Y., & Lv, X. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1343154 · Cited by 6

High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell

Qin, J., Chen, Z., Ye, M., Liang, L., & Ding, X. (2025) · Autoimmunity · doi:10.1080/08916934.2025.2576881 · Cited by 5

Adiponectin Signaling Ameliorates Cognitive Dysfunction in Type 2 Diabetic Mice by Activating the Hippocampal AdipoR2-PPARα/CREB Pathway

Gong, H., Liu, Y., Liu, X., Niu, B., Kong, J., Wang, B., Lin, X., Lin, L., & Bi, Y. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05383-6 · Cited by 5

The interactions between autophagy and immune in the liver-adipose-ovary circuit of polycystic ovary syndrome

Nie, G., Liu, M., Yang, L., Li, C., Qu, C., Wang, J., Mei, J., Wang, Y., Han, L., Zhang, X., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1733950 · Cited by 5

Tangeretin Enhances Muscle Endurance and Aerobic Metabolism in Mice via Targeting AdipoR1 to Increase Oxidative Myofibers

Li, J., Li, J., Ullah, A., Shi, X., Zhang, X., Cui, Z., Lyu, Q., & Kou, G. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09386 · Cited by 5

UHRF1 promotes calcium oxalate-induced renal fibrosis by renal lipid deposition via bridging AMPK dephosphorylation

Sun, Y., Li, B., Song, B., Xia, Y., Ye, Z., Lin, F., Zhou, X., Li, W., Rao, T., & Fan, C. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-09991-9 · Cited by 5

Hyperlipidemic plasma molecules bind and inhibit adiponectin activity

Zhang, Y., Fan, S., Wang, W., Lau, W. B., Dai, J., Zhang, H., Wang, X., Liu, X., & Li, R. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13746 · Cited by 5

Crocin protects against endoplasmic reticulum stress-related tubular injury in diabetic nephropathy via the activation of the PI3K/AKT/Nrf2 pathway.

Wang, G., Deng, J., & Zhou, H. (2024) · PubMed Central · doi:10.22038/ijbms.2023.73385.15942 · Cited by 5

Efficacy of ADIPOR1 and ADIPOR2 peptide‐agonist AdipoRon in preventing contracture in a rabbit model of arthrofibrosis

Salmons, H. I., Carstens, M. F., Limberg, A. K., Bettencourt, J. W., Payne, A. N., Karczewski, D. C., Ryan, Z., Morrey, M. E., Sánchez‐Sotelo, J., Berry, D. J., et al. (2024) · Journal of Orthopaedic Research® · doi:10.1002/jor.25853 · Cited by 5

A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

Thomas, H. Y., & Versypt, A. N. F. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1481768 · Cited by 6

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy

Chen, S., Wang, X., Sun, D., Zhang, S., Liu, P., Xu, X., Wei, F., & Liu, Q. (2025) · Current Eye Research · doi:10.1080/02713683.2025.2516802 · Cited by 5

Captopril and Spironolactone can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting ABCA1 and microRNA-33

Ghaffari, T., Moradi, N., Chamani, E., Ebadi, Z., Fadaei, R., Alizadeh‐Fanalou, S., Yarahmadi, S., & Fallah, S. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220401143249 · Cited by 5

The Role of Human Adiponectin Receptor 1 in 2-Ethylhexyl Diphenyl Phosphate Induced Lipid Metabolic Disruption

Feng, J., Ma, X., Liu, Y., Shi, X., Jin, L., Le, Y., Zhang, Q., & Wang, C. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c07051 · Cited by 4

Analysis of high glucose injury using human induced pluripotent stem cell-derived kidney organoids

Qian, Z., Yang, D., Li, Y., Dong, R., Da, J., Chen, Y., & Zha, Y. (2026) · BMC Nephrology · doi:10.1186/s12882-025-04566-6 · Cited by 4

Contentious role of ‘Good Adiponectin’ in pulmonary and cardiovascular diseases: Is adiponectin directed therapy a boon or a bane?

Pathak, M. P., Das, A., Patowary, P., & Chattopadhyay, P. (2020) · Biochimie · doi:10.1016/j.biochi.2020.05.008 · Cited by 4

Adiponectin affects estimated glomerular filtration rate: A two‐sample bidirectional Mendelian randomization study

Bai, Y., Chen, Z., Wen, Z., Long, X., Mo, Z., & Xu, J. (2021) · Nephrology · doi:10.1111/nep.13836 · Cited by 4

AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice

Wu, X., Zhu, D., Shi, L., Tu, Q., Yu, Y., & Chen, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13975 · Cited by 4

DsbA-L: A Promising Therapeutic Target for Metabolic Diseases

Yang, M., Luo, S., Yang, J., Chen, W., He, L., Liu, D., Wang, X., Xiao, L., & Sun, L. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673252630231018044159 · Cited by 4

AdipoRon reduces cisplatin-induced ototoxicity in hair cells:possible relation to the regulation of mitochondrial biogenesis

Nong, H., Song, X., Li, Y., Xu, Y., Wang, F., Wang, Y., Zhang, J., Chen, C., & Li, J. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137577 · Cited by 5

Effects of metformin on knee joint capsule fibrosis in a diabetic mouse model

Naito, T., Yamanaka, Y., Tokuda, K., Sato, N., Tajima, T., Tsukamoto, M., Suzuki, H., Kawasaki, M., Nakamura, E., & Sakai, A. (2024) · Bone and Joint Research · doi:10.1302/2046-3758.137.bjr-2023-0384.r1 · Cited by 4

Striking Cardioprotective Effects of an Adiponectin Receptor Agonist in an Aged Mouse Model of Duchenne Muscular Dystrophy

Abou‐Samra, M., Dubuisson, N., Marino, A., Selvais, C. M., Versele, R., de Carrizosa, M. A. D., Noël, L., Beauloye, C., Brichard, S. M., & Horman, S. (2024) · Antioxidants · doi:10.3390/antiox13121551 · Cited by 4

Integrin Trafficking, Fibronectin Architecture, and Glomerular Injury upon Adiponectin Receptor 1 Depletion

Lindfors, S., Schmotz, C., Lewandowski, D., Hau, A., Saikko, L., Lehtonen, E., Majaniemi, V., Karhe, M., Naams, J.-B., Nísen, H., et al. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000611 · Cited by 4

Association of Serum Unsaturated Fatty Acid Patterns with the Risk of Diabetic Nephropathy

Shuang, X., Li, X., Hou, Q., Xu, N., Lu, Q., Wang, S., & Dai, C. (2024) · Kidney Diseases · doi:10.1159/000536532 · Cited by 3

Acid ceramidase as a novel target for adiponectin receptor agonist to abrogate podocyte NLRP3 inflammasome activation and glomerular inflammation during obesity

Li, G., Huang, D., Kidd, J. M., Zou, Y., Wu, X., Zhang, Y., Gehr, T. W. B., Li, N., & Li, P. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103757 · Cited by 4

Morus alba L. (Sangzhi) alkaloids alleviate diabetic nephropathy by suppressing endoplasmic reticulum stress and modulating AMPK-associated phosphatidylethanolamine content

Zhang, S., Wen, Z., Xu, X., Zhou, Y., Chen, Y., Zhang, Y., Kan, Z., Wang, J., Wu, B., Chen, C., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157836 · Cited by 3

Electroacupuncture in the treatment of non-alcoholic fatty liver disease: mechanistic insights and therapeutic potential

Wang, Y., & Zhang, L. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1783519 · Cited by 3

Identification of AdipoRon analogues as novel activators of AMPK for the treatment of type 2 diabetes

Lin, C., Sun, G., & Li, Y. (2024) · RSC Medicinal Chemistry · doi:10.1039/d3md00727h · Cited by 3

FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle

Zhang, Y., Wang, F., Zhang, C., Yao, F., Zhang, B., Zhang, Y., & Sun, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1500458 · Cited by 3

The Pathological Mechanisms of Obesity-Related Glomerulopathy: A review article

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Yang, M., Liu, Y., Luo, S., Xiao, Y., Zhao, C., & Sun, L. (2023) · Diabetic Nephropathy · doi:10.2478/dine-2023-0001 · Cited by 2

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Wan, Y., Zhang, L., Wang, L., Zhang, Y., & Gao, F. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110371 · Cited by 2

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Adiponectin receptor agonist, AdipoRon, reduces the growth of prostate cancer cells and patient-derived organoids

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Relationship between septic acute kidney injury and adiponectin: A retrospective study in patients undergoing continuous plasma exchange with dialysis

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Chen, C., Ji, Y., Liu, H., Pang, L., Chen, J., Chen, H., Yao, Y., Ye, J., Wang, S., Liu, S., et al. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05206-1 · Cited by 1

Potential targets of protecting podocyte in glomerular aging and injury

Zhong, Z. (2025) · Discover Medicine · doi:10.1007/s44337-025-00384-9 · Cited by 1

Isolating and Culturing Mouse Podocyte Cells to Study Diabetic Nephropathy

Vasilopoulou, E. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9841-8_5 · Cited by 1

Linking adiponectin expression and kidney dysfunction among Indian patients with and without diabetic nephropathy

Ganesh, V. (2022) · Bioinformation · doi:10.6026/97320630018876 · Cited by 1

Antidiabetic features of AdipoAI, a novel AdipoR agonist.Preprint

Tu, Q., Ahuja, A., Zboinski, E., das, S., Zhu, Z. X., Ma, Q., Xie, Y., & Chen, J. (2023) · doi:10.22541/au.168863049.91214545/v1 · Cited by 1

The role of adiponectin and its receptor in patients with idiopathic membranous nephropathy complicated with hyperuricemia

Liu, T., Xia, M., Zhang, Y., Wang, Y., & Zhou, Y. (2021) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh200519031l

Adiponectin Ameliorates Hypertrophic Scar by Inhibiting YAP Transcription Through SIRT1-Mediated Deacetylation of C/EBPβ and Histone H3Preprint

Zhang, J., Li, Y., Liu, J., Han, F., Shi, J., Wu, G., Wang, K., Shen, K., Zhao, M., Gao, X., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4077250

AdipoRon engages microglia to analgesia through the AdipoR1-AMPK pathway in SNI micePreprint

Fang, Q., Wang, Y., Liu, X., Shi, Y., Chen, J., Zhan, H., Zeng, Y., & Wu, W. (2022) · Research Square · doi:10.21203/rs.3.rs-1683288/v1

AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress

Xiong, S., Han, Y., Gao, P., Zhao, H., Jiang, N., & Sun, L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6104375 · Cited by 13

Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy

Choi, S. R., Lim, J. H., Kim, M. Y., Kim, E. N., Kim, Y., Choi, B. S., Kim, Y.-S., Kim, H. W., Lim, K., Kim, M.-J., et al. (2018) · Metabolism · doi:10.1016/j.metabol.2018.02.004 · Cited by 150

Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy

Park, H. S., Lim, J. H., Kim, M. Y., Kim, Y., Hong, Y. A., Choi, S. R., Chung, S., Kim, H. W., Choi, B. S., Kim, Y., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0922-9 · Cited by 109

Intraperitoneal administration of the globular adiponectin gene ameliorates diabetic nephropathy in Wistar rats

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