CoChat
Sign Up
Cited by 116Electrolyte and hormonal disordersIon Transport and Channel RegulationRenin-Angiotensin System Studies

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Vasopressin increases glomerular filtration rate in conscious rats through its antidiuretic action.

Bouby, N, Ahloulay, M, Nsegbe, E, Déchaux, M, Schmitt, F, Bankir, L·1996·Journal of the American Society of Nephrology
DOI 10.1681/asn.v76842
Open this paper in CoChat — free account

Abstract

To evaluate the possible influence of chronic alterations in urine concentrating activity (CA) on renal hemodynamics, adult male Sprague-Dawley rats were submitted for 7 days to one of three different levels of CA. CA was either reduced by increasing water intake (mixing the food with a gel bringing 1.6 mL water per g food) (Low-CA), or increased by chronic intraperitoneal infusion of 1-desamino 8-D-arginine vasopressin (200 ng/day) (High-CA). Low-CA, High-CA, and control rats were housed in metabolic cages, ate the same quantity of dry food (the amount provided being slightly lower than the spontaneous intake), and had free access to drinking water. The only difference between groups thus concerned the water intake-vasopressin axis. Radiolabeled (14C)inulin was infused chronically by osmotic minipumps. Urine was collected during Days 5, 6, and 7, and blood samples were taken for determination of plasma composition (P), absolute and fractional (FE) urinary excretion, and clearance (C) of inulin, creatinine, urea, and main electrolytes. This protocol produced mean 24-h urine osmolality (Uosm) ranging from 500 to 3500 mosmol/kg H2O without inducing any disturbance in body fluids or plasma osmolality (Posm). Results show that GFR (Cinulin) was markedly and positively correlated with Uosm (r = 0.798, P < 0.001) and free water reabsorption (r = 0.819, P < 0.001). For Uosm = 2500 mosm/kg H2O, GFR was 47% higher than for Uosm = 500 mosm/kg H2O. Ccreat underestimated GFR in High-CA and overestimated it in Low-CA. FEurea was inversely related to Uosm, as expected from the increased reabsorption known to occur at low urine flows. It is tentatively proposed that the intrarenal recycling of urea, triggered by vasopressin and essential to the urinary concentrating mechanism, might influence GFR indirectly by modifying the composition of the tubular fluid at the macula densa and thus the intensity of the tubuloglomerular feedback control of GFR. Even if this mechanism remains to be confirmed, this study unequivocally demonstrates, in normal conscious rats, that the level of urinary concentrating activity has a major influence on basal GFR.

Overview

Integrity signals

Registry

Crossref · 10.1681/asn.v76842

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 7 references

Cited by

Sorted by citations

Items 101–115 of 115

Related

See all

Metadata

Authors
Bouby, N., Ahloulay, M., Nsegbe, E., Déchaux, M., Schmitt, F., & Bankir, L.
Affiliations
Hôpital Necker-Enfants Malades (FR)
ORCID
Venue
Journal of the American Society of Nephrology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1996-06
Volume
7
Issue
6
Pages
842-851
ISSN
1046-6673 (ISSN-L)
DOI
10.1681/asn.v76842
OpenAlex
W1946571802
Cited by
116
References
7
Citations by year
2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 11 · 2012: 2
FWCI
2.42
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Society of Nephrology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
vasopressin, glomerular filtration rate, free water reabsorption, tubuloglomerular feedback, urea recycling, renal hemodynamics, inulin clearance, macula densa, water intake, urea reabsorption, plasma osmolality
MeSH terms
Animals, Creatinine, Deamino Arginine Vasopressin, Diuresis, Drinking, Glomerular Filtration Rate, Kidney Concentrating Ability, Male, Osmolar Concentration, Urine, Vasopressins, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review